Role of MicroRNAs in Acute Myeloid Leukemia DOI Open Access
Aneta Wiśnik, Dariusz Jarych, Kinga Krawiec

et al.

Genes, Journal Year: 2025, Volume and Issue: 16(4), P. 446 - 446

Published: April 11, 2025

MicroRNA (miRNA), a significant class of regulatory non-coding RNA (ncRNA), can regulate the expression numerous protein-coding messenger RNAs (mRNAs). miRNA plays an important part in shaping human transcriptome. So far, genome, about 2500 miRNAs have been found. Acute myeloid leukemia (AML) belongs to malignant clonal disorder hematopoietic stem cells and is characterized by uncontrolled proliferation abnormal progenitor bone marrow blood. For past several years, scientific attention has attracted role AML, since alterations levels may contribute AML development. This review describes main functions classes presents biogenesis. study aims recent reports altered microRNA their influence on cell survival, cycle, apoptotic potential. Additionally, it summarizes correlations between target mRNAs outlines particular subtypes according ELN recommendations.

Language: Английский

Frequent Dysregulation of Multiple Circular RNA Isoforms with Diverse Regulatory Mechanisms in Cancer — Insights from CircFNDC3B and Beyond: Why Unique Circular RNA Identifiers Matter DOI

Chiu-Jung Huang,

Kong‐Bung Choo

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: 758, P. 151627 - 151627

Published: March 13, 2025

Language: Английский

Citations

0
Role of MicroRNAs in Acute Myeloid Leukemia DOI Open Access
Aneta Wiśnik, Dariusz Jarych, Kinga Krawiec

et al.

Genes, Journal Year: 2025, Volume and Issue: 16(4), P. 446 - 446

Published: April 11, 2025

MicroRNA (miRNA), a significant class of regulatory non-coding RNA (ncRNA), can regulate the expression numerous protein-coding messenger RNAs (mRNAs). miRNA plays an important part in shaping human transcriptome. So far, genome, about 2500 miRNAs have been found. Acute myeloid leukemia (AML) belongs to malignant clonal disorder hematopoietic stem cells and is characterized by uncontrolled proliferation abnormal progenitor bone marrow blood. For past several years, scientific attention has attracted role AML, since alterations levels may contribute AML development. This review describes main functions classes presents biogenesis. study aims recent reports altered microRNA their influence on cell survival, cycle, apoptotic potential. Additionally, it summarizes correlations between target mRNAs outlines particular subtypes according ELN recommendations.

Language: Английский

Citations

0