Bistable dynamics of TAN-NK cells in tumor growth and control of radiotherapy-induced neutropenia in lung cancer treatment

Mathematical Biosciences & Engineering, Journal Year: 2025, Volume and Issue: 22(4), P. 744 - 809

Published: Jan. 1, 2025

Neutrophils play a crucial role in the innate immune response as first line of defense many diseases, including cancer. Tumor-associated neutrophils (TANs) can either promote or inhibit tumor growth various steps cancer progression via mutual interactions with cells complex microenvironment (TME). In this study, we developed and analyzed mathematical models to investigate natural killer (NK cells) dynamic transition between N1 N2 TAN phenotypes killing through key signaling networks how adjuvant therapy radiation be used combination increase anti-tumor efficacy. We examined immune-tumor dynamics among N1/N2 TANs, NK cells, communicating extracellular mediators (Transforming factor (TGF-$ \beta $), Interferon gamma (IFN-$ \gamma $)) intracellular regulation apoptosis network. several prevention strategies eradicate tumors, $, exogenous NK, TGF-$ $ inhibitor) optimally-controlled ionizing TME. Using model, investigated fundamental mechanism radiation-induced changes TME impact internal external composition on cell fate their different treatment schedules.

Language: Английский

Necroptosis-based glioblastoma prognostic subtypes: implications for TME remodeling and therapy response

Annals of Medicine, Journal Year: 2024, Volume and Issue: 56(1)

Published: Oct. 10, 2024

Background Glioblastoma (GBM) is an aggressive primary brain tumor with a high recurrence rate and poor prognosis. Necroptosis, pathological hallmark of GBM, poorly understood in terms its role prognosis, microenvironment (TME) alteration, immunotherapy.

Language: Английский