Microbial Pathogenesis, Journal Year: 2024, Volume and Issue: 197, P. 107014 - 107014
Published: Oct. 11, 2024
Language: Английский
Pathogens, Journal Year: 2025, Volume and Issue: 14(1), P. 43 - 43
Published: Jan. 8, 2025
PANoptosis is a newly identified programmed cell death pathway that integrates characteristics of apoptosis, pyroptosis, and necroptosis. It plays dual role in the host immune response to bacterial infections. On one hand, acts as protective mechanism by inducing infected cells eliminate pathogens releasing pro-inflammatory cytokines amplify response. other bacteria can exploit evade defenses. This nature underscores potential target for developing novel therapies against review summarizes molecular mechanisms PANoptosis, along with crosstalk integration different pathways various pathogens. We also discuss roles infectious diseases, including sepsis, pulmonary infections, intestinal Elucidating underlying how manipulate this offers critical insights into host-pathogen interactions. These provide foundation designing targeted antibacterial strategies, modulating inflammation, advancing precision medicine improve clinical outcomes.
Language: Английский
Citations
1
Seminars in Cancer Biology, Journal Year: 2024, Volume and Issue: 106-107, P. 106 - 122
Published: Sept. 17, 2024
Language: Английский
Citations
4
Biochemical Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 116961 - 116961
Published: April 1, 2025
Language: Английский
Citations
0
Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12
Published: April 29, 2025
Pulmonary arterial hypertension (PAH) is a serious condition marked by elevated pulmonary artery pressure, often progressing to right heart failure and high mortality. PANoptosis, an inflammatory form of programmed cell death, remains understudied in the context PAH. This study aims identify validate PANoptosis-related signature genes PAH using bioinformatics analysis alongside vivo vitro experiments, seeking uncover its potential role disease progression. PAH-related datasets PANoptosis-associated were sourced from Gene Expression Omnibus (GEO) database prior studies. Feature identified through weighted gene co-expression network (WGCNA), least absolute shrinkage selection operator (LASSO), random forest (RF) algorithms, with validation performed on external datasets. The immune landscape was characterized CIBERSORT algorithm, providing insights into composition expression further validated rat model fibroblasts (PAAFs), while hub functions investigated at cellular level Western blot, CCK-8, flow cytometry assays. Through integrated transcriptomic analysis, SFRP2 as feature related PANoptosis. Experimental conducted MCT-induced models TGF-β1-induced PAAFs, confirming SFRP2's regulating fibroblast proliferation anti-apoptotic processes. diagnostic derived dataset exhibited accuracy diagnosing PAH, infiltration highlighted dysregulation associated condition. biomarker for impacting resistance apoptosis, thus new prevention treatment.
Language: Английский
Citations
0
Cell Discovery, Journal Year: 2025, Volume and Issue: 11(1)
Published: May 5, 2025
Abstract Caspases are critical regulators of cell death, development, innate immunity, host defense, and disease. Upon detection pathogens, damage-associated molecular patterns, cytokines, or other homeostatic disruptions, immune sensors, such as NLRs, activate caspases to initiate distinct regulated death pathways, including non-lytic (apoptosis) lytic (pyroptosis PANoptosis) pathways. These pathways driven by specific distinguished their unique mechanisms, supramolecular complexes, enzymatic properties. Traditionally, classified either apoptotic (caspase-2, -3, -6, -7, -8, -9, -10) inflammatory (caspase-1, -4, -5, -11). However, extensive data from the past decades have shown that can also drive downstream sensing responses, in case caspase-3, -8. Therefore, more inclusive classification systems based on function, substrate specificity, presence pro-domains been proposed better reflect multifaceted roles caspases. In this review, we categorize into CARD-, DED-, short/no pro-domain-containing groups examine functions immunity along with structural active site/exosite properties substrates. Additionally, highlight emerging cellular homeostasis therapeutic targeting. Given clinical relevance across multiple diseases, improved understanding these proteins structure–function relationships is for developing effective treatment strategies.
Language: Английский
Citations
0
Microbial Pathogenesis, Journal Year: 2024, Volume and Issue: 197, P. 107014 - 107014
Published: Oct. 11, 2024
Language: Английский
Citations
2