Blood RNA transcripts show changes in inflammation and lipid metabolism in Alzheimer's disease and mitochondrial function in mild cognitive impairment DOI Creative Commons
Jun‐ichi Iga, Yuta Yoshino,

Tomoki Ozaki

et al.

Journal of Alzheimer s Disease Reports, Journal Year: 2024, Volume and Issue: 8(1), P. 1690 - 1703

Published: March 1, 2024

Abnormal immunity in the periphery has been reported pathogenesis of Alzheimer's disease (AD). In this study, blood transcriptome analyses patients with AD, those mild cognitive impairment (MCI) due to and heathy controls were performed elucidate immune-related pathophysiology. The sample included 63 participants from a complete enumeration study elderly people Nakayama town (the Study), who over 65 years age, diagnosed as (1) healthy (N = 21, mean age: 83.8 years), (2) having MCI AD 20, 82.6 or (3) 84.2 years). Every participant underwent tests, magnetic resonance imaging, questionnaires about lifestyle function. With analysis, differential gene expressions three groups evaluated by ontology, pathway enrichment, ingenuity analyses, quantitative real-time PCR was performed. Neutrophil extracellular trap signaling increased, lipid metabolism (FXR/RXR activation, triacylglycerol degradation) decreased whereas showed protective responses via neutrophil mitochondrial functions such upregulation sirtuin downregulation oxidative stress. Based on these findings consistent other published studies, immune cells appear have important roles may be useful biomarker for diagnosis monitoring AD.

Language: Английский

Unveiling the impact of aging on BBB and Alzheimer's disease: Factors and therapeutic implications DOI
Niraj Kumar Jha, Niraj Kumar Jha, Mohana Vamsi Nuli

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 98, P. 102224 - 102224

Published: Feb. 10, 2024

Language: Английский

Citations

14
Positive impact of DPP-4 or SGLT2 inhibitors on mild cognitive impairment in type 2 diabetes patients on metformin therapy: A metabolomic mechanistic insight DOI Open Access

Shams Tarek Osman,

Waziha Purba,

Oluwatosin Daramola

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 182, P. 117771 - 117771

Published: Dec. 21, 2024

Language: Английский

Citations

1
A Population Pharmacokinetic Study to Compare a Novel Empagliflozin L-Proline Formulation with Its Conventional Formulation in Healthy Subjects DOI Creative Commons
Xu Jiang, Kyung‐Sang Yu,

Dong Hyuk Nam

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(4), P. 522 - 522

Published: April 18, 2024

Empagliflozin is a sodium–glucose cotransporter 2 (SGLT2) inhibitor that commonly used for the treatment of type diabetes mellitus (T2DM). CKD-370 was newly developed as cocrystal formulation empagliflozin with co-former L-proline, which has been confirmed to be bioequivalent in South Korea. This study aimed quantify differences absorption phase and pharmacokinetic (PK) parameters two formulations healthy subjects by using population PK analysis. The plasma concentration data were obtained from randomized, open-label, crossover, 1 clinical studies Korean after single-dose administration. A model constructed nonlinear mixed-effects (NLME) approach (Monolix Suite 2021R1). Interindividual variability (IIV) interoccasion (IOV) investigated. final evaluated goodness-of-fit (GOF) diagnostic plots, visual predictive checks (VPCs), prediction errors, bootstrapping. adequately described two-compartment combined transit compartment first-order elimination. Log-transformed body weight significantly influenced systemic clearance (CL) volume distribution peripheral (V2) empagliflozin. GOF VPCs, bootstrapping suggested proposed adequate robust, good precision at different dose strengths. form did not affect drug, affected treatments.

Language: Английский

Citations

0
Blood RNA transcripts show changes in inflammation and lipid metabolism in Alzheimer's disease and mitochondrial function in mild cognitive impairment DOI Creative Commons
Jun‐ichi Iga, Yuta Yoshino,

Tomoki Ozaki

et al.

Journal of Alzheimer s Disease Reports, Journal Year: 2024, Volume and Issue: 8(1), P. 1690 - 1703

Published: March 1, 2024

Abnormal immunity in the periphery has been reported pathogenesis of Alzheimer's disease (AD). In this study, blood transcriptome analyses patients with AD, those mild cognitive impairment (MCI) due to and heathy controls were performed elucidate immune-related pathophysiology. The sample included 63 participants from a complete enumeration study elderly people Nakayama town (the Study), who over 65 years age, diagnosed as (1) healthy (N = 21, mean age: 83.8 years), (2) having MCI AD 20, 82.6 or (3) 84.2 years). Every participant underwent tests, magnetic resonance imaging, questionnaires about lifestyle function. With analysis, differential gene expressions three groups evaluated by ontology, pathway enrichment, ingenuity analyses, quantitative real-time PCR was performed. Neutrophil extracellular trap signaling increased, lipid metabolism (FXR/RXR activation, triacylglycerol degradation) decreased whereas showed protective responses via neutrophil mitochondrial functions such upregulation sirtuin downregulation oxidative stress. Based on these findings consistent other published studies, immune cells appear have important roles may be useful biomarker for diagnosis monitoring AD.

Language: Английский

Citations

0