Asian Journal of Pharmaceutical and Clinical Research, Journal Year: 2025, Volume and Issue: unknown, P. 139 - 146
Published: April 7, 2025
Objectives: The current study aimed to prepare and optimize curcumin (CM) ethosomal gel for enhanced transdermal drug delivery overcome the poor permeability barrier. Methods: cold method was employed manufacture CM-loaded ethosomes with varying quantities of soya phosphatidylcholine, propylene glycol (PG), ethanol. Transmission electron microscopy evaluate appearance formed ethosomes. Formulation parameters such as vesicle size zeta potential, polydispersity index (PI), transition temperature, entrapment efficiency (EE), in vitro release, release kinetics, ex vivo studies on rat skin, pharmacokinetics, stability were performed. Results: results showed that CM have a smooth surface. adhered zero-order model. optimized formulation’s (CM5) potential PI determined be −7.28±1.62 mV 0.208, respectively, it has 90.8±1.8% EE 437±2 nm. maximum flux ethosome formulation 23.13±0.91 μg.h/cm2. bioavailability 7.61 times higher than control (oral suspension). revealed no significant change when stored at 4°C. Conclusion: Based research, vesicles may enhance dispersion without irritating skin. Ethosomes infused show administration management skin diseases.
Language: Английский
