Metabolic Brain Disease, Journal Year: 2024, Volume and Issue: 39(5), P. 783 - 801
Published: May 13, 2024
Language: Английский
Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(5), P. 2482 - 2495
Published: March 6, 2024
Abstract Saffron is a spice derived from the flower of Crocus sativus L., which has been used for centuries as coloring and flavoring agent, well source medicinal compounds. contains various bioactive constituents, such crocin, crocetin, safranal, picrocrocin, kaempferol, that have shown potential benefits human health. Among them, crocin most abundant characteristic constituent saffron, responsible its bright red color antioxidant properties. One promising applications saffron constituents in prevention treatment neurological disorders, depression, anxiety, Alzheimer's disease, Parkinson's other brain disorders. reported to exert neuroprotective effects through mechanisms, modulating neurotransmitters, enhancing neurogenesis, reducing neuroinflammation, regulating oxidative stress, activating Nrf2 signaling pathway, epigenetic factors. Several clinical preclinical studies demonstrated efficacy safety improving cognitive function, mood, outcomes. In this review, we summarize current evidence on therapeutic bench bedside. We also discuss challenges future directions development saffron‐based therapies
Language: Английский
Citations
13
Heliyon, Journal Year: 2024, Volume and Issue: 10(2), P. e24334 - e24334
Published: Jan. 1, 2024
Due to an increase in the number of older people recent years, neurodegenerative diseases as most important age-related neurological disorders are considered a great threat human health. The treatment strategies for these symptomatic and there is no known definitive treatment; however, recently, several studies have investigated effectiveness some herbs their components limiting progression disorders. In this study, we searched Medline (via PubMed), Scopus, Science Direct, Google Scholar databases. keywords used search were: saffron [title/abstract] or (saffron compound [title/abstract]) (neurological [title/abstract]), publication date range (2010-2023), language (English). After applying inclusion exclusion criteria, 30 articles remained. Of included six on by its were clinical trial phase, 24 preclinical phase. Saffron compounds can play role inhibiting neuroinflammation excitotoxic pathways, modulating autophagy apoptosis, attenuating oxidative damage, activating defensive antioxidant enzymes, resulting neuroprotection against diseases. Therefore, study aimed review effects
Language: Английский
Citations
8
Pesticide Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 200, P. 105807 - 105807
Published: Jan. 29, 2024
Language: Английский
Citations
8
Journal of Food Biochemistry, Journal Year: 2024, Volume and Issue: 2024, P. 1 - 19
Published: March 11, 2024
Saffron, indicated as “the red gold,” is an extraordinary spice with a unique aroma and organoleptic properties that largely diffused in food preparation well traditional medicine many countries of the world. In last years, several studies have considered this for CNS-based disorders showing its potential usefulness. review, we role saffron nutraceutical management most CNS diseases considering important oxidative stress on pathogenesis such diseases. fact, recent findings support crucial different suggesting antioxidants. Preclinical clinical evidence efficacy physiopathological pathways involved were discussed pharmacological activities beneficial effects pathological models or small trials. Due to low toxicity significant inflammation ability modulate mitochondrial function, extracts their constituents appear be promising active compounds area. Further investigations are progress assess safety preventive agents nutraceuticals adjuvant used combinations other therapeutic approaches. Saffron antioxidant activity can useful improving quality life patients suffering from conditions related CNS. summarized more standardized products valuable instrument well-being due multiple targets health brain tissues.
Language: Английский
Citations
6
Toxicon, Journal Year: 2024, Volume and Issue: 241, P. 107687 - 107687
Published: March 12, 2024
Language: Английский
Citations
6
Biocatalysis and Agricultural Biotechnology, Journal Year: 2024, Volume and Issue: 59, P. 103260 - 103260
Published: May 29, 2024
Language: Английский
Citations
5
Drugs and Drug Candidates, Journal Year: 2024, Volume and Issue: 3(3), P. 437 - 454
Published: June 21, 2024
Plants and plant extracts have long been acknowledged as valuable resources for the development of therapeutic formulations various diseases. Among them, numerous plants plant-derived products demonstrated cytotoxic and/or anti-tumor properties. Saffron, particularly due to its major compounds, namely crocin, crocetin, safranal, stands out a promising candidate in this regard. Our research undertakes literature review, reaffirming antioxidant, anti-inflammatory, and, notably, properties saffron constituents. Additionally, study examines relevant patent documents, highlighting innovative applications compounds cancer therapy. The review discusses progress purifying extracted from assesses their impact on trial outcomes, potential synergies between certain established molecules, limitations patents examined, concerning reported clinical evidence. Researchers who focus advances oncology will know our findings evolution landscape regarding using or main compounds. Moreover, investigators can draw inspiration leveraging traditional knowledge, Chinese medicine, clarify specific active molecules mechanisms action expedite translation these into clinically interventions, potentially enhancing therapy outcomes.
Language: Английский
Citations
5
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: Sept. 29, 2024
Language: Английский
Citations
5
Foods, Journal Year: 2023, Volume and Issue: 12(22), P. 4080 - 4080
Published: Nov. 10, 2023
The substitution of synthetic food dyes with natural colorants continues to be assiduously pursued. current list carotenoid consists plant-derived annatto (bixin and norbixin), paprika (capsanthin capsorubin), saffron (crocin), tomato gac fruit lycopene, marigold lutein, red palm oil (α- β-carotene), along microalgal Dunaliella β-carotene Haematococcus astaxanthin fungal Blakeslea trispora lycopene. Potential sources are being sought, especially in relation for which commercial plant lacking. Research efforts, manifested numerous reviews research papers published the last decade, have been directed green extraction, microencapsulation/nanoencapsulation, valorization processing by-products. Extraction is shifting from conventional extraction organic solvents supercritical CO2 different types assisted extraction. Initially intended stabilization highly degradable carotenoids, additional benefits encapsulation demonstrated, improvement solubility bioavailability. Instead searching new higher sources, enormous effort has utilization by-products vegetable industry, application biorefinery circular economy concepts. Amidst activities, however, gap between industrial implementation remains wide.
Language: Английский
Citations
11
Toxicon X, Journal Year: 2025, Volume and Issue: unknown, P. 100215 - 100215
Published: Jan. 1, 2025
Language: Английский
Citations
0