The Effect of 14-Day Consumption of Hydrogen-Rich Water Alleviates Fatigue but Does Not Ameliorate Dyspnea in Long-COVID Patients: A Pilot, Single-Blind, and Randomized, Controlled Trial

Nutrients, Journal Year: 2024, Volume and Issue: 16(10), P. 1529 - 1529

Published: May 19, 2024

(1) Background: Hydrogen (H2) may be a potential therapeutic agent for managing Long COVID symptoms due to its antioxidant and anti-inflammatory properties. However, more scientific literature is needed describe the effects of H2 administration on treating symptoms. A study aimed investigate impact hydrogen-rich water (HRW) fatigue dyspnea Long-COVID patients 14 consecutive days. (2) Methods: In this randomized, single-blind, placebo-controlled study, 55 participants were recruited, 23 them excluded. total 32 eligible randomized into group (n = 16) placebo (PW) in which they instructed consume or days, respectively. The completed Fatigue Severity Scale (FSS), Six-Minute Walk Test (6MWT), 30 s Chair Stand (30s-CST), Modified Medical Research Council Dyspnea Rating (mMRC), Pittsburgh Sleep Quality Index (PSQI), depression anxiety stress scale (DASS-21) before after intervention. linear mixed-effects model was used analyze HRW. Cohen’s d values assess effect size when significance observed. mean change with 95% confidence intervals (95% CI) also reported. (3) Results: HRW lowering FSS scores (p 0.046, [95% CI −20.607, −0.198, 0.696] improving distance 6WMT < 0.001, 41.972, 61.891], 1.010), time 30s-CST 0.002, 1.570, 6.314], 1.190), PSQI 0.012, −5.169, 0.742], 1.274) compared PW significantly moderate size, while there no significant difference mMRC score 0.556) DASS-21 > 0.143). (4) Conclusions: This demonstrates that might an effective strategy alleviating cardiorespiratory endurance, musculoskeletal function, sleep quality. Still, it does not ameliorate among patients.

Language: Английский

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Theoretical evaluation of the biological activity of hydrogen

Medical Gas Research, Journal Year: 2025, Volume and Issue: 15(2), P. 266 - 275

Published: Jan. 18, 2025

Hydrogen (H 2 ), the simplest and most ubiquitous molecule in universe, has garnered significant scientific interest over past two decades because of its potential as an effective antioxidant anti-inflammatory agent. Traditionally considered inert, H is now being re-evaluated for unique bioactive properties. selectively neutralizes reactive oxygen nitrogen species, mitigating oxidative stress without disrupting essential cellular functions. This review therefore aims to provide a theoretical evaluation biological activity , focusing on pharmacokinetics, including absorption, distribution, retention within systems. The pharmacokinetic profile crucial understanding therapeutic applications. interaction with protein pockets particular interest, these sites may serve reservoirs or active influencing time. Additionally, impact signaling pathways, those regulating glucose metabolism responses, will be explored, offering insights into modulator metabolic redox homeostasis. Finally, interactions ferromagnetic molecules environments, well effects mechanisms, add another layer complexity role . By synthesizing current research, this seeks elucidate underlying mechanisms by which exert while also identifying critical areas further investigation. Understanding aspects fully characterizing pharmacodynamic assessing clinical treatment stress–related disorders.

Language: Английский

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Prospects of Hydrogen Medicine Based on Its Protective Effects on Mitochondrial Function

Advances in biochemistry in health and disease, Journal Year: 2024, Volume and Issue: unknown, P. 39 - 54

Published: Jan. 1, 2024

Language: Английский

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Патогенез синдрома хронической усталости

International journal of medicine and psychology., Journal Year: 2024, Volume and Issue: 7(8), P. 50 - 61

Published: Dec. 28, 2024

синдром хронической усталости (далее – СХУ) представляет собой сложное и недостаточно изученное заболевание, характеризующееся персистирующей усталостью, не проходящей после отдыха, широким спектром сопутствующих симптомов. Несмотря на интенсивные исследования, этиология патогенез СХУ остаются во многом неясными, что существенно затрудняет диагностику лечение. В данной статье представлен обзор современных представлений о ключевых звеньях патогенеза СХУ, включая иммунную дисфункцию, нейроэндокринные нарушения, митохондриальную недостаточность, окислительный стресс, нарушения сна когнитивные расстройства. Обсуждаются потенциальные биомаркеры терапевтические мишени для каждого из этих патогенетических компонентов, а также подчеркивается необходимость разработки персонализированных терапевтических стратегий основе анализа индивидуальных особенностей течения заболевания. Подчеркивается важность дальнейших междисциплинарных исследований расшифровки механизмов создания эффективных методов его диагностики лечения. chronic fatigue syndrome (CFS) is a complex and poorly understood disorder characterized by persistent not alleviated rest wide range of associated symptoms. Despite intensive research efforts, the etiology pathogenesis CFS remain largely unclear, which significantly complicates its diagnosis treatment. This article provides an overview current concepts regarding key pathogenetic components CFS, including immune dysfunction, neuroendocrine disturbances, mitochondrial insufficiency, oxidative stress, sleep disorders, cognitive impairment. Potential biomarkers therapeutic targets for each these are discussed, need personalized strategies based on individual disease course analysis emphasized. The importance further interdisciplinary to elucidate mechanisms develop effective methods treatment highlighted.

Language: Русский

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