Exploring the association between melatonin and nicotine dependence (Review) DOI Creative Commons
Vasiliki Georgakopoulou, Pagona Sklapani, Νικόλαος Τράκας

et al.

International Journal of Molecular Medicine, Journal Year: 2024, Volume and Issue: 54(4)

Published: July 30, 2024

Due to the addictive qualities of tobacco products and compulsive craving dependence associated with their use, nicotine continues be a serious public health concern on global scale. Despite awareness risks, addiction contributes numerous acute chronic medical conditions, including cardiovascular disease, respiratory disorders cancer. The nocturnal secretion pineal melatonin, known as 'hormone darkness', influences circadian rhythms is implicated in addiction‑related behaviors. Melatonin receptors are found throughout brain, influencing dopaminergic neurotransmission potentially attenuating nicotine‑seeking behavior. Additionally, antioxidant properties melatonin may mitigate oxidative stress from exposure, reducing cellular damage lowering risk nicotine‑related issues. In addition its effects rhythmicity, acting via specific neural sleep mood, provides neuroprotection. Disruptions signaling contribute disturbances mood disorders, highlighting potential therapeutic role psychiatric conditions. influence neurotransmitter systems involved addiction, such dopaminergic, glutamatergic, serotonergic endogenous opioid systems. Preclinical studies suggest modulating reward processing, drug‑induced hyperactivity withdrawal symptoms. Chronotherapeutic approaches targeting show promise smoking cessation interventions. supplementation during periods heightened cravings alleviate symptoms reduce reinforcing nicotine. Further research required however, examine molecular mechanisms underlying melatonin‑nicotine association optimization Challenges include variability individual responses optimal dosing regimens identifying biomarkers treatment response. Understanding these complexities could lead personalized strategies improve outcomes.

Language: Английский

Efficacy of melatonin treatment in a cystic fibrosis mouse model of airway infection DOI Creative Commons
Kevin Schaefer,

Sara Rogers,

Zachary Faber

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 13, 2025

Approaches to mitigate the severity of infections and immune responses are still needed for treatment cystic fibrosis (CF) even with success highly effective modulator therapies. Previous studies identified reduced levels melatonin in a CF mouse model related circadian rhythm dysregulation. Melatonin is known have immunomodulatory properties it was hypothesized that would improve bacterial infection mice. Data demonstrate mice (G542X/G542X) treated (10 µg/mL) drinking water 10 weeks had improved airway clinical isolate Pseudomonas aeruginosa. Melatonin-treated exhibited clearance, inflammatory markers. Mice 1 week clearance but no improvement inflammation. Wild type (WT) control showed response suggesting eliciting CF-specific this model. The efficacy direct (1 µM) airways also tested found be ineffective. In conclusion, long-term systemic an therapy normalizes WT pattern.

Language: Английский

Citations

0
Post infectious fatigue and circadian rhythm disruption in long-COVID and other infections: a need for further research DOI Creative Commons

Achilleas Livieratos,

Steven W. Lockley, Sotirios Tsiodras

et al.

EClinicalMedicine, Journal Year: 2025, Volume and Issue: 80, P. 103073 - 103073

Published: Jan. 18, 2025

Language: Английский

Citations

0
Melatonin from Plants: Going Beyond Traditional Central Nervous System Targeting—A Comprehensive Review of Its Unusual Health Benefits DOI Creative Commons
Lucas Fornari Laurindo,

Otávio Augusto Garcia Simili,

Adriano Cressoni Araújo

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(2), P. 143 - 143

Published: Jan. 30, 2025

Melatonin is indispensable for the homeostasis of plants and animals. In humans, it can help prevent or be an adjuvant treatment several diseases mainly related to immune system, inflammation, oxidative stress. Moreover, a melatonin-rich diet linked health benefits, such as regulation circadian rhythm, immunological epilepsy control, delaying aging process, diminishing hormones cancer. This review aimed show effects melatonin in beyond its traditional use. The results showed present scavenging free radicals, reducing inflammatory cytokines, modulating system. improve insulin resistance, blood pressure, LDL-c, adipose tissue mass, adhesion molecules, endothelial impairment, plaque formation. These result neuro- cardioprotection, improvement liver diseases, rheumatoid arthritis, dermatitis, COVID-19, polycystic ovaries, sepsis. We conclude that plant benefit patients with many besides sleep problems neurodegeneration. Plant may more cost-effective fewer adverse events than synthetic. However, clinical trials should performed adequate doses, formulation, time.

Language: Английский

Citations

0
Programmed cell death and melatonin: A comprehensive review DOI

Mahdi Rafiyian,

Russel J. Reıter,

Sayyed Mehdi Rasooli Manesh

et al.

Functional & Integrative Genomics, Journal Year: 2024, Volume and Issue: 24(5)

Published: Sept. 24, 2024

Language: Английский

Citations

2
Exploring the association between melatonin and nicotine dependence (Review) DOI Creative Commons
Vasiliki Georgakopoulou, Pagona Sklapani, Νικόλαος Τράκας

et al.

International Journal of Molecular Medicine, Journal Year: 2024, Volume and Issue: 54(4)

Published: July 30, 2024

Due to the addictive qualities of tobacco products and compulsive craving dependence associated with their use, nicotine continues be a serious public health concern on global scale. Despite awareness risks, addiction contributes numerous acute chronic medical conditions, including cardiovascular disease, respiratory disorders cancer. The nocturnal secretion pineal melatonin, known as 'hormone darkness', influences circadian rhythms is implicated in addiction‑related behaviors. Melatonin receptors are found throughout brain, influencing dopaminergic neurotransmission potentially attenuating nicotine‑seeking behavior. Additionally, antioxidant properties melatonin may mitigate oxidative stress from exposure, reducing cellular damage lowering risk nicotine‑related issues. In addition its effects rhythmicity, acting via specific neural sleep mood, provides neuroprotection. Disruptions signaling contribute disturbances mood disorders, highlighting potential therapeutic role psychiatric conditions. influence neurotransmitter systems involved addiction, such dopaminergic, glutamatergic, serotonergic endogenous opioid systems. Preclinical studies suggest modulating reward processing, drug‑induced hyperactivity withdrawal symptoms. Chronotherapeutic approaches targeting show promise smoking cessation interventions. supplementation during periods heightened cravings alleviate symptoms reduce reinforcing nicotine. Further research required however, examine molecular mechanisms underlying melatonin‑nicotine association optimization Challenges include variability individual responses optimal dosing regimens identifying biomarkers treatment response. Understanding these complexities could lead personalized strategies improve outcomes.

Language: Английский

Citations

1