Journal of Translational Medicine,
Journal Year:
2022,
Volume and Issue:
20(1)
Published: Jan. 3, 2022
Exosomal
miRNAs
have
attracted
much
attention
due
to
their
critical
role
in
regulating
genes
and
the
altered
expression
of
virtually
all
cancers
affecting
humans
(Sun
et
al.
Mol
Cancer
17(1):14,
2018).
modulate
processes
that
interfere
with
cancer
immunity
microenvironment,
are
significantly
involved
tumor
growth,
invasion,
metastasis,
angiogenesis
drug
resistance.
Fully
investigating
detailed
mechanism
occurrence
development
various
could
help
not
only
treatment
but
also
prevention
malignant
diseases.
The
current
review
highlighted
recently
published
advances
regarding
cancer-derived
exosomes,
e.g.,
sorting
delivery
mechanisms
for
RNAs.
cell-to-cell
communication,
impacting
angiogenesis,
metastasis
multiple
biological
features,
were
discussed.
Finally,
potential
exosomal
as
diagnostic
prognostic
molecular
markers
was
summarized,
well
usefulness
detecting
resistance
therapeutic
agents.
Journal of Cell Science,
Journal Year:
2017,
Volume and Issue:
130(21), P. 3619 - 3630
Published: Oct. 13, 2017
ABSTRACT
Communication
is
important
to
ensure
the
correct
and
efficient
flow
of
information,
which
required
sustain
active
social
networks.
A
fine-tuned
communication
between
cells
vital
maintain
homeostasis
function
multicellular
or
unicellular
organisms
in
a
community
environment.
Although
there
are
different
levels
complexity,
intercellular
communication,
prokaryotes
mammalians,
can
occur
through
secreted
molecules
(either
soluble
encapsulated
vesicles),
tubular
structures
connecting
close
channels
that
link
cytoplasm
adjacent
cells.
In
mammals,
these
types
serve
purposes,
may
involve
distinct
factors
mediated
by
extracellular
vesicles,
tunnelling
nanotubes
gap
junctions.
Recent
studies
have
shown
connexin
43
(Cx43,
also
known
as
GJA1),
transmembrane
protein
initially
described
junction
protein,
participates
all
forms
communication;
this
emphasizes
concept
adopting
strategies
maximize
potential
available
resources
reutilizing
same
factor
scenarios.
Review,
we
provide
an
overview
most
recent
advances
regarding
role
Cx43
ACS Biomaterials Science & Engineering,
Journal Year:
2021,
Volume and Issue:
7(6), P. 2106 - 2149
Published: May 14, 2021
Exosomes
are
cell-derived
vesicles
containing
heterogeneous
active
biomolecules
such
as
proteins,
lipids,
mRNAs,
receptors,
immune
regulatory
molecules,
and
nucleic
acids.
They
typically
range
in
size
from
30
to
150
nm
diameter.
An
exosome's
surfaces
can
be
bioengineered
with
antibodies,
fluorescent
dye,
peptides,
tailored
for
small
molecule
large
biologics.
have
enormous
potential
a
drug
delivery
vehicle
due
enhanced
biocompatibility,
excellent
payload
capability,
reduced
immunogenicity
compared
alternative
polymeric-based
carriers.
Because
of
targeting
specificity,
exosomes
capable
delivering
their
cargo
exosome-recipient
cells.
Additionally,
potentially
act
early
stage
disease
diagnostic
tools
the
exosome
carries
various
protein
biomarkers
associated
specific
disease.
In
this
review,
we
summarize
recent
progress
on
composition,
biological
characterization,
isolation
techniques.
Finally,
outline
clinical
applications
preclinical
advancement
provide
an
outlook
importance
use
targeted
delivery,
biomarker
study,
vaccine
development.
Oncogene,
Journal Year:
2019,
Volume and Issue:
38(23), P. 4429 - 4451
Published: Feb. 27, 2019
Gap
junctions
comprise
arrays
of
intercellular
channels
formed
by
connexin
proteins
and
provide
for
the
direct
communication
between
adjacent
cells.
This
type
permits
coordination
cellular
activities
plays
key
roles
in
control
cell
growth
differentiation
maintenance
tissue
homoeostasis.
After
more
than
50
years,
deciphering
links
among
connexins,
gap
cancer,
researchers
are
now
beginning
to
translate
this
knowledge
clinic.
The
emergence
new
strategies
targeting,
combined
with
an
improved
understanding
molecular
bases
underlying
dysregulation
connexins
during
cancer
development,
offers
novel
opportunities
clinical
applications.
However,
different
isoforms
have
diverse
channel-dependent
-independent
functions
that
stage
specific.
can
elicit
both
pro-
anti-tumorigenic
effects
engender
significant
challenges
path
towards
personalised
medicine.
Here,
we
review
current
role
particular
focus
on
recent
progress
made
determining
their
prognostic
therapeutic
potential.
Hepatology,
Journal Year:
2020,
Volume and Issue:
74(1), P. 116 - 132
Published: Nov. 25, 2020
Background
ands
Aims
NAFLD
is
associated
with
elevation
of
many
cytokines,
particularly
IL‐6;
however,
the
role
IL‐6
in
remains
obscure.
The
aim
this
study
was
to
examine
how
myeloid‐specific
signaling
affects
by
regulation
antifibrotic
microRNA‐223
(miR‐223)
myeloid
cells.
Approach
and
Results
Patients
or
NASH
healthy
controls
were
recruited,
serum
soluble
receptor
α
(sIL‐6Rα)
measured.
Compared
controls,
sIL‐6Rα
levels
elevated
NAFLD/NASH
patients.
correlated
positively
number
circulating
leukocytes
monocytes.
investigated
Il6
knockout
(KO)
A
(
Il6ra
)
conditional
KO
mice
after
high‐fat
diet
(HFD)
feeding.
HFD‐fed
had
worse
liver
injury
fibrosis,
but
less
inflammation,
compared
wild‐type
mice.
Hepatocyte‐specific
more
steatosis
injury,
whereas
a
lower
hepatic
infiltrating
macrophages
(IMs)
neutrophils
increased
cell
death
these
cells,
greater
fibrosis
(LF),
than
WT
Mechanistically,
LF
HFD‐fed,
attributable
reduction
miR‐223
subsequent
up‐regulation
target
gene,
transcriptional
activator
PDZ‐binding
motif
(TAZ),
well‐known
factor
promote
fibrosis.
In
vitro
,
treatment
up‐regulated
exosome
biogenesis‐related
genes
subsequently
promoted
release
miR‐223‐enriched
exosomes
that
able
reduce
profibrotic
TAZ
expression
hepatocytes
exosomal
transfer.
Finally,
each
other
Conclusions
Myeloid‐specific
inhibits
through
transfer
into
hepatocytes,
providing
therapeutic
targets
for
therapy.
Journal of Translational Medicine,
Journal Year:
2022,
Volume and Issue:
20(1)
Published: Jan. 3, 2022
Exosomal
miRNAs
have
attracted
much
attention
due
to
their
critical
role
in
regulating
genes
and
the
altered
expression
of
virtually
all
cancers
affecting
humans
(Sun
et
al.
Mol
Cancer
17(1):14,
2018).
modulate
processes
that
interfere
with
cancer
immunity
microenvironment,
are
significantly
involved
tumor
growth,
invasion,
metastasis,
angiogenesis
drug
resistance.
Fully
investigating
detailed
mechanism
occurrence
development
various
could
help
not
only
treatment
but
also
prevention
malignant
diseases.
The
current
review
highlighted
recently
published
advances
regarding
cancer-derived
exosomes,
e.g.,
sorting
delivery
mechanisms
for
RNAs.
cell-to-cell
communication,
impacting
angiogenesis,
metastasis
multiple
biological
features,
were
discussed.
Finally,
potential
exosomal
as
diagnostic
prognostic
molecular
markers
was
summarized,
well
usefulness
detecting
resistance
therapeutic
agents.