Detecting PI3K and TP53 Pathway Disruptions in Early-Onset Colorectal Cancer Among Hispanic/Latino Patients DOI Creative Commons
Cecilia Monge, Brigette Waldrup, Sophia Manjarrez

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 13, 2024

Abstract Background/Objectives This study aims to characterize PI3K and TP53 pathway alterations in Hispanic/Latino patients with early-onset colorectal cancer (CRC), focusing on potential differences compared non-Hispanic White (NHW) patients. Understanding these may shed light the molecular basis of CRC health disparities. Methods Using cBioPortal, we conducted a bioinformatics analysis evaluate mutations within pathways. cases were stratified by age ethnicity: (1) (<50 years) versus late-onset (≥50 (2) NHW Mutation frequencies assessed using descriptive statistics, chi-squared tests comparing proportions between groups. Kaplan- Meier survival curves generated assess overall for patients, presence or absence alterations. Results Significant noted when more prevalent among (90.5% vs. 41.5%, p = 9.279e-5), mTOR also significantly higher this group (14.3% 1.5%, 0.043). No significant observed early- onset cohort. Additionally, showed improved clinical outcomes present (p =5.4e-4). Conclusions These findings highlight distinct role disruptions suggesting that pathway-specific mechanisms drive Insights from could inform development precision medicine approaches targeted therapies aimed at addressing disparities improving diverse patient populations.

Language: Английский

T cell aging and exhaustion: Mechanisms and clinical implications DOI
Weiqi Zhang, Dejun Kong,

Xiaohan Zhang

et al.

Clinical Immunology, Journal Year: 2025, Volume and Issue: 275, P. 110486 - 110486

Published: March 20, 2025

Language: Английский

Citations

0
Molecular Alterations in TP53, WNT, PI3K, TGF-Beta, and RTK/RAS Pathways in Gastric Cancer Among Ethnically Heterogeneous Cohorts DOI Open Access
Cecilia Monge,

Brigette Waldrup,

Francisco Carranza

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(7), P. 1075 - 1075

Published: March 23, 2025

Gastric cancer (GC) remains a leading cause of cancer-related mortality worldwide, with significant racial and ethnic disparities in incidence, molecular characteristics, patient outcomes. However, genomic studies focusing on Hispanic/Latino (H/L) populations remain scarce, limiting our understanding ethnicity-specific alterations. This study aims to characterize pathway-specific mutations TP53, WNT, PI3K, TGF-Beta, RTK/RAS signaling pathways GC compare mutation frequencies between H/L Non-Hispanic White (NHW) patients. Additionally, we evaluate the impact these alterations overall survival using publicly available datasets. We conducted bioinformatics analysis datasets assess pathway genes. A total 800 patients were included analysis, comprising 83 717 NHW Patients stratified by ethnicity (H/L vs. NHW) differences prevalence. Chi-squared tests performed rates groups Kaplan-Meier was used based among both Significant observed TP53 related genes when comparing less prevalent (9.6% 19%, p = 0.03). Borderline noted WNT patients, more frequent (8.4% 4%, 0.08) APC being significantly higher (3.6% 0.8%, 0.05). Although not statistically significant, borderline significance pathways, including EGFR (p 0.07), FGFR1 0.05), FGFR2 PTPN11 0.05) PI3K SMAD4 TGF-Beta pathway. Survival revealed no exhibited survival, while those without also showed impact. In contrast, associated differences. These findings suggest that disruptions may have distinct prognostic implications provides one first ethnicity-focused analyses GC, revealing racial/ethnic dysregulation. The play critical role greater insights emphasize need for precision medicine approaches account genetic heterogeneity improve care outcomes underrepresented populations.

Language: Английский

Citations

0
Detecting PI3K and TP53 Pathway Disruptions in Early‐Onset Colorectal Cancer Among Hispanic/Latino Patients DOI Creative Commons
Cecilia Monge,

Brigette Waldrup,

Sophia Manjarrez

et al.

Cancer Medicine, Journal Year: 2025, Volume and Issue: 14(7)

Published: April 1, 2025

ABSTRACT Background/Objectives This study aims to characterize PI3K and TP53 pathway alterations in Hispanic/Latino patients with early‐onset colorectal cancer (CRC), focusing on potential differences compared non‐Hispanic White patients. Understanding these may shed light the molecular basis of CRC health disparities. Methods Using cBioPortal, we conducted a bioinformatics analysis evaluate mutations within pathways. were stratified by age ethnicity: (1) (< 50 years) versus late‐onset (≥ (2) Mutation frequencies assessed using descriptive statistics, chi‐squared tests comparing proportions between groups. Kaplan–Meier survival curves generated assess overall for patients, presence or absence alterations. Results Significant noted when (47.1% vs. 35.2%, p = 9.39e‐3) (89.1% 81.7%, 0.04) more prevalent among AKT1 (5.1% 1.8%, 0.03), INPP4B (4.3% 1.4%, 0.04), TSC1 (7.2% 3.1% 0.03) gene also significantly higher this group. observed colon adenocarcinomas (90% 79.1%, prevalence tumor site. No significant cohort. Conclusions These findings highlight distinct role disruptions suggesting that pathway‐specific mechanisms drive Insights from could inform development precision medicine approaches targeted therapies aimed at addressing

Language: Английский

Citations

0
An antibody targeting an immune checkpoint molecule BTN2A2 enhances anti-tumor immunity DOI
Xiao Li,

Rong Hu,

Wei Chen

et al.

Neoplasia, Journal Year: 2025, Volume and Issue: 65, P. 101161 - 101161

Published: April 21, 2025

Language: Английский

Citations

0
Detecting PI3K and TP53 Pathway Disruptions in Early-Onset Colorectal Cancer Among Hispanic/Latino Patients DOI Creative Commons
Cecilia Monge, Brigette Waldrup, Sophia Manjarrez

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 13, 2024

Abstract Background/Objectives This study aims to characterize PI3K and TP53 pathway alterations in Hispanic/Latino patients with early-onset colorectal cancer (CRC), focusing on potential differences compared non-Hispanic White (NHW) patients. Understanding these may shed light the molecular basis of CRC health disparities. Methods Using cBioPortal, we conducted a bioinformatics analysis evaluate mutations within pathways. cases were stratified by age ethnicity: (1) (<50 years) versus late-onset (≥50 (2) NHW Mutation frequencies assessed using descriptive statistics, chi-squared tests comparing proportions between groups. Kaplan- Meier survival curves generated assess overall for patients, presence or absence alterations. Results Significant noted when more prevalent among (90.5% vs. 41.5%, p = 9.279e-5), mTOR also significantly higher this group (14.3% 1.5%, 0.043). No significant observed early- onset cohort. Additionally, showed improved clinical outcomes present (p =5.4e-4). Conclusions These findings highlight distinct role disruptions suggesting that pathway-specific mechanisms drive Insights from could inform development precision medicine approaches targeted therapies aimed at addressing disparities improving diverse patient populations.

Language: Английский

Citations

0