Determination of antibacterial activity of resveratrol on some pathogenic bacteria DOI

Nihal Mısır,

Serpil Uğraş

Bulletin of Biotechnology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

This study aims to investigate the antibacterial effect of resveratrol, a natural polyphenol, on some pathogenic bacteria. Resveratrol is compound found in plants such as red grapes and known for its antioxidant, anti-inflammatory antimicrobial properties. Due these properties, it considered potential agent prevention treatment bacterial infections. In this context, study, was aimed determine effects effective dosage resveratrol Salmonella typhimurium, Staphylococcus epidermidis, Pseudomanas aeruginosa, Yersinia pseudotuberculosis, Proteus vulgaris, Enterococcus faecalis, Enterobacter cloaceae, Escherichia coli, Listeria monocytogenes. Antibacterial activity studies were performed by agar well diffusion method. As result studies, inhibition zones with diameter 14.0 ± 1.0 mm S. 15.0 0.5 E. cloaceae 16.0 L. monocytogenes measured at 500 µg\mL resveratrol. However, have bacteriostatic against P. Y. vulgaris coli. According results, can be said that may bacteria contribute development new strategies use an antibiotic adjuvant, although terms both food safety public health foreseen.

Language: Английский

Natural products in the treatment of diabetic foot infection DOI Creative Commons
Mohsen Nazari, Leili Shokoohizadeh, Mohammad Taheri‬

et al.

European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)

Published: Jan. 7, 2025

Diabetic foot infections (DFIs) are a significant complication in diabetes mellitus, leading to increased morbidity, hospitalizations, and healthcare burdens. The growing prevalence of antibiotic-resistant pathogens has reduced the efficacy conventional treatments, highlighting need for alternative therapeutic strategies. Natural products, known their antimicrobial, anti-inflammatory, wound-healing properties, have garnered attention as potential treatments DFIs. This review examines key natural compounds, including eugenol, thymol, carvacrol, curcumin, Aloe vera, mechanisms action combating diabetic infections. We analyze antimicrobial these ability inhibit biofilm formation, role wound healing. also explores challenges integrating products into clinical practice use alongside or place traditional antibiotic therapies. Our findings suggest that could play crucial developing sustainable effective treatment strategies DFIs, especially face rising resistance.

Language: Английский

Citations

2
Characteristics of Resveratrol Tablets Stored Under Stress Conditions by Total Hemispherical Reflectance and Selected Pharmacopoeial Parameters DOI Open Access
Beata Szulc-Musioł, Beata Sarecka‐Hujar

Processes, Journal Year: 2025, Volume and Issue: 13(3), P. 638 - 638

Published: Feb. 24, 2025

The introduction of medicine into the pharmaceutical market must be preceded by a stability study. One most important reasons for instability drug preparation is improper storage patient, which can accelerate degradation process. In this study, novel directional-hemispherical reflectance (THR) and traditional (hardness friability) methods quality control were used in characteristics resveratrol supplemental tablets exposed to light elevated temperatures. stored an aging chamber at two different temperatures (25 °C, 45 °C) over time intervals (1 h, 3 1 day, 5 days), yielding seven conditions. 410-Solar Reflectometer allowed us determine THR values spectral ranges: 335–380, 400–540, 480–600, 590–720, 700–1100, 1000–1700, 1700–2500 nm. At each point, stress conditions characterized lower all ranges, compared on day 0. Compared 0, significant differences observed 25 °C temperature across entire spectrum studied. change experiment was significantly higher only UVA 335–380 nm range. addition, changes strength parameters tablets, i.e., increase hardness decrease friability found days irrespective temperature. Such after UV heat exposure are probably due homogeneity tablet matrix may indicate possible physical chemical occurring surface or inside tablet.

Language: Английский

Citations

0
Medicinal plants: bioactive compounds, biological activities, combating multidrug-resistant microorganisms, and human health benefits - a comprehensive review DOI Creative Commons
Mohamed T. El‐Saadony, Ahmed M. Saad, Dina Mostafa Mohammed

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 28, 2025

In recent years, medicinal plants have gained significant attention in modern medicine due to their accessibility, affordability, widespread acceptance, and safety, making herbal remedies highly valued globally. Consequently, ensuring plants’ quality, efficacy, safety has become a critical concern for developed developing nations. The emergence of multidrug-resistant microorganisms poses serious global health threat, particularly low-income regions, despite advancements antimicrobial drugs medical research over the past century. rapid spread these infections is primarily attributed improper prescriptions, overuse, unregulated access antibiotics. Addressing challenges, standardization plant-derived pharmaceuticals could pave way transformative era healthcare. Preserving leveraging historical knowledge essential before such valuable information lost. Recently, there been growing interest among natural pharmaceutical scientists exploring as potential sources agents. This current review aims identify most common pathogens threatening human health, analyze factors contributing rise drug-resistant microorganisms, evaluate use across various countries alternative antibiotics, highlighting unique mechanisms resistance.

Language: Английский

Citations

0
Resveratrol inhibits the formation of Staphylococcus aureus biofilms by reducing PIA, eDNA release, and ROS production DOI Creative Commons
Jianming He, Yang Cui, Yan Liu

et al.

Frontiers in Veterinary Science, Journal Year: 2025, Volume and Issue: 12

Published: April 30, 2025

Staphylococcus aureus is a zoonotic pathogen that difficult to control. Resveratrol (RES) has been shown have significant antibacterial effects. The present study aimed investigate the inhibitory effect of RES on formation biofilms and their molecular mechanism. First, minimum concentration action curve against were obtained through testing. Second, we found can inhibit biofilm by reducing release polysaccharide intercellular adhesion (PIA) extracellular DNA (eDNA) from aureus. treatment significantly reduced production reactive oxygen species (ROS) nicotinamide adenine dinucleotide phosphate (NADPH) in aureus, indicating ROS NADPH are closely related formation. This demonstrates inhibits PIA, eDNA release, production, these results provide new ideas for clinical application infection.

Language: Английский

Citations

0
Determination of antibacterial activity of resveratrol on some pathogenic bacteria DOI

Nihal Mısır,

Serpil Uğraş

Bulletin of Biotechnology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

This study aims to investigate the antibacterial effect of resveratrol, a natural polyphenol, on some pathogenic bacteria. Resveratrol is compound found in plants such as red grapes and known for its antioxidant, anti-inflammatory antimicrobial properties. Due these properties, it considered potential agent prevention treatment bacterial infections. In this context, study, was aimed determine effects effective dosage resveratrol Salmonella typhimurium, Staphylococcus epidermidis, Pseudomanas aeruginosa, Yersinia pseudotuberculosis, Proteus vulgaris, Enterococcus faecalis, Enterobacter cloaceae, Escherichia coli, Listeria monocytogenes. Antibacterial activity studies were performed by agar well diffusion method. As result studies, inhibition zones with diameter 14.0 ± 1.0 mm S. 15.0 0.5 E. cloaceae 16.0 L. monocytogenes measured at 500 µg\mL resveratrol. However, have bacteriostatic against P. Y. vulgaris coli. According results, can be said that may bacteria contribute development new strategies use an antibiotic adjuvant, although terms both food safety public health foreseen.

Language: Английский

Citations

0