Epigenetics Insights, Journal Year: 2024, Volume and Issue: 17(1), P. 0 - 0
Published: Jan. 1, 2024
Language: Английский
Experimental Neurology, Journal Year: 2024, Volume and Issue: 379, P. 114868 - 114868
Published: June 18, 2024
Language: Английский
Citations
7
Egyptian Journal of Medical Human Genetics, Journal Year: 2025, Volume and Issue: 26(1)
Published: March 4, 2025
Abstract Background Huntington's disease (HD) could cause progressive motor deficits, psychiatric symptoms, and cognitive impairment. With the increasing use of pharmacotherapies theoretically target neurotransmitters, incidence HD is still not decreasing. However, molecular pathogenesis have been illuminate. It momentous to further examine HD. Methods The next generation sequencing dataset GSE105041 was downloaded from Gene Expression Omnibus (GEO) database. Using DESeq2 in R bioconductor package screen differentially expressed genes (DEGs) between samples normal control samples. ontology (GO) term REACTOME pathway enrichment were performed on DEGs. Meanwhile, using Integrated Interactions Database (IID) database Cytoscape software construct protein–protein interaction (PPI) network module analysis, identify hub with highest value node degree, betweenness, stress closeness scores. miRNA-hub gene regulatory TF-hub constructed analyzed. Receiver operating characteristic curves analysis for diagnostic genes. Results We identified 958 DEGs, consisting 479 up regulated DEGs down GO terms analyses by g:Profiler online results revealed that mainly enriched multicellular organismal process, developmental signaling GPCR MHC class II antigen presentation. Network Analyzer plugin PPI network, LRRK2, MTUS2, HOXA1, IL7R, ERBB3, EGFR, TEX101, WDR76, NEDD4L COMT selected as Hsa-mir-1292-5p, hsa-mir-4521, ESRRB SREBF1 are potential biomarkers predicted be associated Conclusion This study investigated key pathways interactions its complications, which might help reveal correlation complications. current investigation captured prediction, follow-up biological experiments enforced validation.
Language: Английский
Citations
0
Neural Regeneration Research, Journal Year: 2023, Volume and Issue: 19(6), P. 1360 - 1366
Published: Oct. 2, 2023
Abstract JOURNAL/nrgr/04.03/01300535-202406000-00041/inline-graphic1/v/2023-10-30T152229Z/r/image-tiff Neuroinflammation exacerbates secondary damage after spinal cord injury, while microglia/macrophage pyroptosis is important to neuroinflammation. Circular RNAs (circRNAs) play a role in the central nervous system. However, functional and mechanism of circRNAs regulating injury are still poorly studied. In present study, we detected female rat model along with upregulated levels circ0000381 cord. Our further experimental results suggest that may function as sponge sequester endogenous microRNA423-3p (miR-423-3p), which can increase expression NOD-like receptor 3 (NLRP3), marker. Therefore, upregulation be compensatory change attenuate pyroptosis. Indeed, knockdown exacerbated Collectively, our findings provide novel evidence for circ0000381, serve neuroprotective injury. Accordingly, therapeutic target treatment
Language: Английский
Citations
4
Journal of Cancer, Journal Year: 2024, Volume and Issue: 15(12), P. 3984 - 3994
Published: Jan. 1, 2024
Head and neck squamous cell carcinoma (HNSCC) represents the predominant malignancies in head region, has limited therapeutic alternatives. Circular RNAs (circRNAs), a substantial category of non-coding RNA molecules, exert influential roles human disease development progression, employing various mechanisms such as microRNA sponging, interaction with RNA-binding proteins, translational capabilities. Accumulating evidence highlights differential expression numerous circRNAs HNSCC, dysregulated underscore their crucial involvement malignant advancement resistance to treatment. This review aims comprehensively outline characteristics, biogenesis, circRNAs, elucidating functional significance HNSCC. In addition, we delve into clinical implications considering potential biomarkers or targets for diagnosis, prognosis, applications The discussion extends exploring future challenges translation emphasizing need further research.
Language: Английский
Citations
1
Exploration of Targeted Anti-tumor Therapy, Journal Year: 2024, Volume and Issue: 5(4), P. 841 - 876
Published: July 22, 2024
Recently, new data have been added to the interaction between non-coding RNAs (ncRNAs) and epigenetic machinery. Epigenetics includes enzymes involved in DNA methylation, histone modifications, RNA mechanisms underlying chromatin structure, repressive states, active states operating transcription. The main focus is on long ncRNAs (lncRNAs) acting as scaffolds assemble protein complexes. This review does not cover RNA's role sponging microRNAs, or decoy functions. Several lncRNAs were shown regulate activation repression by interacting with Polycomb complexes mixed-lineage leukemia (MLL) activating Various groups reported enhancer of zeste homolog 2 (EZH2) interactions regulatory RNAs. Knowledge function these opens perspective develop therapeutics for cancer treatment. Lastly, interplay epitranscriptomic modifications cancers paves way targets therapy. approach inhibit epitrascriptomics-regulated may bring compounds therapeuticals various types cancer.
Language: Английский
Citations
1
Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 18
Published: Nov. 18, 2024
Neurodegenerative diseases (NDDs) mostly occur in older demographics. With the average lifespan increasing over time, NDDs are becoming one of major adverse factors affecting human health and quality life. Currently, there no specific diagnostic methods for they usually diagnosed based on nonspecific clinical symptoms occasionally by biomarkers, such as β -amyloid (Aβ) Alzheimer’s disease (AD) a-synuclein ( α -syn) Parkinson’s disease, etc. However, it is too late most treatment to startr when aforementioned criteria become detectable. Circular RNAs (circRNAs) a type single-stranded, covalently closed, non-coding that lack 5′ cap structure 3′ terminal poly-A tail. According recent research, circRNAs may play crucial role onset progression some NDDs. These small be potential prognostic markers therapeutic targets these diseases. This review will provide comprehensive overview advancements knowledge functions possible underlying mechanism pathogenesis
Language: Английский
Citations
1
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 19, 2024
Abstract Cardiac arrest (CA) is a common cause of death world wide. The disease has lacks effective treatment. Efforts have been made to elucidate the molecular pathogenesis CA, but mechanisms remain elusive. To identify key genes and pathways in next generation sequencing (NGS) GSE200117 dataset was downloaded from Gene Expression Omnibus (GEO) database. DESeq2 tool used recognize differentially expressed (DEGs). ontology (GO) REACTOME pathway enrichment analyses were performed analyze DEGs associated signal g:Profiler IID database construct protein-protein interaction (PPI) network, modules analysis using Cytoscape. A miRNA-hub gene regulatory network TF-hub then constructed screen miRNAs, TFs hub by miRNet NetworkAnalyst Cityscape software. Receiver operating characteristic curve (ROC) verified genes. In total, 844 identified, comprising 414 up regulated 430 down GO indicated that for CA mainly enriched organonitrogen compound metabolic process, response stimulus, translation immune system. Ten (up-regulated: HSPA8, HOXA1, INCA1 TP53; down-regulated: HSPB1, LMNA, SNCA, ADAMTSL4 PDLIM7) screened. We also predicted miRNAs (hsa-mir-1914-5p hsa-mir-598-3p) (JUN PRRX2) targeting This study uses series bioinformatics technologies obtain hug genes, TFs, related CA. These results provide us with new ideas finding biomarkers treatment methods
Language: Английский
Citations
0
Epigenetics Insights, Journal Year: 2024, Volume and Issue: 17(1), P. 0 - 0
Published: Jan. 1, 2024
Language: Английский
Citations
0