Echinacoside Prevents Sepsis-Induced Myocardial Damage via Targeting SOD2 DOI
Xin Li, Zuojing Zhang, Xiaoxuan Zhang

et al.

Journal of Medicinal Food, Journal Year: 2023, Volume and Issue: 27(2), P. 123 - 133

Published: Dec. 15, 2023

Echinacoside (ECH) is a prominent naturally occurring bioactive compound with effects of alleviating myocardial damage. We aimed to explore the beneficial ECH against sepsis-induced damage and elucidate potential mechanism. Echocardiography Masson staining demonstrated that alleviates cardiac function fibrosis in cecal ligation puncture (CLP) model. Transcriptome profiling network pharmacology analysis showed there are 51 overlapping targets between ECH. Subsequently, chemical carcinogenesis-reactive oxygen species (ROS) were enriched multiple targets. Wherein, SOD2 may be target on Polymerase chain reaction results administration could markedly increase expression reduce release ROS. Combined injecting inhibitor SOD2, effect mortality, function, was eliminated, ROS increased after inhibiting SOD2. significantly alleviated septic mice, therapeutic mechanism achieved by upregulating which decreased

Language: Английский

Practical Lessons on Antimicrobial Therapy for Critically Ill Patients DOI Creative Commons
Rachael Cusack, Elizabeth Little, Ignacio Martín‐Loeches

et al.

Antibiotics, Journal Year: 2024, Volume and Issue: 13(2), P. 162 - 162

Published: Feb. 6, 2024

Sepsis stands as a formidable global health challenge, with persistently elevated mortality rates in recent decades. Each year, sepsis not only contributes to heightened morbidity but also imposes substantial healthcare costs on survivors. This narrative review aims highlight the targeted measures that can be instituted alleviate incidence and impact of intensive care. Here we discuss reduce nosocomial infections prevention equipment patient colonisation by resilient pathogens. The overarching crisis bacterial resistance newly developed antimicrobial agents intensifies imperative for stewardship de-escalation. urgency has been accentuated years, notably during COVID-19 pandemic, high-dose steroids opportunistic presented escalating challenges. Ongoing research into airway colonisation’s role influencing disease outcomes among critically ill patients underscores importance tailoring treatments endotypes within heterogeneous populations, which are important lessons intensivists training. Looking ahead, significance novel delivery systems drug monitoring is poised increase. delves multifaceted barriers facilitators inherent effectively treating vulnerable infections. future trajectory care medicine hinges meticulous implementation vigilant programs, robust infection control measures, continued exploration innovative efficient technological solutions this demanding landscape.

Language: Английский

Citations

8
A murine model of acute and prolonged abdominal sepsis, supported by intensive care, reveals time-dependent metabolic alterations in the heart DOI Creative Commons
Bart Jacobs,

Inge Derese,

Sarah Derde

et al.

Intensive Care Medicine Experimental, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 17, 2025

Abstract Background Sepsis-induced cardiomyopathy (SICM) often occurs in the acute phase of sepsis and is associated with increased mortality due to cardiac dysfunction. The pathogenesis remains poorly understood, no specific treatments are available. Although SICM considered reversible, emerging evidence suggests potential long-term sequelae. We hypothesized that metabolic inflammatory changes, previously observed as drivers SICM, partially persist prolonged sepsis. Methods In 24-week-old C57BL/6J mice, was induced by cecal ligation puncture, followed intravenous fluid resuscitation, subcutaneous analgesics antibiotics, and, phase, parenteral nutrition. Mice were killed after 5 days (prolonged sepsis, n = 15). For comparison, we included acutely septic mice at 30 h (acute 15) healthy controls animals (HC, Cardiac tissue collected for assessment markers through gene expression, metabolomic analysis histological assessment. Results expression IL-1β IL-6 macrophage infiltration remained upregulated ( p ≤ 0.05). contrast, levels Krebs cycle intermediates adenosine phosphates normal, whereas NADPH low Gene fatty acid transporters glucose transporter Slc2a1 0.01). Lipid staining glycogen content elevated together enzymes responsible lipogenesis synthesis Intermediate glycolytic metabolites (hexose-phosphates, GADP, DHAP) 0.05), but several glycolysis mitochondrial oxidation pyruvate, fatty-acyl-CoA ketone bodies acetyl-CoA suppressed Key transcription factors PPARα PGC-1α downregulated acute, prolonged, 0.05 both). Ketone body concentrations normal ketolytic Amino metabolism showed mild, mixed changes. Conclusions Our results suggest myocardial lipid accumulation oxidation, a functionally intact cycle, ongoing inflammation. Whether these alterations have functional consequences predispose sequelae needs further research.

Language: Английский

Citations

0
Melatonin-Mediated Protection against Sepsis-Induced Organ Dysfunction DOI
Hilal Üstündağ, Songül Doğanay

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Sepsis-induced organ dysfunction represents a critical challenge in intensive care medicine, characterized by complex pathophysiological mechanisms that can lead to multiple failure and death. This review examines the fundamental underlying sepsis-induced explores therapeutic potential of melatonin, multifaceted molecule with potent antioxidant anti-inflammatory properties. We analyzed pathways involved damage during sepsis, including inflammatory cascades, oxidative stress, mitochondrial dysfunction, endothelial injury. Special attention is given melatonin’s protective effects on various systems, cardiac, pulmonary, renal, hepatic, central nervous system function sepsis. Recent evidence suggests ability modulate these pathways, combined its excellent safety profile, makes it promising agent sepsis management. Understanding applications may provide new strategies for improving outcomes septic patients.

Language: Английский

Citations

0
Wogonin attenuates septic cardiomyopathy by suppressing ALOX15-mediated ferroptosis DOI
Ye Hua, Lin Wu, Yanmei Liu

et al.

Acta Pharmacologica Sinica, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Language: Английский

Citations

0
Nrf2 mediated signaling axis in sepsis-induced cardiomyopathy: potential Pharmacological receptor DOI
Sumei Wang, Shasha He,

Xiao Hu

et al.

Inflammation Research, Journal Year: 2025, Volume and Issue: 74(1)

Published: April 29, 2025

Language: Английский

Citations

0
Oligo-peptide I-C-F-6 mitigates polymicrobial sepsis-induced cardiac dysfunction in mice DOI
Hongxiao Li, Guang Li, Yuan Gao

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177545 - 177545

Published: March 1, 2025

Language: Английский

Citations

0
Associations between triglyceride-glucose body mass index and all-cause mortality in ICU patients with sepsis and acute heart failure DOI Creative Commons
Heping Xu,

Jinyuan Xie,

Huan Niu

et al.

BMC Cardiovascular Disorders, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 9, 2025

Language: Английский

Citations

0
Mechanism of Shenfu injection in suppressing inflammation and preventing sepsis-induced apoptosis in murine cardiomyocytes based on network pharmacology and experimental validation DOI
Po Huang, Yuhong Guo,

Xiao Hu

et al.

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 322, P. 117599 - 117599

Published: Dec. 27, 2023

Language: Английский

Citations

9
Assessment of mitochondrial function and its prognostic role in sepsis: a literature review DOI Creative Commons
Wagner Luís Nedel, Nathan Ryzewski Strogulski,

Afonso Kopczynski

et al.

Intensive Care Medicine Experimental, Journal Year: 2024, Volume and Issue: 12(1)

Published: Nov. 25, 2024

Language: Английский

Citations

1
METTL14 Promotes Lipopolysaccharide-Induced Myocardial Damage via m6A-Dependent Stabilization of TRPM7 mRNA DOI Open Access

Xinzhu Wu,

Pan Huang,

Yanmin Xiao

et al.

International Heart Journal, Journal Year: 2024, Volume and Issue: 65(6), P. 1118 - 1127

Published: Nov. 29, 2024

Sepsis-induced myocardial injury (SIMI) is a vital pathological component of severe sepsis and septic shock. As prevalent internal mRNA modification in eukaryotic cells, N6-methyladenosine (m6A) implicated immune disorders. Methyltransferase-like 14 (METTL14), core subunit the methyltransferase complex that catalyzes messenger RNA m6A modification, involved regulation human cardiomyocyte cell line (AC16) injury. This study aimed to explore role mechanism METTL14 lipopolysaccharide (LPS) -induced injury.Cell viability apoptosis were analyzed via 3- (4,5-Dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide (MTT), flow cytometry, TdT-mediated dUTP nick-end labeling (TUNEL) assay. The Tumor necrosis factor alpha (TNF-α) Interleukin-1beta (IL-1β) levels Enzyme linked immunosorbent assay (ELISA). Caspase-3 activity, reactive oxygen species malondialdehyde level, glutathione level assessed using special kits. transient receptor potential melastatin 7 (TRPM7) determined Real-time quantitative polymerase chain reaction (RT-qPCR). Meanwhile, protein TRPM7, METTL14, phospho-p65 (p-p65), total p65 (p65), p-IκBα, IκBα (IκBα) examined western blot assay.LPS treatment repressed AC16 induced apoptosis, inflammatory response, oxidative stress, ferroptosis vitro. TRPM7 upregulated LPS-treated cells. At molecular could increase stability methylation. Moreover, deficiency abolish LPS-triggered regulation.METTL14 knockdown reversed LPS-caused damage mainly by regulating mRNA, providing novel therapeutic target for cardiomyopathy treatment.

Language: Английский

Citations

1