Ketogenic Diet and Breast Cancer: Recent Findings and Therapeutic Approaches

Nutrients, Journal Year: 2023, Volume and Issue: 15(20), P. 4357 - 4357

Published: Oct. 13, 2023

Breast cancer (BC), a complex disease with several influencing factors, is significantly impacted by dietary habits. The ketogenic diet (KD), characterized high fat and low carbohydrate intake, has gained attention as potential therapeutic approach, but its effects on BC remain unclear. This review seeks to summarize the current knowledge principles of KD, metabolic influence cells, findings recent clinical trials, in order elucidate role KD management. For these purposes, comprehensive literature was conducted selecting preclinical studies that investigate relationship between BC. selection criteria prioritized exploring KD's cells trials involving reviewed provide diverse range findings, some suggesting benefits inhibiting tumor growth improving treatment response. However, robust providing clear evidence efficacy standalone approach are still lacking. There also significant concerns regarding safety long-term sustained ketosis patients. remains an area active research debate. While preliminary promising, definitive conclusions hindered inconsistent results limited human trial data. Future research, specifically well-structured, large-scale necessary understanding treatment. Until then, caution should be exercised application, patients continue prioritizing evidence-based, standard-of-care treatments.

Language: Английский

Melatonin and vitamin D as potential synergistic adjuvants for cancer therapy (Review)

International Journal of Oncology, Journal Year: 2024, Volume and Issue: 65(6)

Published: Oct. 22, 2024

Significant advancements have been made in cancer therapy; however, limitations remain with some conventional approaches. Adjuvants are agents used alongside primary treatments to enhance their efficacy and the treatment outcomes of patients. Modern lifestyles contribute deficiencies melatonin vitamin D. Limited sun exposure affects D synthesis, artificial light at night suppresses production. Both possess anti‑inflammatory, immune‑boosting anticancer properties, rendering them potential adjuvants interest. Studies suggest supplementation may address antioxidant imbalances lip, oral pharyngeal cancers. Moreover, promising results from breast, head neck, brain, osteosarcoma research indicate for tumor growth inhibition, improved survival, a better quality life patients cancer. The radioprotective properties another exciting area exploration, potentially enhancing radiotherapy effectiveness while reducing side effects. For its part, sleep‑promoting effects indirectly benefit by influencing immune system. Thus, prevalence highlights importance supplementation, as lower levels can worsen side‑effects treatments. present review explores combining synergistic therapy. These shown promise individually prevention treatment, combined warrant investigation. Therefore, large‑scale controlled trials crucial definitively determine optimal dosage, safety this combination improving lives

Language: Английский

The status of serum 25(OH)D levels is related to breast cancer

Cancer Treatment and Research Communications, Journal Year: 2024, Volume and Issue: 42, P. 100870 - 100870

Published: Jan. 1, 2024

Breast cancer is the second most common among women and leading cause of cancer-related mortality in this population. Numerous factors have been identified as either risk or protective for breast cancer. However, role Vitamin D (Vit. D) remains contentious, with conflicting findings literature. The present study aimed to compare serum Vit. levels between without This cross-sectional included 40 diagnosed cancer, referred Mahdia Hamadan Radiotherapy Center 2022. These participants were matched age- level-matched Serum measured using ELISA method. Statistical analysis was performed SPSS version 26, a significance threshold set at 95% confidence level. mean ± standard deviation 31.9 28.27 ng/mL 37.98 15.89 ng/mL, respectively (P = 0.024). prevalence insufficiency 50% group 27.5% control group, while 72.5% had sufficient 0.008). In lower significantly associated educational < 0.001), economic social status 0.001). A weak positive correlation observed patient age (r 0.162, P 0.152). significant difference suggests that deficiency may be risk. support hypothesis improving could potentially reduce incidence

Language: Английский