The impact of metabolic reprogramming on tertiary lymphoid structure formation: enhancing cancer immunotherapy DOI Creative Commons

Meng-Jie Zhang,

Yan Wen, Zhi‐Jun Sun

et al.

BMC Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 13, 2025

Cancer immunotherapy has achieved unprecedented success in the field of cancer therapy. However, its potential is constrained by a low therapeutic response rate. Tertiary lymphoid structure (TLS) plays crucial role antitumor immunity and associated with good prognosis. Metabolic reprogramming, as hallmark tumor microenvironment, can influence promote formation follicular helper T cells germinal centers. many current studies focus on correlation between metabolism TLS factors, there insufficient direct evidence to suggest that drives formation. This review provided comprehensive summary relationship formation, highlighting glucose metabolism, lipid amino acid vitamin metabolism. In future, an in-depth exploration how affects cell interactions microorganisms will significantly advance our understanding metabolism-enhanced immunity.

Language: Английский

Novel hormone therapies for advanced prostate cancer: understanding and countering drug resistance DOI Creative Commons
Zhipeng Wang, Jie Wang,

Dengxiong Li

et al.

Journal of Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 101232 - 101232

Published: Feb. 1, 2025

Language: Английский

Citations

1
Cancer and the Microbiome of the Human Body DOI Open Access
Lourdes Herrera‐Quintana, Héctor Vázquez‐Lorente, María López-Garzón

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(16), P. 2790 - 2790

Published: Aug. 21, 2024

Cancer remains a public health concern worldwide, with its incidence increasing worldwide and expected to continue growing during the next decades. The microbiome has emerged as central factor in human disease, demonstrating an intricate relationship between cancer. Although some microbiomes present within local tissues have been shown restrict cancer development, mainly by interacting cells or host immune system, microorganisms are harmful risk factors for development. This review summarizes recent evidence concerning of most common types (i.e., lung, head neck, breast, gastric, colorectal, prostate, cervix cancers), providing general overview future clinical approaches perspectives.

Language: Английский

Citations

4
Microbiome-mediated immune modulation in tumor microenvironment DOI
John O. Richards,

Eleanor L. Davis,

L. Shakila

et al.

International review of cell and molecular biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Gut microbial metabolites as a convergence point between autoimmunity and solid tumors DOI Creative Commons

Anu Shibi Anilkumar,

Sheena Mariam Thomas, Ramakrishnan Veerabathiran

et al.

Gut Microbes Reports, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12

Published: March 12, 2025

Language: Английский

Citations

0
Revealing gut microbiota biomarkers associated with melanoma immunotherapy response and key bacteria-fungi interaction relationships: evidence from metagenomics, machine learning, and SHAP methodology DOI Creative Commons
Yuhang Zhou, Wenjie Han,

Yun Feng

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 18, 2025

The gut microbiota is associated with the response to immunotherapy in cutaneous melanoma (CM). However, fungal biomarkers and bacterial-fungal interactions have yet be determined. Metagenomic sequencing data of stool samples collected before from three independent groups European ancestry CM patients were collected. After characterizing relative abundances bacteria fungi, Linear Discriminant Analysis Effect Size (LEfSe) analysis, Random Forest (RF) model construction, SHapley Additive exPlanations (SHAP) methodology applied identify key responders CM. Diversity analysis revealed significant differences bacterial composition between non-responders. LEfSe identified 45 4 taxa as potential biomarkers. constructing RF model, AUC models built using separately 0.64 0.65, respectively. when combined, merged increased 0.71. In following important biomarkers: Romboutsia, Endomicrobium, Aggregatilinea, Candidatus Moduliflexus, Colwellia, Akkermansia, Mucispirillum, Rutstroemia, which responders, whereas Zancudomyces was Moreover, positive correlation interaction Akkermansia Rutstroemia considered a response. Our results provide valuable insights for enrichment patients. this study highlights critical role immunotherapy.

Language: Английский

Citations

0
The impact of metabolic reprogramming on tertiary lymphoid structure formation: enhancing cancer immunotherapy DOI Creative Commons

Meng-Jie Zhang,

Yan Wen, Zhi‐Jun Sun

et al.

BMC Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 13, 2025

Cancer immunotherapy has achieved unprecedented success in the field of cancer therapy. However, its potential is constrained by a low therapeutic response rate. Tertiary lymphoid structure (TLS) plays crucial role antitumor immunity and associated with good prognosis. Metabolic reprogramming, as hallmark tumor microenvironment, can influence promote formation follicular helper T cells germinal centers. many current studies focus on correlation between metabolism TLS factors, there insufficient direct evidence to suggest that drives formation. This review provided comprehensive summary relationship formation, highlighting glucose metabolism, lipid amino acid vitamin metabolism. In future, an in-depth exploration how affects cell interactions microorganisms will significantly advance our understanding metabolism-enhanced immunity.

Language: Английский

Citations

0