Echinacoside Prevents Sepsis-Induced Myocardial Damage via Targeting SOD2 DOI
Xin Li, Zuojing Zhang, Xiaoxuan Zhang

et al.

Journal of Medicinal Food, Journal Year: 2023, Volume and Issue: 27(2), P. 123 - 133

Published: Dec. 15, 2023

Echinacoside (ECH) is a prominent naturally occurring bioactive compound with effects of alleviating myocardial damage. We aimed to explore the beneficial ECH against sepsis-induced damage and elucidate potential mechanism. Echocardiography Masson staining demonstrated that alleviates cardiac function fibrosis in cecal ligation puncture (CLP) model. Transcriptome profiling network pharmacology analysis showed there are 51 overlapping targets between ECH. Subsequently, chemical carcinogenesis-reactive oxygen species (ROS) were enriched multiple targets. Wherein, SOD2 may be target on Polymerase chain reaction results administration could markedly increase expression reduce release ROS. Combined injecting inhibitor SOD2, effect mortality, function, was eliminated, ROS increased after inhibiting SOD2. significantly alleviated septic mice, therapeutic mechanism achieved by upregulating which decreased

Language: Английский

Assessment of mitochondrial function and its prognostic role in sepsis: a literature review DOI Creative Commons
Wagner Luís Nedel, Nathan Ryzewski Strogulski,

Afonso Kopczynski

et al.

Intensive Care Medicine Experimental, Journal Year: 2024, Volume and Issue: 12(1)

Published: Nov. 25, 2024

Language: Английский

Citations

1
METTL14 Promotes Lipopolysaccharide-Induced Myocardial Damage via m6A-Dependent Stabilization of TRPM7 mRNA DOI Open Access

Xinzhu Wu,

Pan Huang,

Yanmin Xiao

et al.

International Heart Journal, Journal Year: 2024, Volume and Issue: 65(6), P. 1118 - 1127

Published: Nov. 29, 2024

Sepsis-induced myocardial injury (SIMI) is a vital pathological component of severe sepsis and septic shock. As prevalent internal mRNA modification in eukaryotic cells, N6-methyladenosine (m6A) implicated immune disorders. Methyltransferase-like 14 (METTL14), core subunit the methyltransferase complex that catalyzes messenger RNA m6A modification, involved regulation human cardiomyocyte cell line (AC16) injury. This study aimed to explore role mechanism METTL14 lipopolysaccharide (LPS) -induced injury.Cell viability apoptosis were analyzed via 3- (4,5-Dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide (MTT), flow cytometry, TdT-mediated dUTP nick-end labeling (TUNEL) assay. The Tumor necrosis factor alpha (TNF-α) Interleukin-1beta (IL-1β) levels Enzyme linked immunosorbent assay (ELISA). Caspase-3 activity, reactive oxygen species malondialdehyde level, glutathione level assessed using special kits. transient receptor potential melastatin 7 (TRPM7) determined Real-time quantitative polymerase chain reaction (RT-qPCR). Meanwhile, protein TRPM7, METTL14, phospho-p65 (p-p65), total p65 (p65), p-IκBα, IκBα (IκBα) examined western blot assay.LPS treatment repressed AC16 induced apoptosis, inflammatory response, oxidative stress, ferroptosis vitro. TRPM7 upregulated LPS-treated cells. At molecular could increase stability methylation. Moreover, deficiency abolish LPS-triggered regulation.METTL14 knockdown reversed LPS-caused damage mainly by regulating mRNA, providing novel therapeutic target for cardiomyopathy treatment.

Language: Английский

Citations

1
Nadir ancak ölümcül bir enfeksiyon üzerine karşılaştırmalı bir çalışma: Post-sternotomi mediastinit ve descending nekrotizan mediastinitte sonucu belirleyici faktörlerin analizi DOI Open Access
Tülay Ünver Ulusoy, Hanife Nur Karakoç, Yunus Gürbüz

et al.

Turkish Journal of Clinics and Laboratory, Journal Year: 2024, Volume and Issue: 15(1), P. 8 - 15

Published: March 12, 2024

Amaç: Mediastinit; nadir görülen ciddi bir enfeksiyondur. Bu çalışmanın amacı, post-sternotomi mediastinit (PSM) veya descending nekrotizan (DNM) tanısı alan hastaların demografik, klinik ve laboratuvar özelliklerini karşılaştırmak mortalite belirlemektir. Gereç Yöntemler: çalışmaya 2015-2022 yılları arasında Sağlık Bilimleri Üniversitesi Dışkapı Yıldırım Beyazıt Eğitim Araştırma Hastanesi'nde PSM DNM hastalar dahil edilmiştir. Hastalar hayatta kalanlar kalamayanlar olarak kategorize edilmiştir karşılaştırılmıştır. Bulgular: konulan 25 hasta Ortalama yaş 54.9 ± 12.1 olup, %64'ü erkekti. Hastaların %92'sinden kan kültürü alınmıştır. %88'inden pürülan akıntı kültürleri gönderilmiştir, %44'ünde üreme tespit %84'ünde komorbidite mevcuttur varlığı, sepsis varlığı tanı sonrası yoğunbakım ünitesinde (YBÜ) yatış günü prevalansı hastalarında anlamlı daha yüksekti (p=0.017, p=0.004, p=0.026). Kalp yetmezliği, koroner arter hastalığı (KAH) hipertansiyon (HT) (ps=0.000). hastaları; kalamayan grupta da yaygındı (p=0.012). Hayatta ortalaması yüksek, sigara içenlerin sayısı fazla YBÜ'de kalma süresi uzundu (p=0,046, p=0,049, p=0,038). PSM, HT KAH olan (p=0.012, p=0.008, p=0.033). Sonuç: ancak yüksek morbidite oranlarına sahip Yaşlılar, içenler, median sternotomi yapılanlar komorbiditeleri olanlar gibi riski hastalarda tedavi takip stratejileri geliştirilebilir.

Citations

0
Doble estrés cardiaco en el periodo postparto. Reporte de un caso de cardiomiopatía inducida por sepsis complicada con embolismo pulmonar agudo DOI

Andrea Estrada-Méndez,

César René Alducín-Téllez,

Domingo José Gómez-Alayola

et al.

Cardiovascular and Metabolic Science, Journal Year: 2024, Volume and Issue: 35(2), P. 54 - 64

Published: Jan. 1, 2024

Citations

0
Nppb contributes to Sepsis-Induced myocardial injury by regulating Senescence-Related genes DOI
Hang Yang,

Zhenjie Jiang,

Feng Lin

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 143, P. 113461 - 113461

Published: Oct. 23, 2024

Language: Английский

Citations

0
Metoprolol use is associated with improved outcomes in patients with sepsis-induced cardiomyopathy: an analysis of the MIMIC-IV database DOI Creative Commons
Liping Zhong, Yuting Zhong,

Yilin Liao

et al.

BMC Cardiovascular Disorders, Journal Year: 2024, Volume and Issue: 24(1)

Published: Oct. 24, 2024

Metoprolol is commonly administered to critically ill patients; however, its effect on mortality in patients with sepsis-induced cardiomyopathy (SICM) remains uncertain. This study aimed investigate the relationship between metoprolol use and SICM.

Language: Английский

Citations

0
A mechanism study of tripartite motif 10 modulating septic cardiomyopathy DOI Open Access
Zhimei Yang, Jie Su

CytoJournal, Journal Year: 2024, Volume and Issue: 21, P. 73 - 73

Published: Dec. 26, 2024

Septic cardiomyopathy (SCM), as a complication of the septic process, severely affects myocardial function patients, but its pathogenesis remains unclear. The article aims to explore mechanism tripartite motif 10 (TRIM10) in rats with SCM and provide animal experimental basis for treatment prevention SCM. An rat model was constructed by intraperitoneal injection lipopolysaccharide (LPS). Sh-NC sh-TRIM10 groups were injected sh-NC tail vein 3 consecutive days before modeling. expression TRIM10 detected Western blot reverse transcription-polymerase chain reaction analyses. Hematoxylin-eosin staining performed observe pathological changes myocardium. Cardiomyocyte apoptosis flow cytometry. Serum levels cardiac troponin I, myohemoglobin, creatine kinase-MB, interleukin-18 (IL-18), interleukin-1 β (IL-1β), tumor necrosis factor-α (TNF-α), superoxide dismutase, glutathione peroxidase (GSH-Px) enzyme-linked immunosorbent assay. Apoptosis-related proteins toll-like receptor 4 (TLR4)/nuclear transcription factor-κB (NF-κB) pathway-related explored increased LPS group (P < 0.0001). Myocardial tissue injury improved after reduction compared that group. Knockdown decreased MDA 0.01), IL-18 0.0001), IL-1β TNF-α 0.0001) contents SOD 0.001) GSH-Px those reduced H9C2 cells After interference, p-P65/P65 TLR4 decreased. knockdown can reduce inflammation, oxidative stress, has protective effect on cardiomyocytes, which may be attributed regulation TLR4/NF-κB pathway.

Language: Английский

Citations

0
Echinacoside Prevents Sepsis-Induced Myocardial Damage via Targeting SOD2 DOI
Xin Li, Zuojing Zhang, Xiaoxuan Zhang

et al.

Journal of Medicinal Food, Journal Year: 2023, Volume and Issue: 27(2), P. 123 - 133

Published: Dec. 15, 2023

Echinacoside (ECH) is a prominent naturally occurring bioactive compound with effects of alleviating myocardial damage. We aimed to explore the beneficial ECH against sepsis-induced damage and elucidate potential mechanism. Echocardiography Masson staining demonstrated that alleviates cardiac function fibrosis in cecal ligation puncture (CLP) model. Transcriptome profiling network pharmacology analysis showed there are 51 overlapping targets between ECH. Subsequently, chemical carcinogenesis-reactive oxygen species (ROS) were enriched multiple targets. Wherein, SOD2 may be target on Polymerase chain reaction results administration could markedly increase expression reduce release ROS. Combined injecting inhibitor SOD2, effect mortality, function, was eliminated, ROS increased after inhibiting SOD2. significantly alleviated septic mice, therapeutic mechanism achieved by upregulating which decreased

Language: Английский

Citations

0