Ozone in Dentistry: An Updated Overview of Current Applications and Future Perspectives
Current Oral Health Reports,
Journal Year:
2025,
Volume and Issue:
12(1)
Published: Jan. 14, 2025
Abstract
Purpose
of
Review
Oxygen-ozone
therapy
(OOT)
is
increasingly
applied
due
to
its
multiple
therapeutic
effects,
but
it
still
controversial
in
the
medical
community.
This
review
provides
a
comprehensive
overview
recent
clinical
literature
on
OOT
dentistry,
exploring
efficacy
and
current
issues.
Recent
Findings
has
wide
range
applications
including
caries
management,
endodontics,
periodontics,
oral
surgery.
Overall,
results
are
promising
with
very
limited
adverse
effects.
The
formulations
used
include
gaseous
ozone,
ozonized
water,
gel,
ozonization
various
products.
A
large
methodologic
heterogeneity
currently
prevents
definitive
conclusions
meaningful
comparisons
between
different
protocols.
Summary
Although
not
conclusive,
evidence
suggests
that
may
offer
some
advantages
as
an
adjunctive
or
alternative
treatment
option
certain
conditions.
Future
research
should
aim
standardize
reporting
methodology
protocols
order
make
guide
selection
best
for
specific
endpoints.
Language: Английский
Effect of ozone oil and non-surgical periodontal treatment in patients with type 2 diabetes. In-vivo and in-vitro studies with fibroblasts and Candida albicans
Journal of Applied Oral Science,
Journal Year:
2025,
Volume and Issue:
33
Published: Jan. 1, 2025
Abstract
Aim
To
evaluate
the
clinical
effectiveness
of
ozonated
sunflower
oil
(Oz)
as
an
adjunctive
non-surgical
periodontal
therapy
in
patients
with
type
2
diabetes
mellitus
(DM2),
on
fibroblast
cell
viability
and
migration
Oz
a
Candida
albicans
(C.
albicans)
culture.
Methodology
In
total,
32
sites
16
DM2
moderate
to
advanced
disease
pocket
depths
≥5mm
were
selected.
The
treatments
divided
into
two
groups:
control,
saline
solution
(SS)
scaling
root
planing
(SRP+SS),
test,
SRP
(SRP+Oz).
Hematological
[fasting
glucose
level
(FGL)
hemoglobin
A1c
(HbA1c)]
microbiological
samples
collected
from
participants
at
baseline
three
months
after
treatment
analyzed
by
PCR.
C.
was
previously
tested
agar
diffusion
test.
effect
migration.
Results
groups
showed
no
statistically
significant
differences
(paired
t-test-p>0.05)
regarding
hematological
parameters,
FGL
(median
-
171.41,
3
164mg/dL),
HbA1c
(baseline
8%,
7.5%)
(Kruskal-Wallis
One-Way
Nonparametric-p>0.05)
therapy.
statistical
for
parameters
between
t-test-p<0.05).
PCR
analysis
reduction
percentage
SRP+Oz
group
(McNemar’s
test-p=0.002).
Cell
lower
high
Dulbecco’s
modified
Eagle’s
medium
(4500
mg/L)
than
low
(1000
(RM-ANOVA-p<0.0001).
wound
healing
test
reduced
(one-way
ANOVA
Dunnett’s
post-test-p<0.01).
antifungal
inhibition
test-p=0.0001).
Conclusions
effectively
in-vitro
in-vivo
but
improvements
compared
control.
fibroblasts
improvements.
Language: Английский
The histopathologic evaluation of local effects of ozone therapy on the healing of experimental calvarial defects of rats
BMC Oral Health,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Jan. 22, 2025
This
study
evaluates
the
effects
of
ozone
on
hard
and
soft
tissue
healing
when
a
free
flap
is
used
to
close
wound
areas
lacking
primary
closure
over
autogenous
grafted
sites.
In
our
study,
24
male
Wistar
rats
were
divided
into
four
groups:
two
control
groups
ozone-treated
groups.
All
underwent
same
surgical
procedure.
After
surgery,
received
no
additional
treatment,
while
topical
application.
Ozone
was
applied
for
2
min,
three
times
per
week,
with
one-day
intervals,
duration
weeks
post-surgery.
Sacrifice
performed
14th
day
one
group,
28th
remaining
samples
then
examined
histopathologically.
Clinical
trial
number:
not
applicable.
Histopathological
evaluations
statistical
analyses
indicated
that
bone
significantly
better
in
group
compared
(p
=
0.049).
For
healing,
although
there
statistically
significant
difference
between
groups,
proportional
values
showed
recovery
controls.
The
present
concludes
has
positive
effect
new
formation
early
stages;
however,
it
healing.
We
believe
further
comprehensive
studies
would
be
beneficial
confirm
these
findings.
Language: Английский
The Impact of Ozone on Periodontal Cell Line Viability and Function
Nada Tawfig Hashim,
No information about this author
Rasha Babiker,
No information about this author
Shahistha Parveen Dasnadi
No information about this author
et al.
Current Issues in Molecular Biology,
Journal Year:
2025,
Volume and Issue:
47(2), P. 72 - 72
Published: Jan. 23, 2025
Periodontal
diseases,
including
gingivitis
and
periodontitis,
are
chronic
inflammatory
conditions
of
the
teeth’
supporting
structures
that
can
lead
to
progressive
tissue
destruction
loss
if
left
untreated.
Basic
treatments
like
scaling
root
planing,
alone
or
combined
with
antimicrobial
agents,
standard
care.
However,
increasing
prevalence
antibiotic
resistance
need
for
new
ideas
in
therapy,
adjunctive
ozone
therapy
have
gained
attention.
Ozone
(O3),
a
triatomic
oxygen
molecule,
is
used
because
its
strong
antimicrobial,
anti-inflammatory,
regenerative
activity
and,
hence,
as
potential
tool
periodontal
therapy.
This
review
use
disease
breaks
down
multifaceted
mechanism
which
includes
selective
action
against
biofilm-associated
pathogens,
immunomodulatory
effects
on
host
cells,
stimulation
repair.
O3
disrupts
microbial
biofilms,
enhances
immune
cell
function,
promotes
healing
by
activating
Nuclear
Factor
Erythroid
2-Related
2
(Nrf2)
Mitogen-Activated
Protein
Kinase
(MAPK)
signaling
pathways
regulate
oxidative
stress,
inflammation,
apoptosis.
Additional
findings
include
ability
upregulate
growth
factors
extracellular
matrix
proteins,
significant
regeneration.
also
discusses
application
lines,
emphasizing
impact
viability,
proliferation,
differentiation.
Advances
techniques,
properties
O3,
demonstrated
clinical
benefits.
Challenges,
standardized
dosages,
effective
delivery
systems,
long-term
studies,
addressed
ensure
safe
integration.
dual
capabilities,
offers
an
innovative
approach
treatment.
Future
research
focusing
optimized
protocols
evidence-based
guidelines
essential
fully
realize
enhancing
health
improving
patient
outcomes.
Language: Английский
Low-Dose Ozone as a Eustress Inducer: Experimental Evidence of the Molecular Mechanisms Accounting for Its Therapeutic Action
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(23), P. 12657 - 12657
Published: Nov. 25, 2024
Ozone
(O
Language: Английский