Ferroptosis in Endometriosis: Traditional Chinese Medicine Interventions and Mechanistic Insights DOI

Dazhi Lan,

Shuping Huang, Jing Li

et al.

The American Journal of Chinese Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 24

Published: March 27, 2025

Endometriosis (EMS) is a chronic, estrogen-dependent inflammatory disease affecting 5–10% of women reproductive age, characterized by the growth endometrial tissue on outside uterus. The dysregulation iron metabolism leads to accumulation ions at lesion sites, resulting in oxidative stress and pro-inflammatory responses that promote progression EMS. mechanisms underlying ferroptosis EMS primarily involve accumulation, lipid peroxidation, loss glutathione peroxidase 4 activity. These confer resistance within ectopic tissues facilitate cell survival proliferation. Traditional Chinese medicine (TCM) has demonstrated therapeutic potential for modulating ferroptosis. Studies have shown TCM monomers may regulate transport proteins anti-oxidant defense mechanisms. formulas employ distinct treatment strategies depending stage EMS: early stages, they control growth, whereas later inhibit reduce inflammation order improve health slow progression. This study provides new perspective management summarizing role its pathological reviewing findings use regulating

Language: Английский

Ferroptosis in Endometriosis: Traditional Chinese Medicine Interventions and Mechanistic Insights DOI

Dazhi Lan,

Shuping Huang, Jing Li

et al.

The American Journal of Chinese Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 24

Published: March 27, 2025

Endometriosis (EMS) is a chronic, estrogen-dependent inflammatory disease affecting 5–10% of women reproductive age, characterized by the growth endometrial tissue on outside uterus. The dysregulation iron metabolism leads to accumulation ions at lesion sites, resulting in oxidative stress and pro-inflammatory responses that promote progression EMS. mechanisms underlying ferroptosis EMS primarily involve accumulation, lipid peroxidation, loss glutathione peroxidase 4 activity. These confer resistance within ectopic tissues facilitate cell survival proliferation. Traditional Chinese medicine (TCM) has demonstrated therapeutic potential for modulating ferroptosis. Studies have shown TCM monomers may regulate transport proteins anti-oxidant defense mechanisms. formulas employ distinct treatment strategies depending stage EMS: early stages, they control growth, whereas later inhibit reduce inflammation order improve health slow progression. This study provides new perspective management summarizing role its pathological reviewing findings use regulating

Language: Английский

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