Comparison of Operational Definition of Type 2 Diabetes Mellitus Based on Data from Korean National Health Insurance Service and Korea National Health and Nutrition Examination Survey

Diabetes & Metabolism Journal, Journal Year: 2023, Volume and Issue: 47(2), P. 201 - 210

Published: Feb. 8, 2023

Background: We evaluated the validity and reliability of operational definition type 2 diabetes mellitus (T2DM) based on Korean National Health Insurance Service (NHIS) database.Methods: Adult subjects (≥40 years old) included in Korea Nutrition Examination Survey (KNHANES) from 2008 to 2017 were merged with those NHIS health check-up database, producing a cross-sectional dataset. sensitivity, specificity, accuracy, agreement criteria for defining T2DM by comparing them KNHANES as standard reference.Results: In study population (n=13,006), two algorithms devised determine dataset whether diagnostic claim codes accompanied prescription anti-diabetic drugs (algorithm 1) or not 2). Using these algorithms, prevalence was 14.9% (n=1,942; algorithm 20.8% (n=2,707; Good observed both (Kappa index, 0.73 [algorithm 1], 0.63 2]). However, accuracy (0.93 vs. 0.89) specificity (0.96 0.90) tended be higher 1 than 2. The (accuracy, ranging 0.91 0.95) 0.68 0.78) independent age, sex, socioeconomic status, hypertension dyslipidemia.Conclusion: population-based claims data, including codes, could valid tool identify individuals population.

Language: Английский

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Inverse association between obesity and suicidal death risk

BMC Psychiatry, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 8, 2025

Abstract Background Suicide is a significant yet preventable public health issue. Body mass index (BMI) readily measurable indicator associated with various outcomes. However, the relationship between BMI and suicidal death risk complex warrants further investigation, particularly within contemporary, non-Western contexts consideration of potential confounders. The purpose this study was to investigate death. Methods This nationwide, retrospective, observational based on Korean National Health Insurance Service database. We analyzed 4,045,081 participants who were aged > 19 years underwent national surveillance in 2009. categorized according their (underweight: < 18.5 kg/m², normal weight: 18.5–23 overweight: 23–25 class I obesity: 25–30 II 30 kg/m²). primary outcome events caused by suicide which defined International Classification Disorders (ICD-10) codes (X60–X84) records documented Korea Statistical Office. Multivariate Cox proportional hazard regression analysis performed estimate respect categories after adjusting for confounders (age, sex, income, diabetes, hypertension, dyslipidemia, smoking, drinking, exercise, self-abuse, waist circumference, schizophrenia, bipolar disorder, eating cancer, anxiety, substance use disorder). Results Underweight individuals had an increased (hazard ratio [HR] 1.44, 95% confidence interval [CI] 1.31–1.57) while overweight (HR 0.79, CI 0.76–0.83), 0.76, 0.71–0.80) obesity 0.71, 0.63–0.81) decreased risks deaths compared those weight (BMI 18.5–23). trend consistent regardless presence major depressive disorder (MDD) or type living arrangements participants. Conclusions Suicidal inversely correlated categories, independent MDD arrangements. Our data suggests importance physiological factors body understanding risk. Furthermore, these provide valuable insights where resources should be invested reduce rates.

Language: Английский

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The impact of weight change on suicide mortality: a nationwide population-based cohort study of 2 million Koreans

Diabetology & Metabolic Syndrome, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 19, 2025

Abstract Background Previous studies have shown that weight change has a reverse J-shape association with all-cause mortality. However, its suicide mortality remains undetermined. In this study, we investigated the between and using large-scale, population-based cohort from Korean National Health Insurance Service database. Methods A total of 2,103,525 subjects aged ≥ 20 years who underwent general health screening program twice in 2-year interval 2007 2009 were included. Subjects categorized into five groups according to percent during period: severe loss (< − 15.0%), moderate (− 15.0 < 5.0%), stable 5.0 gain (5.0 (≥ 15.0%). Results During median follow-up 11.3 years, 6,179 cases (0.3%) occurred. Weight was associated increased J-shaped curve, even after adjustment for covariates. particular, those or showed 1.8-fold 1.6-fold risk mortality, respectively. This consistently observed subgroup analyses considering age, sex, depression, cancer, BMI category. Conclusions Moderate within is To better understand mechanisms through which affects incorporating information on intentions, medications, change-related medical conditions are needed.

Language: Английский

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Effects of Pancreatitis and Type 2 Diabetes Mellitus on the Development of Pancreatic Cancer: A Nationwide Nested Case-Control Study

Diabetes & Metabolism Journal, Journal Year: 2025, Volume and Issue: 49(2), P. 252 - 263

Published: March 1, 2025

Background: Despite diabetes mellitus (DM) and pancreatitis being known risk factors for pancreatic cancer, patients with these conditions are not included in cancer screening due to the low incidence of populations. This study aimed determine high-risk subgroup that would benefit from screening.Methods: A nested case-control was conducted using data National Health Information Database Korean Insurance Service. Patients were categorized into following groups: type 2 only (T2DM-only), pancreatitis-only (PAN-only), T2DM followed by (T2DM-PAN), post-pancreatitis (PPDM), no (NDNP). Conditional logistic regression used significant associations each group development risk.Results: The significantly higher T2DM-PAN (adjusted odds ratio [AOR], 4.96; 95% confidence interval [CI], 4.48 5.49) PPDM (AOR, 4.71; CI, 4.12 5.37) groups than NDNP group. Compared group, those insulin had a 17-fold increased 16.72; 9.50 29.43), individuals who less 3 years more 8-fold 8.83; 5.99 13.01).Conclusion: In diabetes, use or shorter duration associated suggesting subgroups may require close monitoring development.

Language: Английский

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Prevalence, Incidence, and Metabolic Characteristics of Young Adults with Type 2 Diabetes Mellitus in South Korea (2010–2020)

Diabetes & Metabolism Journal, Journal Year: 2025, Volume and Issue: 49(2), P. 172 - 182

Published: March 1, 2025

Background: This study aimed to examine trends in the prevalence, incidence, metabolic characteristics, and management of type 2 diabetes mellitus (T2DM) among young adults South Korea.Methods: Young with T2DM were defined as individuals aged 19 39 years who met diagnostic criteria for T2DM. Data from Korean National Health Insurance Service-Customized Database (2010–2020, <i>n</i>=225,497–372,726) analyzed evaluate profiles, comorbidities, antidiabetic drug prescription. Additional analyses performed using Korea Nutrition Examination Survey.Results: The prevalence significantly increased 1.02% 2010 2.02% 2020 (<i>P</i><0.001), corresponding 372,726 patients 2020. Over same period, incidence rate remained stable within range 0.36% 0.45%. Prediabetes steadily 15.53% 20.92%, affecting 3.87 million proportion obese also increased, 67.8% having a body mass index (BMI) ≥25 kg/m² 31.6% BMI ≥30 hypertension, dyslipidemia, fatty liver disease reaching 34.2%, 79.8%, 78.9%, respectively, Although overall pharmacological treatment low, prescription medications weight-reducing properties over period.Conclusion: nearly doubled past decade. strong association obesity comorbidities emphasizes urgent need targeted prevention strategies tailored this population.

Language: Английский

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Association between glycaemic status and the risk of acromegaly: a nationwide population-based cohort study

BMJ Open, Journal Year: 2025, Volume and Issue: 15(3), P. e087884 - e087884

Published: March 1, 2025

Objectives Although evidence suggests that the overall prevalence of type 2 diabetes mellitus (T2DM) was already higher in acromegaly group than general population several years before diagnosis, effect glycaemic status on risk developing remains unclear. Design Retrospective cohort study. Setting Data were obtained from National Health Insurance Services Korea. Baseline defined based fasting plasma glucose levels and prescription records, it classified into three categories: normal (NFG), impaired (IFG) or five NFG, IFG, new-onset T2DM, well-controlled T2DM poorly controlled T2DM. Participants A total 9 707 487 adults without participated national health screening programme 2009 followed up until 2019. Primary secondary outcome measures The main interest diagnosis incident acromegaly. Results Over a median follow-up period 9.2 years, 434 people (4.5 cases per 100 000 people) developed at least 1 year after enrolment. with IFG exhibited an increased acromegaly, hazard ratios (HR) 2.27 (95% CI 1.84 to 2.80) 2.45 1.78 3.39), respectively, compared those NFG. When participants categorised groups, observed (HR 2.18, 95% 1.38 3.43) 2.29, 1.28 4.09), similar individuals highest found 3.07, 1.88 5.01). These associations are persistent across various subgroups, regardless age, sex, lifestyle factors presence comorbidities. Conclusions results this study supported alterations metabolism, including associated

Language: Английский

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Long-term survival prediction in patients with acute brain lesions using ensemble machine learning algorithms: a cohort study with combined national health insurance service and its self-run hospital database

Journal Of Big Data, Journal Year: 2025, Volume and Issue: 12(1)

Published: April 1, 2025

Language: Английский

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Risk of Cardiovascular Disease According to the Precedence Relationship Between Hypertension and Diabetes Mellitus

Healthcare, Journal Year: 2025, Volume and Issue: 13(7), P. 796 - 796

Published: April 2, 2025

Background/Objectives: Cardiovascular disease (CVD) risk may be based on the sequence of hypertension (HTN) and diabetes mellitus (DM) occurrence since pathophysiological mechanisms might not same. The present study examined CVD according to precedent relationship between HTN DM. Methods: Participants with both DM in a national health screening program 2015-2016 were divided into two groups order occurrence: 'HTN → DM' 'DM HTN'. primary outcomes newly diagnosed myocardial infarction (MI) ischemic stroke International Classification Diseases, 10th revision code. Results: Among 914,338 participants, there 28,368 MI events 35,632 during follow-up period. group showed higher (adjusted hazard ratio [aHR]: 1.13 [95% CI: 1.10-1.15]) (aHR: 1.06 1.04-1.09]) than group. increased was more prominent females males those without dyslipidemia dyslipidemia. A DM-HTN found patients chronic kidney (CKD) CKD. Conclusions: frequent When approaching clinically epidemiologically, phenotypes should considered. Given generalization limitations Asian patients, who develop at an early age compared other groups, future studies are needed reveal underlying mechanism precedence

Language: Английский

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Nationwide big data analysis of inguinal hernia surgery trends in South Korea (2016–2022)

Annals of Surgical Treatment and Research, Journal Year: 2025, Volume and Issue: 108(4), P. 211 - 211

Published: Jan. 1, 2025

This study aimed to analyze nationwide trends and regional disparities in inguinal hernia surgeries South Korea between 2016 2022. Additionally, we evaluate changes surgery frequency, including urban concentration the introduction of robotic surgery. retrospective review used data on from Health Insurance Review Assessment Service database. From 2022, 254,367 were performed Korea, with males accounting for 88.9% cases. The annual number fluctuated, particularly 2020, owing coronavirus disease 2019 pandemic. Medical costs increased $1,218.4 $1,970 average, whereas patient copayments rose $180.2 $293.3. Robotic surgeries, introduced 2019, 226 cases Pediatric steadily declined, adult remained stable, a slight increase average hospital stay did not change significantly but varied pediatric patients. Regional notable, especially rates metropolitan areas, such as Seoul surrounding provinces. highlights stable overall rates, decline cases, an surgeries. persistent healthcare services areas suggests need policy interventions address ensure equitable access. findings underscore importance ongoing efforts improve distribution long-term strategies changing surgical trends.

Language: Английский

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Association Between Metabolic Syndrome and Young-Onset Dementia

Neurology, Journal Year: 2025, Volume and Issue: 104(10)

Published: April 23, 2025

Young-onset dementia (YOD) poses substantial societal and health care burdens. Although metabolic syndrome (MetS) is recognized as a contributor to late-onset dementia, its effect on YOD remains unclear. This study aimed determine whether MetS individual components increase the risk of YOD, including all-cause Alzheimer disease (AD), vascular (VaD). We conducted nationwide population-based cohort using data from Korean National Insurance Service. Individuals aged 40-60 who underwent national check-ups in 2009 were included followed until December 31, 2020, or age 65, whichever came first. was defined according established guidelines, incorporating measurements waist circumference, blood pressure, fasting glucose, triglycerides, high-density lipoprotein cholesterol. Covariates age, sex, income level, smoking status, alcohol consumption, comorbidities such hypertension, diabetes, dyslipidemia, depression. The primary outcome incident diagnosis before 65; secondary outcomes young-onset AD VaD. Multivariable Cox proportional hazards models used estimate hazard ratios (HRs) with 95% CIs. A total 1,979,509 participants (mean 49.0 years; 51.3% men; 50.7% MetS) included. Over an average follow-up 7.75 years, 8,921 individuals (0.45%) developed YOD. associated 24% higher (adjusted HR 1.24, CI 1.19-1.30), 12.4% increased (HR 1.12, 1.03-1.22), 20.9% VaD 1.21, 1.08-1.35). Significant interactions noted younger (40-49 vs 50-59), female drinking obesity, In this large cohort, significantly These findings suggest that interventions targeting may help mitigate risk. However, observational design precludes definitive causal inferences, reliance claims could introduce misclassification bias. Future research longitudinal designs comprehensive collection needed validate expand these associations.

Language: Английский

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