Antioxidants and Redox Signaling,
Journal Year:
2024,
Volume and Issue:
41(13-15), P. 976 - 991
Published: July 13, 2024
Numerous
disorders
are
linked
to
ferroptosis,
a
form
of
programmed
cell
death
triggered
by
lipid
peroxidation
accumulation
rather
than
apoptosis.
Inflammation
is
the
body's
defensive
response
stimuli
and
also
caused
inflammatory
chemicals
that
can
harm
body.
The
treatment
diseases
focusing
on
signaling
pathways
mechanisms
ferroptosis
has
emerged
as
new
area
worthy
extensive
research.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
179, P. 117323 - 117323
Published: Aug. 28, 2024
Recently,
increased
attention
has
been
focused
on
the
regulatory
mechanism
and
potential
clinical
application
of
ferroptosis
in
cancer
cells,
especially
therapy-related
ferroptosis.
However,
treatment-related
prospects
strategies
for
future
treatment
still
require
further
clarification.
This
review
highlights
molecular
relationships
between
different
antitumour
drugs,
including
commonly
used
chemotherapy
radiation
therapy
vitamins,
also
proposes
treatments
that
involve
ferroptosis,
with
an
aim
to
develop
a
new
strategy
transformative
emerging
field
improve
therapy.
Spontaneous
intracerebral
hemorrhagic
stroke
(ICH)
is
a
highly
aggressive
disease,
with
high
incidence
and
mortality
rate.
Iron
deposition
following
ICH
leads
to
oxidative
damage
motor
dysfunction,
significantly
impacting
the
overall
quality
of
life
for
those
affected.
Here,
polyphenolic
nanomedicine,
catechin-based
polyphenol
nanoparticles
surface-modified
by
thiol-terminated
poly(ethylene
glycol)
(CNPs@PEG),
was
developed
through
polymerization
self-assembly
catechin,
natural
compound
in
tea.
Due
its
potent
antioxidant
metal-chelating
properties,
CNPs@PEG
effectively
maintained
blood-brain
barrier
integrity,
reduced
brain
edema,
increased
survival
rate
mice
cerebral
hemorrhage
markedly
improved
neurological
deficits
after
ICH.
Mechanistically,
accomplishes
this
chelating
iron,
enhancing
tissue
capacity,
reducing
stress,
inhibiting
iron
deposition.
This
approach
holds
promise
as
targeted
therapeutic
strategy
addressing
other
conditions
associated
overload.
International Journal of Nanomedicine,
Journal Year:
2025,
Volume and Issue:
Volume 20, P. 2521 - 2553
Published: Feb. 1, 2025
Exosomes
(Exos)
derived
from
human
umbilical
cord
mesenchymal
stem
cells
(hUC-MSCs)
hold
great
potential
for
treating
bronchopulmonary
dysplasia
(BPD);
however,
safety
concerns
and
effects
of
intranasal
administration
remain
unexplored.
This
study
aimed
to
explore
the
hUC-MSCs
Exos
investigate
efficacy
bio-distribution
repeated
in
neonatal
BPD
models.
Characteristics
were
analyzed.
A
subcutaneous
tumor
formation
assay
using
a
single
dose
or
was
conducted
Crl:NU-Foxn1nu
mice.
Vital
signs,
biochemical
indices,
pathological
alterations,
18F-FDG
microPET/CT
analysis
examined.
Pulmonary
pathology,
three-dimensional
reconstructions,
ultrastructural
structures,
vivo
ex
imaging
analyses,
enzyme-linked
immunoassay
assays,
reverse
transcription-quantitative
polymerase
chain
reaction
analyses
lung
tissues
all
documented
following
administration.
satisfied
specifications.
mice
did
not
exhibit
overt
toxicity
carcinogenicity
after
60
days
observation.
Repeated
effectively
alleviated
injuries,
restored
pulmonary
ventilation
reconstruction,
recovered
endothelial
cell
layer
integrity
analysis.
steadily
accumulated
postnatal
day
1
14.
also
interrupted
epithelial-mesenchymal
transition
inflammation
reactions
As
nanoscale,
non-cellular
therapy,
an
effective,
noninvasive
treatment
BPD.
approach
free
toxic,
tumorigenic
risks
repaired
alveolar
damage
while
interrupting
with
Journal of Translational Medicine,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Feb. 27, 2025
Radiation-induced
lung
injury
(RILI)
is
the
most
common
complication
experienced
by
patients
with
thoracic
tumors
after
radiotherapy.
Among
receiving
tumor
radiotherapy,
14.6–37.2%
develop
RILI.
RILI
characterized
an
acute
inflammatory
response;
however,
exact
mechanism
remains
unclear
and
ideal
drug
still
lacking.
In
this
study,
we
investigated
protective
effects
of
flagellin
A
linked
C-
N-terminal
ends
(FlaA
N/C)
against
development
Mice
bronchial
epithelial
cells
were
exposed
to
radiation
(15
Gy)
FlaA
N/C
treatment.
Lung
injury,
cell
assessed
histological
evaluation
in
vivo
viability
death
detection
vitro.
Pyroptosis
was
western
blotting
(WB),
immunofluorescence
(IF),
immunohistochemistry
(IHC).
To
explore
molecular
mechanisms
which
inhibits
RILI,
conditional
Beclin
1
(Beclin1+/−)
NLR
family
CARD
domain-containing
protein
4
(Nlrc4)-knockout
(Nlrc4−/−)
mice
generated.
An
autophagy
inhibitor
used
for
vitro
assays,
pyroptosis
indicators
detected.
Data
analyzed
using
one-way
analysis
variance.
attenuated
radiation-induced
tissue
damage,
pro-inflammatory
cytokine
release,
viability,
death,
Mechanistically,
activated
neuronal
apoptosis
inhibitory
(NAIP)/NLRC4/apoptosis-associated
speck-like
containing
a
caspase
recruitment
domain
(ASC)
inflammasome,
then
degraded
during
1-mediated
autophagy.
Deletion
D0
reversed
effect
on
Similarly,
Nlrc4-knockout
or
inhibition
eliminated
pyroptosis.
These
results
indicate
that
attenuates
promoting
NAIP/NLRC4/ASC
inflammasome
inhibiting
This
study
provides
potential
approach
intervention.
Frontiers in Cell and Developmental Biology,
Journal Year:
2025,
Volume and Issue:
13
Published: March 5, 2025
Ferroptosis
is
a
novel
form
of
cell
death
that
uniquely
requires
iron
and
characterized
by
accumulation,
the
generation
free
radicals
leading
to
oxidative
stress,
formation
lipid
peroxides,
which
distinguish
it
from
other
forms
death.
The
regulation
ferroptosis
extremely
complex
closely
associated
with
spectrum
diseases.
Sirtuin
1
(SIRT1),
NAD
+
-dependent
histone
deacetylase,
has
emerged
as
pivotal
epigenetic
regulator
potential
regulate
through
wide
array
genes
intricately
metabolism,
homeostasis,
glutathione
biosynthesis,
redox
homeostasis.
This
review
provides
comprehensive
overview
specific
mechanisms
SIRT1
regulates
explores
its
therapeutic
value
in
context
multiple
disease
pathologies,
highlighting
significance
SIRT1-mediated
treatment
strategies.
International Journal of Immunopathology and Pharmacology,
Journal Year:
2025,
Volume and Issue:
39
Published: March 1, 2025
Objective:
Acute
respiratory
distress
syndrome
(ARDS)
is
a
severe
pulmonary
condition
characterized
by
inflammation
and
lung
damage,
frequently
resulting
in
poor
clinical
outcomes.
Recent
studies
suggest
that
the
gut-lung
axis,
mediated
gut
microbiota,
critical
ARDS
progression.
This
study
investigates
therapeutic
potential
of
fecal
microbiota
transplantation
(FMT)
an
rat
model
(
n
=
6).
Introduction:
The
pathogenesis
involves
complex
interactions
between
lungs
gut,
with
playing
key
role.
Understanding
effects
FMT
on
function
may
provide
new
strategies
for
management.
Methods:
Sprague-Dawley
rats
were
pre-treated
broad-spectrum
antibiotic
cocktail
to
create
germ-free
state
subsequently
exposed
intranasal
lipopolysaccharide
induce
ARDS.
then
received
treatment.
Lung
samples
analyzed
using
histopathology
transcriptomics.
Fecal
16S
rRNA
sequencing
metabolomics.
Results:
treatment
significantly
reduced
injury
improved
function,
as
evidenced
increased
partial
pressure
arterial
oxygen
(PaO
2
)
decreased
carbon
dioxide
(PaCO
).
also
altered
composition
regulating
Akkermansia
Lactobacillus
,
restoring
abundance
genera
such
Muribaculaceae
Clostridia_UCG-014
Prevotella
Adlercreutzia
while
reducing
Romboutsia
.
restored
metabolic
pathways
involved
lipid
metabolism,
amino
acid
biosynthesis,
immune
regulation,
including
modulation
like
mTOR
signaling.
These
alterations
contribute
function.
Conclusion:
findings
indicate
exert
its
beneficial
modulating
enhancing
responses.
However,
given
this
remains
preclinical
stage,
further
validation
necessary
before
considering
application.
World Journal of Emergency Medicine,
Journal Year:
2024,
Volume and Issue:
15(2), P. 111 - 111
Published: Jan. 1, 2024
Sepsis-related
acute
respiratory
distress
syndrome
(ARDS)
has
a
high
mortality
rate,
and
no
effective
treatment
is
available
currently.
Quercetin
natural
plant
product
with
many
pharmacological
activities,
such
as
antioxidative,
anti-apoptotic,
anti-inflammatory
effects.
This
study
aimed
to
elucidate
the
protective
mechanism
of
quercetin
against
sepsis-related
ARDS.
