Scouting Biomarkers for Alzheimer’s Disease via Network Analysis of Exosome Proteomics Data

BioMedInformatics, Journal Year: 2025, Volume and Issue: 5(2), P. 19 - 19

Published: April 8, 2025

Background: Exosomes are a group of extracellular vesicles that released by almost all mammalian cell types and engage in intracellular communication. Studies conducted recent years have shown exosomes involved variety diseases, where they may act as “vehicles” for the transmission biomolecules biomolecular information. Amyloidoses constitute critical subgroup these caused deposition or inclusions insoluble protein fibrils cells tissues. However, how diseases remains largely unexplored. Methods: To detect possible links between amyloid proteins exosomes, data from amyloidosis-isolated were collected visualized using biological networks. Results: This biomedical informatics approach analysis interaction networks, combination with existing literature, highlighted involvement amyloidosis while strengthening hypotheses regarding their mechanism action. Conclusion: work is focused on patients Alzheimer’s disease identifies important amyloidogenic found exosomes. These can be used future research field exosome-based biomarkers potential prognostic preventive approaches.

Language: Английский

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Exosomes-based Applications in Companion Animals: Diagnostics and Therapeutics in Dogs and Cats

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106958 - 106958

Published: April 1, 2025

Language: Английский

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Post-COVID-19 Parkinsonism and Parkinson’s Disease Pathogenesis: The Exosomal Cargo Hypothesis

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(17), P. 9739 - 9739

Published: Aug. 28, 2022

Parkinson’s disease (PD) is the second most prevalent neurodegenerative after Alzheimer’s disease, globally. Dopaminergic neuron degeneration in substantia nigra pars compacta and aggregation of misfolded alpha-synuclein are PD hallmarks, accompanied by motor non-motor symptoms. Several viruses have been linked to appearance a post-infection parkinsonian phenotype. Coronavirus 2019 (COVID-19), caused emerging severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, has evolved from novel pneumonia multifaceted with multiple clinical manifestations, among which neurological sequalae appear insidious potentially long-lasting. Exosomes extracellular nanovesicles bearing complex cargo active biomolecules playing crucial roles intercellular communication under pathophysiological conditions. constitute reliable route for protein transmission, contributing pathogenesis diagnosis. Herein, we summarize recent evidence suggesting that SARS-CoV-2 infection shares numerous manifestations inflammatory molecular pathways PD. We carry on hypothesizing these similarities may be reflected exosomal modulated virus correlation severity. Travelling periphery brain, SARS-CoV-2-related contains RNA, viral proteins, mediators, modified host proteins could operate as promoters neuroinflammatory cascades, leading future parkinsonism development.

Language: Английский

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Ductal delivery of extracellular vesicles promote the recovery from salivary gland inflammation

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 357, P. 235 - 248

Published: April 5, 2023

Language: Английский

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Extracellular vesicles (EVs)’ journey in recipient cells: from recognition to cargo release

Journal of Zhejiang University SCIENCE B, Journal Year: 2024, Volume and Issue: 25(8), P. 633 - 655

Published: Aug. 1, 2024

Language: Английский

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