A neurometabolic mechanism involving dmPFC/dACC lactate in physical effort-based decision-making DOI Creative Commons
Nicolas Clairis,

Arthur Barakat,

Jules Brochard

et al.

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 30, 2024

Motivation levels vary across individuals, yet the underlying mechanisms driving these differences remain elusive. The dorsomedial prefrontal cortex/dorsal anterior cingulate cortex (dmPFC/dACC) and insula (aIns) play crucial roles in effort-based decision-making. Here, we investigate influence of lactate, a key metabolite involved energy metabolism signaling, on decisions involving both physical mental effort, as well its effects neural activation. Using proton magnetic resonance spectroscopy functional MRI 63 participants, find that higher lactate dmPFC/dACC are associated with reduced motivation for relationship mediated by activity within this region. Additionally, plasma correlate, suggesting systemic brain metabolism. Supported path analysis, our results highlight lactate's role modulator activity, hinting at neurometabolic mechanism integrates peripheral central metabolic states function

Language: Английский

Microglia lactylation in relation to central nervous system diseases DOI Creative Commons
Hui Yang,

Nan Mo,

Le Tong

et al.

Neural Regeneration Research, Journal Year: 2024, Volume and Issue: 20(1), P. 29 - 40

Published: April 3, 2024

The development of neurodegenerative diseases is closely related to the disruption central nervous system homeostasis. Microglia, as innate immune cells, play important roles in maintenance homeostasis, injury response, and diseases. Lactate has been considered a metabolic waste product, but recent studies are revealing ever more physiological functions lactate. Lactylation an pathway lactate function involved glycolysis-related functions, macrophage polarization, neuromodulation, angiogenesis also implicated various This review provides overview homeostatic regulatory processes microglia lactylation, histone versus non-histone therapeutic approaches targeting Finally, we summarize current research on lactylation A deeper understanding mechanisms will provide options for treatment

Language: Английский

Citations

10
Myokines and the Brain: A Novel Neuromuscular Endocrine Loop DOI

Wilfredo López-Ojeda,

Robin A. Hurley

Journal of Neuropsychiatry, Journal Year: 2025, Volume and Issue: 37(1), P. A4 - 4

Published: Jan. 1, 2025

Language: Английский

Citations

0
Lactylation and Central Nervous System Diseases DOI Creative Commons
Ye Chen, Dongqiong Xiao, Xihong Li

et al.

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(3), P. 294 - 294

Published: March 11, 2025

As the final product of glycolysis, lactate serves as an energy substrate, metabolite, and signaling molecule in various diseases mediates lactylation, epigenetic modification that occurs under both physiological pathological conditions. Lactylation is a crucial mechanism by which exerts its functions, participating vital biological activities such glycolysis-related cellular macrophage polarization, nervous system regulation. links metabolic regulation to central (CNS) diseases, traumatic brain injury, Alzheimer’s disease, acute ischemic stroke, schizophrenia, revealing diverse functions lactylation CNS. In future, further exploration lactylation-associated enzymes proteins needed develop specific inhibitors or activators, could provide new tools strategies for treatment CNS diseases.

Language: Английский

Citations

0
Lactylation in CNS disorders: mechanisms, cellular function, and disease relevance DOI Creative Commons

Jiaxin Tian,

Tongyu Zhang, Ruidan Zhang

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: March 28, 2025

Lactate, as a metabolic product or energy substrate, participates in various neurological processes within the physiological and pathological frameworks of central nervous system (CNS). The groundbreaking application multi-omics integration technologies has unveiled novel role for lactate: lactylation, unique post-translational modification (PTM) that covalently attaches lactate groups to lysine residues on proteins. This process precisely regulates protein function gene expression, profoundly influencing progression diseases. lactylation is meticulously regulated by variety key enzymes pathways, forming dynamic intricate network. In this review, we summarize involved specifically "Writers," "Erasers," "Readers." Furthermore, systematically categorize observed cell types CNS investigate its multifaceted roles processes, including neurodegenerative diseases, brain tumors, injuries. By consolidating latest research findings field, our review aims highlight significance these discoveries future explore their potential translational applications.

Language: Английский

Citations

0
Targeting Lactate: An Emerging Strategy for Macrophage Regulation in Chronic Inflammation and Cancer DOI Creative Commons

Rong Jiang,

Wenjing Ren,

Liying Wang

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(10), P. 1202 - 1202

Published: Sept. 24, 2024

Lactate accumulation and macrophage infiltration are pivotal features of both chronic inflammation cancer. Lactate, once regarded merely as an aftereffect glucose metabolism, is now gaining recognition for its burgeoning spectrum biological roles immunomodulatory significance. Recent studies have evidenced that macrophages display divergent immunophenotypes in different diseases, which play a role disease management by modulating polarization within the microenvironment. The specific patterns high-lactate environment their contribution to progression cancer remain contentious. This review presents current evidence on crosstalk lactate Additionally, we provide in-depth exploration yet enigmatic mechanisms through orchestrates pathogenesis, thereby offering novel perspectives development targeted therapeutic interventions

Language: Английский

Citations

3
Lactylation: A Novel Post-Translational Modification with Clinical Implications in CNS Diseases DOI Open Access
Jun‐Yan Liu, Fengyan Zhao, Yi Qu

et al.

Published: July 19, 2024

Lactate, an important metabolic product, provides energy to neural cells during depletion or high demand and acts as a signaling molecule in the central nervous system. Recent studies revealed that lactate-mediated protein lactylation regulates gene transcription influences cell fate, processes, inflammation, immune responses. This review comprehensively examines regulatory roles mechanisms of neurodevelopment, neuropsychiatric disorders, brain tumors, cerebrovascular diseases. analysis indicates has multifaceted effects on system function pathology, particularly hypoxia-induced damage. Highlighting its potential novel therapeutic target, may play significant role treating neurological By summarizing current findings, this aims provide insights guide future research clinical strategies for disorders.

Language: Английский

Citations

2
Associations between plasma markers and symptoms of anxiety and depression in patients with breast cancer DOI Creative Commons
Yibo He,

Shangping Cheng,

Lingrong Yang

et al.

BMC Psychiatry, Journal Year: 2024, Volume and Issue: 24(1)

Published: Oct. 11, 2024

Among patients with solid tumors, those breast cancer (BC) experience the most severe psychological issues, exhibiting a high global prevalence of depression that negatively impacts prognosis. Depression can be easily missed, and clinical markers for its diagnosis are lacking. Therefore, this study in order to investigate diagnostic BC anxiety explore specific changes metabolism. Thirty-eight thirty-six matched healthy controls were included study. The symptoms participants evaluated by 17-item Hamilton Scale (HAMD-17) Anxiety (HAMA). Plasma levels glial fibrillary acidic protein (GFAP) lipocalin-2 (LCN2) using enzyme linked immunosorbent assay, plasma lactate metabolic characteristics analyzed. This revealed GFAP LCN2 may good or also marker anxiety. In addition, metabolism preliminarily explored.

Language: Английский

Citations

2
A neurometabolic mechanism involving dmPFC/dACC lactate in physical effort-based decision-making DOI Creative Commons
Nicolas Clairis, Ahmed Barakat, Jules Brochard

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 4, 2024

Abstract Motivation levels vary across individuals, yet the underlying mechanisms driving these differences remain elusive. The dorsomedial prefrontal cortex/dorsal anterior cingulate cortex (dmPFC/dACC) and insula (aIns) play crucial roles in effort-based decision-making. Here, we investigate influence of lactate, a key metabolite involved energy metabolism signaling, on decisions involving both physical mental effort, as well its effects neural activation. Using proton magnetic resonance spectroscopy functional MRI 63 participants, find that higher lactate dmPFC/dACC are associated with reduced motivation for relationship mediated by activity within this region. Additionally, plasma correlate, suggesting systemic brain metabolism. Supported path analysis, our results highlight lactate’s role modulator activity, hinting at neurometabolic mechanism integrates peripheral central metabolic states function

Language: Английский

Citations

1
Resting-State EEG Alterations of Practice-Related Spectral Activity and Connectivity Patterns in Depression DOI Creative Commons
Elisa Tatti,

Alessandra Cinti,

Anna Serbina

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(9), P. 2054 - 2054

Published: Sept. 10, 2024

Depression presents with altered energy regulation and neural plasticity. Previous electroencephalography (EEG) studies showed that practice in learning tasks increases power beta range (13-30 Hz) healthy subjects but not those impaired Here, we ascertain whether depression alterations of spectral activity connectivity before after a task.

Language: Английский

Citations

1
Lactylation: A Novel Post-Translational Modification with Clinical Implications in CNS Diseases DOI Creative Commons
Junyan Liu, Fengyan Zhao, Yi Qu

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(9), P. 1175 - 1175

Published: Sept. 19, 2024

Lactate, an important metabolic product, provides energy to neural cells during depletion or high demand and acts as a signaling molecule in the central nervous system. Recent studies revealed that lactate-mediated protein lactylation regulates gene transcription influences cell fate, processes, inflammation, immune responses. This review comprehensively examines regulatory roles mechanisms of neurodevelopment, neuropsychiatric disorders, brain tumors, cerebrovascular diseases. analysis indicates has multifaceted effects on system function pathology, particularly hypoxia-induced damage. Highlighting its potential novel therapeutic target, may play significant role treating neurological By summarizing current findings, this aims provide insights guide future research clinical strategies for disorders.

Language: Английский

Citations

1