Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 263, P. 155619 - 155619
Published: Sept. 28, 2024
Language: Английский
Molecular Carcinogenesis, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 21, 2025
ABSTRACT Esophageal squamous cell carcinoma (ESCC) is prone to metastasis and a leading cause of mortality. The cytoskeleton closely related morphology movement; however, little research has been conducted on ESCC metastasis. In this study, we found that the anchoring filament protein ladinin 1 (LAD1) specifically binds LINC01305 for co‐regulating level modulating cortactin proteins (CTTN) neuronal Wiskott–Aldrich syndrome (N‐WASP) phosphorylation, which mediates cytoskeletal reorganization affects cells. Additionally, LAD1 jointly promoted epithelial–mesenchymal transition (EMT) process by activating phosphoinositide‐3‐kinase–protein kinase B (PI3K/AKT) signaling pathway. Moreover, were late clinical stage lymph node ESCC. Our study demonstrated are major determinants dissemination revealed novel molecular mechanism controls Trial Registration: N/A.
Language: Английский
Citations
0
Clinica Chimica Acta, Journal Year: 2025, Volume and Issue: unknown, P. 120242 - 120242
Published: March 1, 2025
Language: Английский
Citations
0
Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)
Published: April 28, 2025
Esophageal cancer (EC) is the sixth most common cause of cancer-related deaths globally. Genetic and environmental factors could be affected in EC's onset development. The potential involvement lncRNA-HOTAIR lncRNA-MALAT1 EC has garnered significant attention recent studies. Our investigation aimed to examine gene expression changes patients. experimental study focused on 140 patients with malignant EC, comprising 70 paraffin-embedded tumor tissues (FFPE) blocks FFPE marginal tissue samples. relative levels were measured using Real-Time PCR. data analyzed ANOVA 2-△△CT tests. analysis revealed a increase compared (P < 0.05). Besides, our research correlation between hot drinks = 0.019), metastasis 0.001), 5-year survival rate 0.001). We found alcohol abuse 0.039), 0.039). findings indicate carcinogenic effect alterations Also, studying lncRNA genes can help us identify biomarkers, emphasizing significance early diagnosis treatment.
Language: Английский
Citations
0
Journal of Thoracic Disease, Journal Year: 2024, Volume and Issue: 16(12), P. 8754 - 8770
Published: Dec. 1, 2024
Tyrosine kinase inhibitors (TKIs) are the first-line therapy for patients with non-small cell lung cancer (NSCLC) sensitized mutations in epidermal growth factor receptor (EGFR). However, resistance to TKIs is a major clinical issue that affects survival and prognosis of patients, mechanisms underlying this remaining elusive. Circular RNAs (circRNAs) class single-stranded, covalently closed RNA molecules, which generated from pre-messenger (mRNAs) through back splicing. The aim study was investigate role cRNA SPECC1 promoting NSCLC explore its potential involvement tumorigenesis metastasis adenocarcinoma (LUAD). In study, we identified differentially expressed genes sequencing three tumor samples obtained poor postoperative TKI treatment outcomes. Validation performed using quantitative real-time polymerase chain reaction (qRT-PCR) function experiments. We further constructed competing endogenous (ceRNA) network Gene Ontology (GO) analysis circRNA. circular (circSPECC1) found be significantly upregulated tumors as compared adjacent tissues. Knockdown circSPECC1 lines resulted decreased proliferation, migration, invasion. Additionally, apoptosis increased TKI-sensitive EGFR when treated osimertinib. may promote contribute NSCLC. This offers novel perspective on research at level.
Language: Английский
Citations
1
Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 263, P. 155619 - 155619
Published: Sept. 28, 2024
Language: Английский
Citations
0