Multi-omics pan-cancer study of SPTBN2 and its value as a potential therapeutic target in pancreatic cancer DOI Creative Commons

Hongliang Chang,

Hong Chen, Taiheng Ma

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: April 29, 2024

Abstract SPTBN2 is a protein-coding gene that closely related to the development of malignant tumors. However, its prognostic value and biological function in pan-cancer, especially pancreatic cancer (PAAD), have not been reported. In present study, novel exploration potential mechanism PAAD was conducted using multi-omics background pan-cancer. Via various database analysis, up-regulated expression detected most tumor tissues examined. Overexpression kidney renal clear cell patients potentially affected overall survival, disease-specific progression-free interval. PAAD, can be used as an independent factor affecting prognosis. Mutations amplification were detected, with abnormal methylation survival outcome patients. Immunoassay results demonstrate biomarker for predicting therapeutic response may influence immunotherapy efficacy by regulating levels CD8 + T cells neutrophil infiltration. Results from enrichment analysis indicated regulate via immune pathways. Thus, target based on crucial role PAAD.

Language: Английский

Assessment of XCI skewing and demonstration of XCI escape region based on single-cell RNA sequencing: comparison between female Grave’s disease and control DOI Creative Commons
In‐Cheol Baek, Soo Yeun Sim, Byung‐Kyu Suh

et al.

BMC Molecular and Cell Biology, Journal Year: 2025, Volume and Issue: 26(1)

Published: Jan. 31, 2025

The reactivation and loss of mosaicism hypothesis due to X chromosome inactivation (XCI) skewing escape could influence gender differences in autoimmune diseases. XCI selectively inactivates one the two chromosomes females. To estimate occurrence escape, we conducted a normal female (NF) without history thyroid disease (AITD) patient with Grave's (GD) based on diagnosis. After single-cell RNA sequencing, heterozygous variants were converted transformed. was calculated using formula degree defined. NF/GD genes compared correction methods. Positions are within single cell as indicated by unique barcode. showed 45.8%/48.9% relatively random, 29.4%/27.0% skewing, 24.6%/23.7% severe 0.2%/0.4% extreme skewing. 24.8%/24.1% exhibited or higher. A total 13 significantly associated ratios cells. In total, 371/250 nucleotide positions only barcode (representing cell) identified for escape. 143/52 spanned 20/6 genes, 12/1 escapes. These results aid understanding immunogenetics various pathophysiologies.

Language: Английский

Citations

0
Identification and RT-qPCR Validation of Biomarkers Based on Butyrate Metabolism-Related Genes to Predict Recurrent Miscarriage DOI Creative Commons
Wei Wang, Haobo Chen, Qiaochu Zhou

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 6917 - 6934

Published: Oct. 1, 2024

To date, the cause of recurrent miscarriage (RM) in at least 50% patients remains unknown. However, no study has explored correlation between butyrate metabolism-related genes (BMRGs) and RM.

Language: Английский

Citations

2
Role of HDAC6-STAT3 in immunomodulatory pathways in Colorectal cancer cells DOI
Claudia Mardones,

Camila Navarrete-Muñoz,

M Armijo

et al.

Molecular Immunology, Journal Year: 2023, Volume and Issue: 164, P. 98 - 111

Published: Nov. 21, 2023

Language: Английский

Citations

4
Association of plasma microRNA-16-5p and abdominal aortic calcification in maintenance hemodialysis patients DOI Creative Commons

Qiaojing Liang,

Chen Fu, Yingjie Liu

et al.

Renal Failure, Journal Year: 2024, Volume and Issue: 46(2)

Published: July 25, 2024

Recent studies have shown that

Language: Английский

Citations

1
Competing Endogenous RNAs (ceRNAs) and Application of Their Regulatory Networks in Complex Traits and Diseases of Ruminants DOI Creative Commons
Farzad Ghafouri,

Vahid Dehghanian Reyhan,

Mostafa Sadeghi

et al.

Ruminants, Journal Year: 2024, Volume and Issue: 4(2), P. 165 - 181

Published: April 1, 2024

This manuscript summarizes information on the diverse range of RNA molecules and their role as competing endogenous RNAs (ceRNAs). Moreover, it provides an overview ceRNA regulatory networks applications in ruminant biology. Knowledge co-expression has increased with microarrays, RNA-seq, scRNA-seq characterizing molecular mediators across various biological scales, using sequences from numerous blood tissue samples. By synthesizing existing knowledge, this study interactions between coding non-coding through microRNA response elements (MREs), elucidating large-scale throughout transcriptome that influence expression activities ceRNAs. Identification important functions will revolutionize understanding biology, shifting mRNA-centric model to a complex network crosstalk. The offer more comprehensive arguably realistic perspective compared protein–protein interaction (PPI) weighted gene (WGCN). These can describe potential mechanisms related functional economically traits ruminants, plus contribute disease pathology research, by pathogenesis drug effects cancer models. Furthermore, they provide insights into farm animal e.g., reproductive goats sheep, regulation fat metabolism beef cattle, heat stress responses, lactation dairy fertility muscle characteristics buffalo, resistance high-salt water-deprivation conditions camels. In conclusion, associated should promote new identify candidate genes metabolic-signaling pathways ruminants.

Language: Английский

Citations

0
Multi-omics pan-cancer study of SPTBN2 and its value as a potential therapeutic target in pancreatic cancer DOI Creative Commons

Hongliang Chang,

Hong Chen, Taiheng Ma

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: April 29, 2024

Abstract SPTBN2 is a protein-coding gene that closely related to the development of malignant tumors. However, its prognostic value and biological function in pan-cancer, especially pancreatic cancer (PAAD), have not been reported. In present study, novel exploration potential mechanism PAAD was conducted using multi-omics background pan-cancer. Via various database analysis, up-regulated expression detected most tumor tissues examined. Overexpression kidney renal clear cell patients potentially affected overall survival, disease-specific progression-free interval. PAAD, can be used as an independent factor affecting prognosis. Mutations amplification were detected, with abnormal methylation survival outcome patients. Immunoassay results demonstrate biomarker for predicting therapeutic response may influence immunotherapy efficacy by regulating levels CD8 + T cells neutrophil infiltration. Results from enrichment analysis indicated regulate via immune pathways. Thus, target based on crucial role PAAD.

Language: Английский

Citations

0