A Comprehensive Review of Free Radicals, Oxidative Stress, and Antioxidants: Overview, Clinical Applications, Global Perspectives, Future Directions, and Mechanisms of Antioxidant Activity of Flavonoid Compounds

Journal of Chemistry, Journal Year: 2024, Volume and Issue: 2024, P. 1 - 21

Published: May 31, 2024

Absorption​ of free radicals in the body cannot be done by antioxidant compounds originating from human body, so exogenous antioxidants are required to help their natural action. Oxidative stress can caused an imbalance radical inhibitors and accumulation that enter cellular structures. Synthetic found external not primary choice because they harmful carcinogenic. Therefore, using ingredients provides a necessary alternative constructing novel antioxidants. Recent studies have highlighted critical analysis evaluation flavonoids unique class secondary metabolites plants used communities as traditional therapeutics with proven bioactivity. This could support new discoveries based on various herbal medicines addition, functional effectiveness against radicals. In this review, there several strengths discussion. First, study takes comprehensive approach covering aspects, including properties sources radicals, oxidative relation different diseases, defense mechanisms, specific mechanisms flavonoids. Second, focus antioxidants, especially flavonoids, also discussion about clinical applications studies, limitations, global perspectives, future research directions become references selection medicines. But, constraints should considered when interpreting findings review. mechanism is only discussed general one example compound (flavonoid) has potential antioxidant. lack regarding relationship between diseases Third, limited number investigated some discussed.

Language: Английский

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Integrative Metabolomic and Lipidomic Signatures of SARS-CoV-2 VOCs: Correlations with Hematological and Biochemical Markers

Journal of Proteome Research, Journal Year: 2025, Volume and Issue: unknown

Published: May 19, 2025

In the present study, we investigated biochemical, hematological, lipidomic, and metabolomic alterations associated with different SAR-CoV-2 variants of concern (VOCs), such as WT, α, β, γ, δ, well their impact on COVID-19 severity. Across first second waves in India, a machine learning approach was used 3134 patients, nine critical biochemical hematological parameters, namely, C-reactive protein (CRP), D-dimer, ferritin, neutrophil, WBC count, lymphocyte, urea, creatine, lactate dehydrogenase (LDH), were identified. Furthermore, through metabolic lipidomic profiles lung colon cells transfected spike VOCs, notable dysregulation exhibited by delta variant correlated characteristic pathways catecholamine thyroid hormone synthesis. A corroborating meta-analysis also highlighted involvement urea amino acid metabolism pathways. Overall, our study provides crucial insights into disruptions caused contributing to better understanding pathogenesis development targeted interventions.

Language: Английский

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Remdesivir and the Liver: A Concise Narrative Review of Remdesivir-Associated Hepatotoxicity in Patients Hospitalized Due to COVID-19

Pharmacoepidemiology, Journal Year: 2024, Volume and Issue: 3(1), P. 69 - 81

Published: Feb. 13, 2024

Severe acute respiratory syndrome coronavirus 2 has infected millions of people, but about 20% individuals do not develop symptoms. COVID-19 is an inflammatory disease that affects a portion with the virus and it associated liver injury other complications, leading to hospitalization, critical illness, death. Remdesivir antiviral agent used for treatment hospitalized patients improve time recovery, reduce duration mechanical ventilation, decrease need supplemental oxygen, risk mortality. Remdesivir-associated hepatotoxicity been observed as increased transaminases more than five times upper limit normal in COVID-19, causality proven. It generally difficult distinguish between remdesivir-associated COVID-19-induced hepatotoxicity. The purpose this review evaluate evidence Current suggests elevated enzymes are likely be due infection remdesivir, 5-day course remdesivir seems safe regard

Language: Английский

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A tri-light warning system for hospitalized COVID-19 patients: Credibility-based risk stratification for future pandemic preparedness

European Journal of Radiology Open, Journal Year: 2024, Volume and Issue: 13, P. 100603 - 100603

Published: Oct. 17, 2024

Language: Английский

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Factors Associated with Length of Hospitalization in Patients with Diabetes and Mild COVID-19: Experiences from a Tertiary University Center in Serbia

Medicina, Journal Year: 2024, Volume and Issue: 60(5), P. 788 - 788

Published: May 9, 2024

: During the COVID-19 pandemic, there was an increased number of hospitalized COVID-19-positive patients suffering from type 2 diabetes mellitus (T2DM). The objective this research study to explore factors associated with length hospitalization T2DM and mild form COVID-19.

Language: Английский

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