Genetic Predictors of Paxlovid Treatment Response: The Role of IFNAR2, OAS1, OAS3, and ACE2 in COVID-19 Clinical Course DOI Open Access
Mykhailo Buchynskyi, Iryna Kamyshna, Iryna Halabitska

et al.

Journal of Personalized Medicine, Journal Year: 2025, Volume and Issue: 15(4), P. 156 - 156

Published: April 17, 2025

Background: This study investigated the role of genetic polymorphisms in IFNAR2, OAS1, OAS3, and ACE2 as predictors Paxlovid treatment response, specifically examining their influence on clinical course laboratory parameters COVID-19 patients. Methods: We analyzed impact genes associated with interferon pathway (IFNAR2 rs2236757), antiviral response (OAS1 rs10774671, OAS3 rs10735079), viral entry (ACE2 rs2074192) individuals treated Paxlovid. Results: Our findings suggest that variations these may modulate immune coagulation pathways context during infection. Specifically, IFNAR2 rs2236757 G allele was alterations inflammatory markers, while OAS1 influenced parameters. Furthermore, specific genotypes were linked to changes such oxygen saturation, leukocyte count, liver function markers Paxlovid-treated Conclusions: These results highlight potential considering factors understanding individual responses informing future personalized approaches.

Language: Английский

Genetic Predictors of Paxlovid Treatment Response: The Role of IFNAR2, OAS1, OAS3, and ACE2 in COVID-19 Clinical Course DOI Open Access
Mykhailo Buchynskyi, Iryna Kamyshna, Iryna Halabitska

et al.

Journal of Personalized Medicine, Journal Year: 2025, Volume and Issue: 15(4), P. 156 - 156

Published: April 17, 2025

Background: This study investigated the role of genetic polymorphisms in IFNAR2, OAS1, OAS3, and ACE2 as predictors Paxlovid treatment response, specifically examining their influence on clinical course laboratory parameters COVID-19 patients. Methods: We analyzed impact genes associated with interferon pathway (IFNAR2 rs2236757), antiviral response (OAS1 rs10774671, OAS3 rs10735079), viral entry (ACE2 rs2074192) individuals treated Paxlovid. Results: Our findings suggest that variations these may modulate immune coagulation pathways context during infection. Specifically, IFNAR2 rs2236757 G allele was alterations inflammatory markers, while OAS1 influenced parameters. Furthermore, specific genotypes were linked to changes such oxygen saturation, leukocyte count, liver function markers Paxlovid-treated Conclusions: These results highlight potential considering factors understanding individual responses informing future personalized approaches.

Language: Английский

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