Association between Dietary Quality and Non-Alcoholic Fatty Liver Disease in Korean Adults: A Nationwide, Population-Based Study Using the Korean Healthy Eating Index (2013–2021) DOI Creative Commons
Seong‐Uk Baek, Taeyeon Kim, Yu‐Min Lee

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(10), P. 1516 - 1516

Published: May 17, 2024

This study explored the relationship between Korean Healthy Eating Index (KHEI) and non-alcoholic fatty liver disease (NAFLD). cross-sectional included 34,174 adults. The KHEI was composed of three subcomponents (adequacy, moderation, energy balance) calculated based on a 24 h dietary recall. total score ranged from 0 to 100, with higher indicating greater adherence guidelines. scores were categorized into quartiles (Q1–Q4). NAFLD classified using hepatic steatosis index. Logistic regressions used estimate odds ratios (ORs) 95% confidence intervals (CIs). adjusted OR (95% CI) 0.95 (0.87–1.03) for Q2 group, 0.90 (0.83–0.98) Q3 0.79 (0.72–0.87) Q4 compared Q1 group. Among KHEI, individuals high in adequacy component, characterized by an abundant consumption fruits, vegetables, dairy products, exhibited most pronounced association NAFLD. A negatively associated Therefore, promotion healthy patterns can play beneficial role prevention or management

Language: Английский

Association of non-alcoholic fatty liver disease with cardiovascular disease and all cause death in patients with type 2 diabetes mellitus: nationwide population based study DOI Creative Commons
Kyung‐Soo Kim, Sangmo Hong, Kyungdo Han

et al.

BMJ, Journal Year: 2024, Volume and Issue: unknown, P. e076388 - e076388

Published: Feb. 13, 2024

Abstract Objective To investigate the risk of non-alcoholic fatty liver disease (NAFLD) for cardiovascular and all cause death in patients with type 2 diabetes mellitus (T2DM). Design Nationwide population based study. Setting Longitudinal cohort study Korea. Participants 7 796 763 participants National Health Screening Programme 2009 were divided into three groups on NAFLD status: no (fatty index<30); grade 1 (30≤fatty index<60); index≥60). Median follow-up was 8.13 years. Main outcome measures The primary incident (myocardial infarction, ischaemic stroke) or death. Results Of participants, 6.49% (n=505 763) had T2DM. More T2DM (34.06%) (26.73%) than those without (grade NAFLD: 21.20%; 10.02%). incidence rate (per 1000 person years) increased order NAFLD, rates higher five year absolute (no T2DM: 1.03, 95% confidence interval 1.02 to 1.04, 1.25, 1.24 1.26, respectively; 1.23, 1.22 1.50, 1.48 1.51, 1.42, 1.40 1.45, 2.09, 2.06 2.12, 3.34, 3.27 3.41, 3.68, 3.61 3.74, 3.94, 3.87 4.02, 4.25, 4.18 4.33, 4.66, 4.54 4.78, 5.91, 5.78 6.05, respectively). Patients a NAFLD. Risk differences between Conclusions seems be associated death, even mild group

Language: Английский

Citations

62
Mortality in metabolic dysfunction-associated steatotic liver disease: A nationwide population-based cohort study DOI
Eugene Han, Byung‐Wan Lee, Eun Seok Kang

et al.

Metabolism, Journal Year: 2024, Volume and Issue: 152, P. 155789 - 155789

Published: Jan. 13, 2024

Language: Английский

Citations

19
Hepatic Fibrosis and Cancer: The Silent Threats of Metabolic Syndrome DOI Creative Commons
Scott L. Friedman

Diabetes & Metabolism Journal, Journal Year: 2024, Volume and Issue: 48(2), P. 161 - 169

Published: Jan. 26, 2024

Metabolic dysfunction-associated steatotic (fatty) liver disease (MASLD), previously termed non-alcoholic fatty disease, is a worldwide epidemic that can lead to hepatic inflammation, fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). The typically component of the metabolic syndrome accompanies obesity, often overlooked because manifestations are clinically silent until late-stage present (i.e., cirrhosis). Moreover, Asian populations, including Koreans, have higher fraction patients who lean, yet their illness has same prognosis or worse than those obese. Nonetheless, ongoing injury inflammation ballooning hepatocytes as classic features. Over time, fibrosis develops following activation stellate cells, liver’s main fibrogenic cell type. usually more advanced in with type 2 diabetes mellitus, indicating all diabetic should be screened for disease. Although there been substantial progress clarifying pathways no approved therapies yet, but current research seeks uncover driving hopes identifying new therapeutic targets. Emerging molecular methods, especially single sequencing technologies, revolutionizing our ability clarify mechanisms underlying MASLD-associated HCC.

Language: Английский

Citations

14
Liver cancer risk across metabolic dysfunction-associated steatotic liver disease and/or alcohol: a nationwide study DOI
Byungyoon Yun, Heejoo Park, Sang Hoon Ahn

et al.

The American Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: unknown

Published: June 27, 2024

INTRODUCTION: New terminologies of metabolic dysfunction-associated steatotic liver disease (MASLD) have been developed. We assessed hepatocellular carcinoma (HCC) risk across MASLD and/or alcohol intake. METHODS: included participants aged 40–79 years receiving a national health checkup from 2009 to 2010 in the Republic Korea, classified as follows: non-MASLD, MASLD, with increased intake (MetALD; weekly 210–420 g for male and 140–350 female individuals), alcohol-associated (ALD; excessive ≥420 or ≥350 individuals). The primary outcome was HCC incidence. estimated using multivariable Cox proportional hazard models. RESULTS: Among 6,412,209 participants, proportions MetALD, ALD cases were 59.5%, 32.4%, 4.8%, 3.4%, respectively. During follow-up (median 13.3 years), 27,118 had newly developed HCC. Compared (adjusted ratio [aHR] 1.66, 95% confidence interval [CI] 1.62–1.71) MetALD (aHR 2.17, CI 2.08–2.27) 2.34, 2.24–2.45) stepwise manner. Furthermore, older non-cirrhosis subgroups more vulnerable detrimental effects intake, concerning risk. older, female, cirrhosis subgroups, poses similar risks ALD. DISCUSSION: manner, compared non-MASLD. For an effective prevention HCC, comprehensive approach should be required modify both dysfunction habit.

Language: Английский

Citations

10
Big Data Research for Diabetes-Related Diseases Using the Korean National Health Information Database DOI Creative Commons
Kyung‐Soo Kim, Bongseong Kim, Kyungdo Han

et al.

Diabetes & Metabolism Journal, Journal Year: 2025, Volume and Issue: 49(1), P. 13 - 21

Published: Jan. 1, 2025

The Korean National Health Information Database (NHID), which contains nationwide real-world claims data including sociodemographic data, health care utilization screening and healthcare provider information, is a powerful resource to test various hypotheses. It also longitudinal in nature due the recommended checkup every 2 years appropriate for long-term follow-up study as well evaluating relationships between outcomes changes parameters such lifestyle factors, anthropometric measurements, laboratory results. However, because these are not collected research purposes, precise operational definitions of diseases required facilitate big analysis using NHID. In this review, we describe characteristics NHID, used related diabetes, introduce representative diabetes-related

Language: Английский

Citations

1
Insulin Resistance, Non-Alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus: Clinical and Experimental Perspective DOI Creative Commons
Inha Jung, Dae-Jeong Koo, Won‐Young Lee

et al.

Diabetes & Metabolism Journal, Journal Year: 2024, Volume and Issue: 48(3), P. 327 - 339

Published: Feb. 4, 2024

It has been generally accepted that insulin resistance (IR) and reduced secretory capacity are the basic pathogenesis of type 2 diabetes mellitus (T2DM). In addition to genetic factors, persistence systemic inflammation caused by obesity associated threat lipotoxicity increase risk T2DM. particular, main cause IR is subjects with T2DM have a higher body mass index (BMI) than normal according recent studies. The prevalence increased increasing BMI during past three decades. According studies, homeostatic model assessment was compared 1990s. Rising in Korea contributed development IR, non-alcoholic fatty liver disease cutting this vicious cycle important. My colleagues I investigated pathogenic mechanism on theme through clinical experimental studies over 20 years herein, would like summarize some our deep gratitude for receiving prestigious 2023 Sulwon Award.

Language: Английский

Citations

8
The Role of the Fatty Liver Index (FLI) in the Management of Non-Alcoholic Fatty Liver Disease: A Systematic Review DOI Creative Commons
Teodora Biciusca, Sorina Ionelia Stan, Mara Amalia Bălteanu

et al.

Diagnostics, Journal Year: 2023, Volume and Issue: 13(21), P. 3316 - 3316

Published: Oct. 26, 2023

Currently, non-alcoholic fatty liver disease is the most common worldwide, with a prevalence of 32%. It much more among men (40%) and patients metabolic comorbidities such as obesity, diabetes dyslipidemia. Being an asymptomatic disease, diagnosis often established on basis imaging methods, important role given to abdominal ultrasonography, computed tomography magnetic resonance imaging. In order facilitate diagnosis, experts have introduced series blood biomarkers. Two biomarker panels are currently validated for disease: index, hepatic steatosis index. The index has been in use medical practice over 17 years demonstrated its accuracy various studies that compared it other diagnostic highlighted screening cardiovascular risk effects different diets drugs proposed treatment disease. management algorithm prognosis risk. Taking into account diversity be approved will become effective tool monitoring these therapies.

Language: Английский

Citations

15
Prevalence, Incidence, and Metabolic Characteristics of Young Adults with Type 2 Diabetes Mellitus in South Korea (2010–2020) DOI Creative Commons
Ji Yoon Kim, Jiyoon Lee, Joon Ho Moon

et al.

Diabetes & Metabolism Journal, Journal Year: 2025, Volume and Issue: 49(2), P. 172 - 182

Published: March 1, 2025

Background: This study aimed to examine trends in the prevalence, incidence, metabolic characteristics, and management of type 2 diabetes mellitus (T2DM) among young adults South Korea.Methods: Young with T2DM were defined as individuals aged 19 39 years who met diagnostic criteria for T2DM. Data from Korean National Health Insurance Service-Customized Database (2010–2020, <i>n</i>=225,497–372,726) analyzed evaluate profiles, comorbidities, antidiabetic drug prescription. Additional analyses performed using Korea Nutrition Examination Survey.Results: The prevalence significantly increased 1.02% 2010 2.02% 2020 (<i>P</i><0.001), corresponding 372,726 patients 2020. Over same period, incidence rate remained stable within range 0.36% 0.45%. Prediabetes steadily 15.53% 20.92%, affecting 3.87 million proportion obese also increased, 67.8% having a body mass index (BMI) ≥25 kg/m² 31.6% BMI ≥30 hypertension, dyslipidemia, fatty liver disease reaching 34.2%, 79.8%, 78.9%, respectively, Although overall pharmacological treatment low, prescription medications weight-reducing properties over period.Conclusion: nearly doubled past decade. strong association obesity comorbidities emphasizes urgent need targeted prevention strategies tailored this population.

Language: Английский

Citations

0
Impact of steatotic liver disease categories on atrial fibrillation in type 2 diabetes: a nationwide study DOI Creative Commons

So Hyun Cho,

Gyuri Kim,

Kyu‐na Lee

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 3, 2025

Language: Английский

Citations

0
Increased Risk of Early-Onset Endometrial Cancer in Women Aged 20–39 Years with Non-Alcoholic Fatty Liver Disease: A Nationwide Cohort Study DOI Open Access
Joo‐Hyun Park, Jung Yong Hong, Kyungdo Han

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(8), P. 1322 - 1322

Published: April 14, 2025

Background/Objectives: Given the rising incidence of early-onset endometrial cancer diagnosed before age 50 years, this study examined whether non-alcoholic fatty liver disease (NAFLD) served as an independent risk factor for cancer, irrespective obesity status. Methods: This nationwide cohort included 2,311,949 Korean women aged 20–39 years who underwent health screenings from 2009 to 2012. NAFLD severity was classified based on index: none (<30), moderate (30–59), and severe (≥60). Multivariable-adjusted Cox proportional hazards models were applied estimate adjusted hazard ratios (aHRs) cancer. Results: During a median follow-up 7.6 1289 developed The cumulative significantly higher in with than those without (log-rank p < 0.001). A dose-dependent association observed, increased corresponding greater (aHR [95% confidence interval (CI)]: NAFLD, 2.38 [1.99–2.85]; 5.39 [4.44–6.53]; trend 0.01). Compared non-obese aHRs 2.53 [2.11–3.05] 1.66 [1.10–2.52] obese 4.30 [3.60–5.13] (synergy index = 1.50, Conclusions: independently associated both women. Furthermore, young exhibited synergistically elevated risk. Early identification management may help mitigate rapidly growing burden

Language: Английский

Citations

0