Shadow of a Pandemic: Persistence of Prenatal SARS-CoV-2 Antibodies in Newborn Blood Spots DOI Creative Commons
Stanley Sciortino, Stephen M. Graham, Toki Fillman

et al.

International Journal of Neonatal Screening, Journal Year: 2023, Volume and Issue: 9(3), P. 43 - 43

Published: Aug. 2, 2023

To investigate COVID-19 surveillance among pregnant women, the California Genetic Disease Screening Program conducted a screening performance and seroprevalence evaluation of maternal SARS-CoV-2 antibodies detected in banked newborn dried blood spots (DBS). We obtained seropositive results for 2890 DBS from cohorts 2020 2021 using Enable Bioscience's Antibody Detection by Agglutination-PCR (ADAP) assay antibodies. infer infection, we linked 312 women with known laboratory-confirmed episode their newborn's SARS-CoV02 antibody result. Among newborns, 453 (15.7%) DBS. Monthly snapshot statewide neonates was 12.2% (95% CI 10.3-14.1%, n =1156) December 33.3% 29.1-37.4%, = 26) March 2021. The longest time recorded infection to neonatal result 11.7 months mothers who had an available PCR test Approximately 94% (153/163) were when occurred earlier than 19 days before birth. estimated relative sensitivity identify prevalent 85.1%, specificity 98.5% PPV 99.2% (n 312); lowest during surge many infections within Fifty pre-pandemic specimens (100% seronegative) 23 twin-pair concordant) support intrinsic ADAP approaching 100%. Maternal is limited lag prior delivery, especially pandemic surges.

Language: Английский

Risk factors and outcomes of critically ill pregnant COVID-19 patients: Experience from the first and second waves of the pandemic DOI Creative Commons
Dita Aditianingsih,

Noor Hafidz,

Aino Nindya Auerkari

et al.

˜The œJournal of Critical Care Medicine, Journal Year: 2025, Volume and Issue: 11(1), P. 54 - 63

Published: Jan. 1, 2025

Abstract Introduction Understanding the association between risk factors and clinical outcomes of COVID-19 can lead to identifying suitable management strategies for reducing mortality rate among maternal patients in ICU. Aim Study This study aims investigate associated with pregnant postpartum women diagnosed admitted intensive care unit (ICU) May 2020 September 2021. Materials Methods retrospective cohort was conducted at Universitas Indonesia Hospital. Secondary data collected from medical records include all confirmed hospital during research period. Results The included 113 found that admission ICU, age, gestational age significantly influenced outcomes, a 42.11% ICU-admitted patients. Pre-existing comorbidities such as type-2 diabetes mellitus, congestive heart failure, coronary artery disease were ICU admission. Having least one comorbidity increase by six-fold. Conclusions emphasizes importance monitoring evaluating fetal complications infection, highlighting need multidisciplinary involving intensivists, obstetricians, anesthesiologists, infectious specialists. findings underscore significance baseline health status treatment planning potential evidence-based interventions improve pregnancy preservation. Further is warranted validate these results enhance understanding underlying pathophysiology.

Language: Английский

Citations

0
Clinical characteristics of pregnant women with COVID-19 and infection outcomes in one of the largest cities in the Brazilian Amazon DOI Creative Commons
Ana Paula Figueiredo de Montalvão França,

Jenephy Thalita Rosa Paixão,

Ricardo Roberto de Souza Fonseca

et al.

BMC Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(1)

Published: Oct. 18, 2024

Pregnancy can be a risk factor for the development of more severe COVID-19 with possible increase in complications during pregnancy/birth and adverse neonatal outcomes. This study aimed to describe analyze clinical epidemiological aspects SARS-CoV-2 infection women perinatal period attended city Belém, northern region Brazil.

Language: Английский

Citations

2
Efficacy and safety of therapies for COVID-19 in pregnancy: a systematic review and meta-analysis DOI Creative Commons
Francesco Di Gennaro, Giacomo Guido, Luisa Frallonardo

et al.

BMC Infectious Diseases, Journal Year: 2023, Volume and Issue: 23(1)

Published: Nov. 9, 2023

Abstract Background Clinical evidence suggests that pregnant women are more vulnerable to COVID-19, since they at increased risk for disease progression and obstetric complications, such as premature labor, miscarriage, preeclampsia, cesarean delivery, fetal growth restriction perinatal death. Despite this evidence, often excluded from clinical trials, resulting in limited knowledge on COVID-19 management. The aim of systematic review meta-analysis is provide better the efficacy safety available treatment women. Methods Four authors searched major electronic databases inception until 1 st November-2022 controlled trials/observational studies, investigating outcomes after administration anti-SARS-CoV-2 treatments affected by COVID-19. analyses investigated cumulative incidence delivery maternal women, comparing those taking active medication vs standard care. Risk ratios (RRs) with 95% confidence intervals were calculated. Statistical significance was assessed using random effects model inverse-variance method. This conducted accordance updated 2020 Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) guidelines. protocol has been registered Prospero (number registration: CRD42023397445). Results From initially 937 non duplicate records, we full texts 40 articles, finally including ten studies. In six 1627 patients, use casirivimab/imdevimab (CAS/IMD), remdesivir, IFN-alpha 2b significantly decreased need section ((RR = 0.665; 95%CI: 0.491–0.899; p 0.008; I 2 19.5%;) (Table 1, (Fig. 1). Treatments did not decrease preterm admission neonatal ICU, or stillbirth/perinatal loss ( -values > 0.50 all these outcomes) prevent towards severe degrees (k 8; 2,374 women; RR 0.778; 0.550–1.099; 0.15; 0%). Moreover, medications during pregnancy modify death two studies 2). Conclusions To our analysis, CAS/IMD, IFN alpha reduced number sections but demonstrated no effect other related outcomes. inability evaluate influence viral load illness development attributed lack data. review, side reported. Though, it essential medical community focus trials less episodic case reports series, standardization

Language: Английский

Citations

4
Mendelian Randomization Study: Investigating the Causal Impact of Covid-19 on Adverse Pregnancy Outcomes DOI Creative Commons

Ruisi Tang,

Weijie Guo,

Ying Hu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 29, 2024

Abstract Background Due to limitations in observational studies, the link between COVID-19 and adverse pregnancy outcomes (APOs) remains inconclusive. This study uses two-sample Mendelian randomization (MR) analyses assess COVID-19's causal effects on APO traits. Methods We applied inverse variance weighting (IVW), MR-Egger, weighted median, mode, simple mode thoroughly evaluate of infection, hospitalization, severity eight Results Our findings indicate that infection is associated with an increased risk spontaneous miscarriages (OR: 0.95, 95%CI (0.99, 0.91); p = 0.014) preterm labor delivery 1.30, (1.63, 1.04); 0.019), a decreased eclampsia 0.35, (0.94, 0.12); 0.033).

Language: Английский

Citations

0
Severity and prognosis of COVID-19 complicated by autoimmune pulmonary alveolar proteinosis DOI
Toru Arai, Yoshikazu Inoue,

Keiichi Akasaka

et al.

Respiratory Investigation, Journal Year: 2024, Volume and Issue: 63(1), P. 20 - 26

Published: Nov. 29, 2024

Language: Английский

Citations

0
Shadow of a Pandemic: Persistence of Prenatal SARS-CoV-2 Antibodies in Newborn Blood Spots DOI Creative Commons
Stanley Sciortino, Stephen M. Graham, Toki Fillman

et al.

International Journal of Neonatal Screening, Journal Year: 2023, Volume and Issue: 9(3), P. 43 - 43

Published: Aug. 2, 2023

To investigate COVID-19 surveillance among pregnant women, the California Genetic Disease Screening Program conducted a screening performance and seroprevalence evaluation of maternal SARS-CoV-2 antibodies detected in banked newborn dried blood spots (DBS). We obtained seropositive results for 2890 DBS from cohorts 2020 2021 using Enable Bioscience's Antibody Detection by Agglutination-PCR (ADAP) assay antibodies. infer infection, we linked 312 women with known laboratory-confirmed episode their newborn's SARS-CoV02 antibody result. Among newborns, 453 (15.7%) DBS. Monthly snapshot statewide neonates was 12.2% (95% CI 10.3-14.1%, n =1156) December 33.3% 29.1-37.4%, = 26) March 2021. The longest time recorded infection to neonatal result 11.7 months mothers who had an available PCR test Approximately 94% (153/163) were when occurred earlier than 19 days before birth. estimated relative sensitivity identify prevalent 85.1%, specificity 98.5% PPV 99.2% (n 312); lowest during surge many infections within Fifty pre-pandemic specimens (100% seronegative) 23 twin-pair concordant) support intrinsic ADAP approaching 100%. Maternal is limited lag prior delivery, especially pandemic surges.

Language: Английский

Citations

0