Targeting gut microbiota as a therapeutic approach for neurodegenerative diseases
Neuroprotection/Neuroprotection (Chichester, England. Print),
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 27, 2025
Abstract
Recent
evidence
suggests
a
more
important
role
of
the
gut
microbiota
in
neurodegenerative
diseases
(NDDs)
given
its
relationship
through
microbiota‐gut‐brain
as
an
active
communication
system
aiding
maintaining
homeostasis
between
brain
and
gut.
This
review
focuses
on
how
modulation
can
serves
therapeutic
strategy
for
NDDs,
emphasizing
neuroprotective
effects
probiotics.
Probiotics
are
live
microorganisms
that
confer
health
benefits,
their
interaction
with
gut‐microbiota
influences
neurogenesis,
neurotransmitter
regulation,
neuroinflammation.
advancements,
including
germ‐free
animal
models,
fecal
transplantation
(FMT),
diverse
probiotic
strains,
have
revealed
underlying
mechanisms
linking
to
function.
Notably,
several
Lactobacillus
Bifidobacterium
species
been
shown
exert
via
upregulation
neurotrophic
factors
such
brain‐derived
factor
enhancing
mitochondrial
function
reducing
impacts
oxidative
stress.
Interestingly,
FMT
has
exhibited
degree
success
overcoming
cognitive
impairment
motor
deficits
preclinical
studies
clinical
trials.
However,
further
research
is
warranted
explore
potential
humans.
Overall,
this
highlights
significant
NDDs
advocates
gut‐targeted
interventions
innovative
approaches
mitigate
these
diseases.
Language: Английский
Probiotics as Potential Treatments for Neurodegenerative Diseases: a Review of the Evidence from in vivo to Clinical Trial
Biomolecules & Therapeutics,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 16, 2024
Neurodegenerative
diseases
(NDDs),
characterized
by
the
progressive
deterioration
of
structure
and
function
nervous
system,
represent
a
significant
global
health
challenge.Emerging
research
suggests
that
gut
microbiota
plays
critical
role
in
regulating
neurodegeneration
via
modulation
gut-brain
axis.Probiotics,
defined
as
live
microorganisms
confer
benefits
to
host,
have
garnered
attention
owing
their
therapeutic
potential
NDDs.This
review
examines
current
trends
related
microbiome-gut-brain
axis
across
various
NDDs,
highlighting
key
findings
implications.Additionally,
effects
specific
probiotic
strains,
including
Lactobacillus
plantarum,
Bifidobacterium
breve,
rhamnosus,
on
neurodegenerative
processes
were
assessed,
focusing
benefits.Overall,
this
emphasizes
probiotics
promising
agents
for
underscoring
importance
further
investigation
into
emerging
field.
Language: Английский