Stem cell therapy for the treatment of psychiatric disorders: a real hope for the next decades

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 7, 2025

In this review, it is evaluated the progress in application of stem cell therapy to ameliorate symptoms bipolar disorder, major depression, schizophrenia, and autism. These disorders are highly prevalent clinical medicine responsible for high levels psychosocial disability among patients. All them share common biomedical features, such as complex variable genetic substrates, significant susceptibility environmental changes, insufficient knowledge their pathogenesis. addition, responsiveness patients pharmacological treatment heterogeneous, some cases, no available. Therefore, development cell-based regenerative its possible combination with emerging therapeutic approaches that promote neural plasticity expected advance neuropsychiatry next few decades.

Language: Английский

Altered PLCβ/IP3/Ca2+ Signaling Pathway Activated by GPRCs in Olfactory Neuronal Precursor Cells Derived from Patients Diagnosed with Schizophrenia

Biomedicines, Journal Year: 2024, Volume and Issue: 12(10), P. 2343 - 2343

Published: Oct. 15, 2024

: Schizophrenia (SZ) is a multifactorial chronic psychiatric disorder with worldwide prevalence of 1%. Altered expression PLCβ occurs in SZ patients, suggesting alterations the PLCβ/IP

Language: Английский