Aging and Disease,
Journal Year:
2023,
Volume and Issue:
unknown, P. 0 - 0
Published: Jan. 1, 2023
Lactic
Acid
Bacteria
(LAB)
are
beneficial
microorganisms
widely
utilized
in
food
fermentation
processes
and
as
probiotic
supplements.
They
offer
multifarious
health
benefits,
including
enhancing
digestion,
strengthening
immune
mechanisms,
mitigating
inflammation.
Recent
studies
suggest
that
LAB
might
be
instrumental
the
anti-aging
domain,
modulating
key
molecular
pathways
involved
aging
continuum,
such
IL-13,
TNF-α,
mTOR,
IFN-γ,
TGF-β,
AMPK,
GABA.
The
TLR
family,
particularly
TLR2,
appears
pivotal
during
primary
cellular
interactions
with
bacteria
their
byproducts.
Concurrently,
Sirtuin
predominantly
Sirtuin-1,
plays
diverse
roles
upon
stimuli
by
bacterial
components.
potential
benefits
postulated
include
restoring
gut
balance,
antioxidant
potential,
fortifying
cognitive
mental
faculties.
However,
current
body
of
evidence
is
still
embryonic
calls
for
expansive
human
trials
deeper
mechanistic
analyses.
safety
optimal
consumption
metrics
also
warrant
rigorous
evaluation.
Future
research
trajectories
should
identify
specific
strains
potent
properties
unravel
underlying
biological
pathways.
Given
promising
implications,
stand
dietary
contenders
to
foster
healthy
enrich
quality
life
among
elderly
population.
Egyptian Rheumatology and Rehabilitation,
Journal Year:
2023,
Volume and Issue:
50(1)
Published: Sept. 11, 2023
Abstract
Background
Sarcopenia
is
a
syndrome
characterized
by
progressive
decline
in
muscle
mass
and
strength,
with
subsequent
deterioration
of
functional
performance
increased
morbidity
mortality.
Its
emergence
may
be
associated
disorders
that
are
not
limited
to
the
elderly.
The
multifactorial
nature
sarcopenia
major
barrier
diagnosis.
Several
risk
factors
contribute
development
sarcopenia,
including
age,
gender,
amount
physical
activity.
Additionally,
pathophysiology
involves
inflammatory
conditions,
endocrinal
dysfunction,
metabolic
alterations.
studies
have
proposed
numerous
molecules
linked
pathogenesis
could
useful
future;
however,
there
an
unmet
need
discover
sensitive,
reliable,
cost-effective
biomarker
aging.
Main
text
objective
this
research
highlight
different
biomarkers
reflect
its
pathophysiology.
A
narrative
review
was
carried
out
through
series
literature
searches
database
MEDLINE/PubMed
focusing
on
biomarkers.
following
search
terms
were
used:
“sarcopenia,”
“osteosarcopenia,”
“muscle
ageing,”
failure,”
“sarcopenic
obesity,”
“weakness,”
“biomarkers,”
“frailty,”
“comorbidity,”
“functional
disability,”
“inflamm-aging.”
observational
peer-reviewed.
They
all
at
referral
center,
hospital,
or
community.
articles
chosen
contained
information
about
sarcopenia.
Case
reports
did
assess
people's
aging
considered.
Conclusion
Despite
availability
functional,
imaging,
biological
markers,
inherent
limitations
assessment
tools
make
it
difficult
objectively
measure
various
domains.
valid
reliable
has
yet
identified.
identification
“gold
standard”
evaluation
techniques
should
systematically
used
also
impacted
variability
populations
assessed.
In
context,
establishment
international
consensus
adopting
multi-biomarker
approach
utmost
importance
tackle
aspects
health-related
problem.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(12), P. 6678 - 6678
Published: June 18, 2024
Alzheimer’s
disease
(AD)
is
a
prevalent
neurodegenerative
disorder
and
leading
cause
of
dementia.
Aging
significant
risk
factor
for
AD,
emphasizing
the
importance
early
detection
since
symptoms
cannot
be
reversed
once
advanced
stage
reached.
Currently,
there
no
established
method
AD
diagnosis.
However,
emerging
evidence
suggests
that
microbiome
has
an
impact
on
cognitive
function.
The
gut
brain
communicate
bidirectionally
through
gut–brain
axis,
with
systemic
inflammation
identified
as
key
connection
may
contribute
to
AD.
Gut
dysbiosis
more
in
individuals
compared
their
cognitively
healthy
counterparts,
increased
permeability
subsequent
inflammation,
potentially
causing
neuroinflammation.
Detecting
activity
traditionally
involves
invasive
expensive
methods,
but
electroencephalography
(EEG)
poses
non-invasive
alternative.
EEG
measures
multiple
studies
indicate
distinct
patterns
Furthermore,
mild
impairment
differ
from
those
suggesting
its
potential
indication
This
review
aims
consolidate
existing
knowledge
biomarkers
early-stage
highlighting
current
state
research
avenues
further
investigation.
Nutritional Neuroscience,
Journal Year:
2022,
Volume and Issue:
26(11), P. 1159 - 1171
Published: Oct. 12, 2022
Emerging
evidence
is
highlighting
the
microbiome
as
a
key
regulator
of
effect
nutrition
on
gut-brain
axis
signaling.
Nevertheless,
it
not
yet
clear
whether
impact
moderating
microbiota-gut-brain
interaction
or
if
diet
has
mediating
role
microbiota
composition
and
function
to
influence
central
nervous
system
function,
brain
phenotypes
behavior.
Mechanistic
from
cell-based
in
vitro
studies,
animal
models
preclinical
intervention
studies
are
linking
gut
effects
but
they
have
had
limited
translation
human
studies.
While
increasing
demonstrates
triangulating
relationship
between
diet,
microbiota,
across
lifespan,
future
mechanistic
translational
field
nutritional
neuroscience
warranted
inform
potential
strategies
for
prevention
management
several
neurological,
neurodevelopmental,
neurodegenerative,
psychiatric
disorders.
This
brief
primer
provides
an
overview
most
recent
advances
-
field,
significant
opportunities
research.
Aging and Disease,
Journal Year:
2023,
Volume and Issue:
unknown, P. 0 - 0
Published: Jan. 1, 2023
Lactic
Acid
Bacteria
(LAB)
are
beneficial
microorganisms
widely
utilized
in
food
fermentation
processes
and
as
probiotic
supplements.
They
offer
multifarious
health
benefits,
including
enhancing
digestion,
strengthening
immune
mechanisms,
mitigating
inflammation.
Recent
studies
suggest
that
LAB
might
be
instrumental
the
anti-aging
domain,
modulating
key
molecular
pathways
involved
aging
continuum,
such
IL-13,
TNF-α,
mTOR,
IFN-γ,
TGF-β,
AMPK,
GABA.
The
TLR
family,
particularly
TLR2,
appears
pivotal
during
primary
cellular
interactions
with
bacteria
their
byproducts.
Concurrently,
Sirtuin
predominantly
Sirtuin-1,
plays
diverse
roles
upon
stimuli
by
bacterial
components.
potential
benefits
postulated
include
restoring
gut
balance,
antioxidant
potential,
fortifying
cognitive
mental
faculties.
However,
current
body
of
evidence
is
still
embryonic
calls
for
expansive
human
trials
deeper
mechanistic
analyses.
safety
optimal
consumption
metrics
also
warrant
rigorous
evaluation.
Future
research
trajectories
should
identify
specific
strains
potent
properties
unravel
underlying
biological
pathways.
Given
promising
implications,
stand
dietary
contenders
to
foster
healthy
enrich
quality
life
among
elderly
population.
