Medial or Lateral, That Is the Question: A Retrospective Study to Compare Two Injection Techniques in the Treatment of Knee Osteoarthritis Pain with Hyaluronic Acid

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(4), P. 1141 - 1141

Published: Feb. 17, 2024

: Mild-to-moderate knee osteoarthritis (KOA) can be successfully treated using intra-articular hyaluronic acid (IA-HA). The medial infrapatellar (MIP) approach and lateral (LIP) are two of the most used techniques for performing IA-HA, but it is still not clear which one preferable.

Language: Английский

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Silk Fibroin-Platelet Rich Plasma Injectable Hydrogel with Controlled-Release of Growth Factors for Knee Osteoarthritis

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106625 - 106625

Published: Jan. 1, 2025

Language: Английский

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A meta-analysis and systematic review of the clinical efficacy and safety of platelet-rich plasma combined with hyaluronic acid (PRP + HA) versus PRP monotherapy for knee osteoarthritis (KOA)

Journal of Orthopaedic Surgery and Research, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 17, 2025

KOA, a chronic degenerative joint disease, is commonly treated with intra-articular HA and PRP, used alone or in combination. However, the efficacy safety of combination therapy (PRP + HA) remain unclear. The aim this systematic review meta-analysis to assess clinical effectiveness profile PRP versus monotherapy for KOA. A search was conducted using four electronic databases (PubMed, EMBASE, Scopus, Cochrane Library) select publications published peer-reviewed journals. mean difference (MD) risk ratio (RR) calculated, along their 95% confidence intervals. We assessed heterogeneity Q I2statistics appropriate p-value. analysis RevMan 5.4. GRADE system evidence assessment each outcome parameter. This 11 RCTs (n = 1023 KOA patients) revealed that has substantial than reducing OMAC total scores [MD -1.77 (95% CI -2.20 − 1.34); I2 10%, p < 0.001], VAS -4.27 -4.96 3.58); 13%, Lequesne index score -5.48 -6.56 4.40); 16%, while increasing IKDC -2.10 -3.70 0.50); 9%, 0.01], low adverse events [RR 0.41 0.35 0.48); 12%, 0.001]. reveals that, patients safe yields better outcomes pain relief functional improvement compared monotherapy.

Language: Английский

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Extracecellulr vesicles (EVs) microRNAs (miRNAs) derived from mesenchymal stem cells (MSCs) in osteoarthritis (OA); detailed role in pathogenesis and possible therapeutics

Heliyon, Journal Year: 2025, Volume and Issue: unknown, P. e42258 - e42258

Published: Jan. 1, 2025

Language: Английский

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SDF-1 alleviates osteoarthritis by resolving mitochondrial dysfunction through the activation of the Sirt3/PGC-1α signalling pathway

Arthritis Research & Therapy, Journal Year: 2025, Volume and Issue: 27(1)

Published: March 7, 2025

Osteoarthritis (OA) is the most common form of joint disease. Currently, OA treatment limited to controlling symptoms. Our previous study showed that stromal cell-derived factor 1 (SDF-1) delayed progression a certain extent. The aim this was explore specific mechanism SDF-1 in OA. chondrocytes and collagen-induced osteoarthritis (CIOA) mouse model were used as vitro vivo models, respectively. treat vivo. To treatment, we pretreated with Sirt 3 inhibitor assessed mitochondrial function then analysed related indicators cartilage anabolic metabolism. SOD2 PGC-1α levels significantly lower CIOA mice than normal chondrocytes, dysfunction occurred After treating exogenous SDF-1, abnormal biomarkers normalized. pretreatment or before exposure reversed these changes. can alleviate by resolving through activation Sirt3/PGC-1α signalling pathway, therefore, may be good candidate new for

Language: Английский

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The causal effect of cytokine cycling levels on osteoarthritis: a bidirectional Mendelian randomized study

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 11, 2024

Osteoarthritis (OA) is the most prevalent joint disease globally, serving as a primary cause of pain and disability. However, pathological processes underlying OA remain incompletely understood. Several studies have noted an association between cytokines OA, yet causal link them remains ambiguous. This study aims to identify potentially causally related using Mendelian randomization (MR) analysis, informing early clinical diagnosis treatment decisions.

Language: Английский

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Effectiveness of phytoconstituents and potential of phyto-nanomedicines combination to treat osteoarthritis

European Polymer Journal, Journal Year: 2024, Volume and Issue: 215, P. 113243 - 113243

Published: July 1, 2024

Osteoarthritis (OA) is a well-known degenerative joint disease recognized by the deterioration of cartilage in joints, leading to pain and reduced mobility. Traditional treatments for OA include management, physical therapy, severe cases, replacement surgery. In recent years, there has been growing interest exploring potential phytoconstituents nanomedicines combined treating OA. Furthermore, with increasing amount study this field, now opportune time widespread use plant-derived medications as complementary alternative medical therapies be acknowledged used more efficient treatment human ailments like Combining nanomedicine technology (phyto-nanomedicine) can potentially enhance their effectiveness The phyto-nanomedicines many advantages, including enhanced permeability, increased bioavailability, sustained/controlled drug release at site, decreased adverse effects, possible combination treatment. It's important note that while promising preclinical some clinical evidence regarding phyto-nanomedicine treatment, further research needed establish safety efficacy conclusively. review, treat combining phytomedicines nanoparticulate delivery former therapeutic discussed detail. we have also described briefly on application organ-on-chip and/or on-chip models accelerate identification novel evaluate potency

Language: Английский

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Efficacy and Safety of Two Chondroprotective Supplements in Patients With Knee Osteoarthritis: A Randomized, Single-Blind, Pilot Study

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: April 4, 2024

Background: Hyaluronic acid (HA), glucosamine (Glc), and chondroitin sulfate (CS) are key ingredients commonly incorporated into dietary chondroprotective supplements for the management of osteoarthritis (OA). Despite their widespread use, there is a paucity published data regarding efficacy safety, necessitating rigorous investigation in clinical settings. To address this knowledge gap, we conducted randomized, single-blind pilot study to evaluate effects two commercially available multi-ingredient on patients with mild-to-moderate knee OA. Methods: A total 51 diagnosed OA were enrolled four-week randomized allocated equally (1:1:1 ratio) three groups: control group (n = 17) that received no treatment, an HA given Syalox® 300 Plus (1 tablet/day) containing (300 mg) Boswellia serrata extract (100 mg), Glc + CS Cartijoint® Forte (415 (400 curcuminoids from rhizomes Curcuma longa L (50 mg). Physicians conducting evaluations blinded assignments, whereas not. All participants underwent assessments pain relief, functional capacity improvement, serum adropin levels, emerging biomarker OA, at baseline after intervention period. Results: Both groups exhibited improvements end relative baseline, statistically significant differences (p < 0.05) observed rest, during movement, range motion, overall Western Ontario McMaster Universities Osteoarthritis Index (WOMAC) scores, including its pain, stiffness, physical function subscales. Notably, outperformed alleviation WOMAC subscale, all being 0.05). Additionally, both showed elevation levels 0.05), experiencing more substantial increase when compared limited number treatment-emergent adverse events. Conclusion: Oral supplementation either or demonstrated potential benefits managing symptoms was associated greater relief higher elevations supplementation. However, larger-scale longer-term studies necessary further safety these within arsenal

Language: Английский

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What improvements do general exercise training and traditional Chinese exercises have on knee osteoarthritis? A narrative review based on biological mechanisms and clinical efficacy

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: May 22, 2024

Background Knee osteoarthritis (KOA) is a disease that significantly affects the quality of life patients, with complex pathophysiology includes degeneration cartilage and subchondral bone, synovitis, associations mechanical load, inflammation, metabolic factors, hormonal changes, aging. Objective This article aims to comprehensively review biological mechanisms clinical effects general exercise training traditional Chinese exercises (such as Tai Chi Qigong) on treatment KOA, providing references for development prescriptions. Methods A systematic search databases including PubMed, Web Science, Google Scholar, China National Knowledge Infrastructure (CNKI) was conducted, reviewing studies randomized controlled trials (RCTs), observational studies, reviews, meta-analyses. Keywords included “knee osteoarthritis,” “exercise therapy,” “physical activity,” “traditional exercise.” Results conclusion General positively KOA by such promoting blood circulation, improving metabolism inflammatory enhancing expression anti-inflammatory cytokines, reducing cell Traditional exercises, like Qigong, benefit improvement symptoms tissue repair regulating immune function alleviating joint inflammation. Clinical have shown both types can improve physical function, life, pain relief in patients KOA. Both are non-pharmacological options effectively patients’ physiological life. Future research should further explore long-term these interventions develop personalized programs based specific needs patients.

Language: Английский

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Understanding tightened muscle in knee osteoarthritis and the impacts of Fu’s subcutaneous needling: A pilot trial with shear-wave elastography and near-infrared spectroscopy

Medicine, Journal Year: 2024, Volume and Issue: 103(21), P. e38274 - e38274

Published: May 24, 2024

Given the scarce reports on interplay between Fu's subcutaneous needling (FSN), tightened muscle, and therapeutic effects, we developed a clinical research protocol to synchronously collect data efficacy muscle characteristics in patients with knee osteoarthritis, exploring mechanism of FSN action. The primary aim was assess feasibility safety this protocol, guiding future trials their sample size calculations.

Language: Английский

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