Exercise-induced upregulation of TRIM9 attenuates neuroinflammation in Alzheimer’s disease-like rat DOI
Xinyang Zhang, Jiahao Zhang, Xiaochuan Li

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 144, P. 113676 - 113676

Published: Nov. 23, 2024

Language: Английский

Network Toxicology and Molecular Docking Strategy for Analyzing the Toxicity and Mechanisms of Bisphenol A in Alzheimer's Disease DOI
Sumei Xu, Liping Jiang, Zhuo Zhang

et al.

Journal of Biochemical and Molecular Toxicology, Journal Year: 2025, Volume and Issue: 39(4)

Published: April 1, 2025

ABSTRACT Alzheimer's disease (AD) is a chronic and progressive neurodegenerative disorder marked by memory deterioration cognitive impairment. Bisphenol A (BPA), common environmental pollutant, has been linked to neurotoxicity may contribute AD development. This study aims uncover potential toxicological targets molecular mechanisms of BPA‐induced AD. BPA's neurotoxic effects were predicted using ProTox ADMETlab. Target prediction for BPA was conducted through the STITCH Swiss Prediction platforms, while AD‐related compiled from GeneCards, OMIM, Therapeutic Database (TTD). Protein‐protein interaction (PPI) networks constructed STRING visualized in Cytoscape, gene ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway analyses performed. Molecular docking employed evaluate binding interactions between identified core targets. Through systematic bioinformatics analyses, 137 candidate BPA‐elicited identified. Screening via PPI network analysis highlighted five key targets: STAT3, AKT1, INS, EGFR, PTEN. GO KEGG enrichment revealed significant involvement oxidative stress, neuronal apoptosis, processes, pathways such as PI3K/AKT, MAPK, lipid atherosclerosis, signaling. simulations confirmed strong affinities these sheds light on underlying context provides foundation further research into preventive therapeutic strategies. The integration toxicology offers robust framework unraveling toxic uncharacterized chemical agents.

Language: Английский

Citations

0
Identification of Stable Housekeeping Genes for miRNA Expression Studies in a Mouse Unilateral Ureteral Obstruction Model DOI

Bruno Aristides dos Santos Bronel,

Ana Carolina Anauate, José Antonio Novaes da Silva

et al.

Biochemical Genetics, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Language: Английский

Citations

0
Decoding Paradoxical Links of Cytokine Markers in Cognition: Cross talk between Physiology, Inflammaging, and Alzheimer’s Disease- Related Cognitive Decline DOI
Hiba Khan,

Talib Naseem,

Pooja Kaushik

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 101, P. 102535 - 102535

Published: Oct. 6, 2024

Language: Английский

Citations

2
Combination of network pharmacology, in vitro experiments and molecular dynamic simulations revealed anti-inflammatory molecular mechanism of the shrub Metapanax delavayi DOI Creative Commons
Chunyan Zhao, Zelin Li, Yusuf Chisti

et al.

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 121, P. 106440 - 106440

Published: Sept. 2, 2024

Language: Английский

Citations

1
Exercise-induced upregulation of TRIM9 attenuates neuroinflammation in Alzheimer’s disease-like rat DOI
Xinyang Zhang, Jiahao Zhang, Xiaochuan Li

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 144, P. 113676 - 113676

Published: Nov. 23, 2024

Language: Английский

Citations

0