The Regulatory Effects of Exercise and Metformin on Biomarkers in Obesity: A Focus on Uric Acid, Irisin, Adiponutrin, Adropin, and Copeptin

Medicina, Journal Year: 2025, Volume and Issue: 61(3), P. 399 - 399

Published: Feb. 25, 2025

Background and Objectives: Obesity has become one of the most significant health problems nowadays, with its prevalence rapidly increasing. Approaches such as diet exercise play an important role in treatment obesity. This study aimed to investigate responses uric acid, irisin, adiponutrin, adropin, copeptin levels metformin intervention Materials Methods: Thirty-six male Sprague–Dawley rats were randomly divided into seven groups: healthy control (HC), sham (S), obese (OC), (M), (E), + (ME), decapitation (D). After obesity was induced through a 12-week high-fat diet, underwent 4-week aerobic intervention. Results: Uric determined using ELISA method. Copeptin significantly decreased ME group (p < 0.001). Irisin increased E groups The notable increases adropin occurred acid highest OC but lower M Adiponutrin did not change response or > 0.05). Conclusions: These findings suggest that may effective management.

Language: Английский

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Metabolic Dysfunction-Associated Steatotic Liver Disease Induced by Microplastics: An Endpoint in the Liver–Eye Axis

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2837 - 2837

Published: March 21, 2025

There is a significant, rather than just anecdotal, connection between the liver and eyes. This evident in noticeable cases such as jaundice, where sclera has yellow tint. But this can be seen through even more subtle indicators, molecules known hepatokines. relationship not merely anecdotal; some studies, it referred to “liver–eye axis”. Ubiquitous environmental contaminants, microplastics (MPs), enter bloodstream human body conjunctival sac, nasolacrimal duct, upper respiratory tract mucosa. Once absorbed, these substances accumulate various organs cause harm. Toxic from surface of eye lead local oxidative damage by inducing apoptosis corneal cells, irregularly shaped microparticles exacerbate effect. Even other toxicants ocular may absorbed into distributed throughout body. Environmental toxicology presents challenge because many pollutants same route that used certain medications. Previous research indicated accumulation MPs play major role development chronic disease humans. It crucial investigate whether buildup potential fibrosis, or simply consequence conditions cirrhosis portal hypertension.

Language: Английский

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Measurement of serum adropin levels in chronic renal failure patients receiving routine hemodialysis treatment

Medicine, Journal Year: 2025, Volume and Issue: 104(12), P. e41860 - e41860

Published: March 21, 2025

The significance of adropin levels in chronic renal failure patients has not yet been established. This study’s objectives were to compare serum hemodialysis with and healthy as well the clinical parameters corresponding levels. total sample comprised 49 individuals 36 controls. We measured concentrations using enzyme-linked immunosorbent assay method analyzed various biochemical including creatinine, uric acid, C-reactive protein, albumin, parathyroid hormone, hemoglobin In there statistically significant lower determined at 522.7 ± 169.4 versus 789.6 259.3 ng/L, P < .01. Strong negative correlations observed between both creatinine ( r = −0.613, .001) hormone −0.621, .001). Additionally, moderate positive found albumin 0.534, 0.445, There also differences A1c control populations 5.7 1.8 5.2 0.5, .04 protein 21.8 28.9 1.4 2.6 mg/L, .01 respectively. These findings suggest that reduced are significantly associated markers dysfunction, inflammation, nutritional status, indicating its potential role pathophysiology failure.

Language: Английский

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Adropin as a protective agent against renal ischemia-reperfusion injury induced by suprarenal aortic cross-clamping in rats

BMC Nephrology, Journal Year: 2025, Volume and Issue: 26(1)

Published: March 26, 2025

The development of protective therapeutic strategies against acute kidney injury associated with suprarenal aneurysms, renal artery occlusive disease, and aortic reconstruction is paramount importance. Adropin a peptide hormone that has been shown to protect vascular endothelial cells reduce oxidative stress, apoptosis, inflammation. Therefore, in addition its metabolic effects, adropin potential as agent ischemia-reperfusion injury. This study aims investigate the effects adropine on (IR) under cross clamp. Male Sprague Dawley rats were divided into six groups, seven each group for design. control ischemia reperfusion induced groups designated two while other four (TR1 TR4 ) administered varying doses at 0.5 mg/kg, 1 1.5 2 mg/kg group. After 60 min ischemic period, 24-hour period was implemented assess outcomes treatment IR. Histopathological analysis performed conjunction determination malondialdehyde (MDA) levels. In addition, serum concentrations adropin, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), well nitric oxide synthase (eNOS) measured order further define biochemical reactions treatment. MDA levels significantly elevated IR compared group, activities eNOS, SOD, GSH-Px enzymes decreased (P < 0.05). lower than those whereas higher Statistically, lowest observed highest noted examination revealed reduction tissue damage histological findings from this indicate provides dose-dependent manner.

Language: Английский

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Adropin Is Expressed in Pancreatic Islet Cells and Reduces Glucagon Release in Diabetes Mellitus

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 9824 - 9824

Published: Sept. 11, 2024

Diabetes mellitus affects 537 million adults around the world. Adropin is expressed in different cell types. Our aim was to investigate cellular localization endocrine pancreas and its effect on modulating pancreatic hormone release streptozotocin (STZ)-induced diabetic rats. expression investigated normal rats using immunohistochemistry immunoelectron microscopy. Serum levels of insulin, glucagon polypeptide (PP), somatostatin were measured a Luminex® χMAP (Magpix®) analyzer. Pancreatic INS-1 832/3 rat insulinoma cells, as well tissue fragments treated with concentrations adropin (10−6, 10−9, 10−12 M), ELISA. colocalized cells producing either glucagon, or PP. treatment reduced number glucagon-secreting alpha suppressed from pancreas. The serum GLP-1 amylin significantly increased after adropin. study indicates potential role secretion animal models diabetes mellitus.

Language: Английский

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Predictors for Irreversibility of Contrast-Induced Acute Kidney Injury in Patients with Obesity After Contrast-Enhanced Computed Tomography Coronary Angiography

Advances in Therapy, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 11, 2024

Language: Английский

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Adropin a candidate diagnostic biomarker for cardiovascular disease in patients with chronic kidney disease

Journal of Genetic Engineering and Biotechnology, Journal Year: 2024, Volume and Issue: 22(4), P. 100438 - 100438

Published: Nov. 20, 2024

Chronic kidney disease (CKD) is a chief worldwide health concern that has substantial financial impact on systems, high rates of mortality and morbidity as well cardiovascular (CVD) major cause in this population. Adropin unique hormone encoded by the energy homeostasis-associated (Enho) gene.

Language: Английский

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