The effect of COVID-19 during pregnancy on postpartum depression and mother-infant attachment

Irish Journal of Medical Science (1971 -), Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Abstract Background The psychiatric impacts of the COVID-19 pandemic are well-documented; however, its effects during postnatal period have been less explored. Aims We aimed to investigate effect on mother-infant attachment and depression in pregnant women pandemic. Methods study group consisted with diagnosis ‘pregnancy COVID-19’ after 20th gestational week ( n = 55). control included who did not a history their pregnancy or until date 52). Edinburgh Postpartum Depression Scale (EPDS) Attachment (PPAS) were administered participants. patients grouped according WHO classification. Results mean EPDS score was higher than (9.55 (7.17) vs. 6.65 (6.72) P 0.006)). There no difference between groups number individuals (EPDS > 13) PPAS factors. found be hospitalized 0.025). moderate severe disease mild (16 (8.49) 8.67 (6.57) 0.039)), there terms PPAS. Conclusion While presence has associated elevated postpartum scores women, hospitalization had at least one family member more illness resulted scores. does affect attachment. It is recommended that evaluated carefully for depression.

Language: Английский

Emerging Viral Infections (ZIKV, SARS‐CoV‐2, and MPXV) and Depression: Ketamine and (S, R)‐Ketamine as Promising Antidepressants

Reviews in Medical Virology, Journal Year: 2025, Volume and Issue: 35(3)

Published: April 9, 2025

ABSTRACT Emerging viral pathogens, newly reported or rapidly evolving viruses, are a significant public health concern worldwide. Beyond their characteristic clinical presentations, emerging such as monkeypox virus (MPXV) and severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), have been increasingly implicated in the development of various neuropsychiatric complications including depression, mainly due to ability induce neuroinflammation, immune dysfunction, neurotransmitter imbalances. Depression is common mental condition characterised by continuous low mood sadness, pessimism, anxiety, even tendency suicide main symptoms. Post depression commonly shows challenges, traditional antidepressant agents exhibit suboptimal efficacy prolonged onset action. Regarding this, ketamine its enantiomers, S‐ketamine R‐ketamine, recently received increasing attention potential options light potent effective properties. The present review describes underlying pathophysiological mechanisms associated with highlighting role neuroinflammation disturbances inneurotransmitter systems. It also discusses current evidence demonstrating effectiveness safety, especially case treatment‐resistant growing relevance for linked infections, depression. Although preliminary reports propose effectiveness, additional studies needed optimal treatment strategies, long‐term incorporation into practice. Addressing these challenges will be critical optimising ketamine‐ (S, R)‐ketamine‐containing therapeutic protocols treating infections.

Language: Английский

Analysis of Immunological Memory for John Cunningham Virus in a Mexican Population of Patients with Multiple Sclerosis Under Treatment

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2737 - 2737

Published: Nov. 29, 2024

Background/Objectives: Multiple sclerosis (MS) is a disease characterized by demyelination and axonal damage of the central nervous system. Despite observed benefits, highly effective treatment (HET)-based therapy has adverse effects, which include an increased risk developing progressive multifocal leukoencephalopathy (PML). Additionally, grows if patient antibodies for John Cunningham virus (JCV). The appearance PML rare, only one report been found in Mexico. objective this research was to determine analyze immunological memory JCV population Mexican patients with MS under treatment. Methods: All participants underwent complete medical history neurological evaluation. Once they signed their informed consent, blood sample taken against were present serum. Results: In total, 121 analyzed, consisted 62.8% women 37.2% men average age 42.28. three most common HETs received natalizumab (67.76%), followed teriflunomide fingolimod. Conclusions: seropositivity 62.8%, group, duration evolution 152.33 ± 93.37 months. Natalizumab used HET, despite this, positive association between antibody index fingolimod depression found. Also, correlation Ab within forms SPMS PPMS compared RRMS observed. No differences populations, type, MS.

Language: Английский