International Immunopharmacology, Journal Year: 2024, Volume and Issue: 144, P. 113676 - 113676
Published: Nov. 23, 2024
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Aug. 23, 2024
Abstract Alzheimer’s disease (AD) stands as the predominant form of dementia, presenting significant and escalating global challenges. Its etiology is intricate diverse, stemming from a combination factors such aging, genetics, environment. Our current understanding AD pathologies involves various hypotheses, cholinergic, amyloid, tau protein, inflammatory, oxidative stress, metal ion, glutamate excitotoxicity, microbiota-gut-brain axis, abnormal autophagy. Nonetheless, unraveling interplay among these pathological aspects pinpointing primary initiators require further elucidation validation. In past decades, most clinical drugs have been discontinued due to limited effectiveness or adverse effects. Presently, available primarily offer symptomatic relief often accompanied by undesirable side However, recent approvals aducanumab ( 1 ) lecanemab 2 Food Drug Administration (FDA) present potential in disrease-modifying Nevertheless, long-term efficacy safety need Consequently, quest for safer more effective persists formidable pressing task. This review discusses pathogenesis, advances diagnostic biomarkers, latest updates trials, emerging technologies drug development. We highlight progress discovery selective inhibitors, dual-target allosteric modulators, covalent proteolysis-targeting chimeras (PROTACs), protein-protein interaction (PPI) modulators. goal provide insights into prospective development application novel drugs.
Language: Английский
Citations
135
International Immunopharmacology, Journal Year: 2025, Volume and Issue: 153, P. 114442 - 114442
Published: March 19, 2025
Language: Английский
Citations
1
Brain Sciences, Journal Year: 2023, Volume and Issue: 14(1), P. 19 - 19
Published: Dec. 23, 2023
The term “neuroinflammation” defines the typical inflammatory response of brain closely related to onset many neurodegenerative diseases (NDs). Neuroinflammation is well known, but its mechanisms and pathways are not entirely comprehended. Some progresses have been achieved through efforts research. Consequently, new cellular molecular mechanisms, diverse conventional, emerging. In listing some those that will be subject our description discussion, essential important roles peripheral infiltrated monocytes clonotypic cells, alterations in gut–brain axis, dysregulation apelinergic system, endothelial glycocalyx component neuronal vascular units, variations expression genes levels encoding molecules by action microRNAs (miRNAs), or other epigenetic factors distinctive transcriptional factors, as role autophagy, ferroptosis, sex differences, modifications circadian cycle. Such can add significantly understanding complex etiological puzzle neuroinflammation ND. addition, they could represent biomarkers targets ND, which increasing elderly.
Language: Английский
Citations
20
International Immunopharmacology, Journal Year: 2024, Volume and Issue: 141, P. 112936 - 112936
Published: Aug. 19, 2024
Language: Английский
Citations
4
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9475 - 9475
Published: Aug. 31, 2024
Alzheimer's disease (AD), the leading cause of dementia, is a multifactorial influenced by aging, genetics, and environmental factors. miRNAs are crucial regulators gene expression play significant roles in AD onset progression. This exploratory study analyzed levels 28 genes 5 (miR-124-3p, miR-125b-5p, miR-21-5p, miR-146a-5p, miR-155-5p) related to pathology neuroimmune responses using RT-qPCR. Analyses were conducted prefrontal cortex (PFC) hippocampus (HPC)
Language: Английский
Citations
4
Biomarkers in Neuropsychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 100120 - 100120
Published: Jan. 1, 2025
Language: Английский
Citations
0
Open Life Sciences, Journal Year: 2025, Volume and Issue: 20(1)
Published: Jan. 1, 2025
Abstract Neuroinflammation represents a critical pathway in the brain for clearance of foreign bodies and maintenance homeostasis. When neuroinflammatory process is dysregulate, such as over-activation microglia, which results excessive accumulation free oxygen inflammatory factors brain, among other factors, it can lead to an imbalance homeostasis development various diseases. Recent research has indicated that numerous neurodegenerative diseases closely associated with neuroinflammation. The pathogenesis neuroinflammation intricate, involving alterations genes proteins, well activation inhibition signaling pathways. Furthermore, inflammation result neuronal cell apoptosis, further exacerbate extent disease. This article presents summary recent studies on relationship between apoptosis caused by aim identify link two provide new ideas targets exploring pathogenesis, prevention treatment
Language: Английский
Citations
0
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 27, 2025
Alzheimer's disease (AD) is an age-related neurological illness that poses a significant hazard to human health. A fat-soluble compound called tanshinones was isolated from Danshen, traditional Chinese herb. Recent years have seen reports of clinical trials examining the effects on cognitive impairment among individuals with AD, as well publication pertinent basic research. Tanshinones are not yet commonly utilized in therapeutic treatment and effectiveness program for AD adequately supported by evidence. To assess impact experimental rodent models we carried out systematic review this work. All relevant studies usage model animals published PubMed, Cochrane Library, Web Science, EMBASE, Biomedicine Database, China National Knowledge Infrastructure before 8 September 2024, were systematically retrieved. methodological quality, CAMARADES checklist used. Meta-analysis calculated graphed Stata 14.0 software. For each outcome every study, standard mean difference (SMD) 95% confidence interval (CI) effect size calculated. Fourteen included study. Compared group without intervention, significantly reduced number escape latency [SMD = -2.082, CI (-2.481, -1.683), p < 0.001]. also increased times platform crossing 1.464, (1.183, 1.744), 0.001] time target quadrants 2.703, (2.132, 3.275), thought positive according findings However, level quality research may accuracy outcomes. Thus, more high-quality randomized controlled animal required guide future scientific identifier CRD42024557980.
Language: Английский
Citations
0
Archives of Medical Science, Journal Year: 2025, Volume and Issue: unknown
Published: March 21, 2025
Introduction Alzheimer’s disease (AD), the most prevalent type of dementia among older individuals, is characterized by severe neurodegeneration with symptoms progressive loss cognitive capacity. We aimed to investigate effects curcumin (Curc) and Inula viscosa (IV) plant extracts on apoptosis oxidative stress in an amyloid-β (Aβ<i></i>)-induced vitro AD model. Material methods The human glioblastoma cell line (U87) was treated Aβ produce Treatment groups were: + Curc, IV, IV Curc. Cell viability assay performed analyze cytotoxicity. Caspase-3 (CASP3) levels were measured evaluate apoptosis. For stress, glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD), total antioxidant (TAS), oxidant (TOS) analyzed spectrophotometrically. Results Combinatory application Curc post-Aβ treatment increased U87 cells. Aβ-upregulated CASP3 markedly reduced upon co-treatment. Anti-oxidant parameters, i.e., SOD, CAT, GPx, TAS levels, significantly elevated Curc-treated group compared group. TOS level after exposure returned its basal Conclusions co-treatment apoptosis-related supported activity Aβ-induced model can be a promising therapeutic strategy against AD.
Language: Английский
Citations
0
Neurogenetics, Journal Year: 2025, Volume and Issue: 26(1)
Published: April 1, 2025
Language: Английский
Citations
0