The Roles of Forkhead Box O3a (FOXO3a) in Bone and Cartilage Diseases – A Narrative Review

Drug Design Development and Therapy, Journal Year: 2025, Volume and Issue: Volume 19, P. 1357 - 1375

Published: Feb. 1, 2025

Bone and cartilage diseases are significantly associated with musculoskeletal disability. However, no effective drugs available to cure them. FOXO3a, a member of the FOXO family, has been implicated in cell proliferation, ROS detoxification, autophagy, apoptosis. The biological functions FOXO3a can be modulated by post-translational modifications (PTMs), such as phosphorylation acetylation. Several signaling pathways, MAPK, NF-κB, PI3K/AKT, AMPK/Sirt1 have development bone mediating expression FOXO3a. In particular, acts transcriptional factor various genes, MnSOD, CAT, BIM, BBC3, CDK6. plays critical role metabolism cartilage. this article, we mainly discussed diseases, osteoporosis (OP), osteoarthritis (OA), rheumatoid arthritis (RA), ankylosing spondylitis (AS), intervertebral disc degeneration (IDD). promote osteogenic differentiation, induce osteoblast inhibit osteoclast activity, suppress chondrocyte apoptosis, reduce inflammatory responses. Collectively, up-regulation shows beneficial effects, become potential target for diseases.

Language: Английский

The dual missions of FoxO3a in inflammatory diseases: Regulation of antioxidant enzymes and involvement in programmed cell death

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 151, P. 114369 - 114369

Published: March 2, 2025

Language: Английский