Impact of a high inspired oxygen fraction on oxidative stress in pediatric patients: reassuring results based on a randomized trial DOI Creative Commons
Ting Li, Ying Han, Xinliang Zhang

et al.

Medical Gas Research, Journal Year: 2025, Volume and Issue: 15(2), P. 332 - 338

Published: Jan. 18, 2025

High-concentration oxygen inhalation is the primary intervention to prevent perioperative hypoxemia. However, there are concerns that this may induce an imbalance in oxidation‒reduction processes, particularly pediatric patients with compromised antioxidant defenses. This study aimed evaluate impact of varying intraoperative concentrations on oxidative stress children by analyzing plasma biomarkers, oxygenation indices, and duration surgery inhalation. Forty-five scheduled for laparoscopic pyeloplasty under general anesthesia were randomly assigned three groups, each receiving different fractions inspired during surgery: 30%, 50%, or 80%. The outcome was concentration markers, other measurements included surgical exposure. Thirty-five completed study, 11 low group, 12 medium group high group. levels superoxide dismutase at immediately post-tracheal intubation, hydrogen peroxide 1 hour post-intubation, 8-isoprostane post-surgical procedure significantly higher than S100B those intubation post-intubation within Therefore, we conclude inhaling a anesthesia, less 3 hours, does not increase patients. registered Chinese Clinical Trial Registry (registration No. ChiCTR2400083143).

Language: Английский

Impact of a high inspired oxygen fraction on oxidative stress in pediatric patients: reassuring results based on a randomized trial DOI Creative Commons
Ting Li, Ying Han, Xinliang Zhang

et al.

Medical Gas Research, Journal Year: 2025, Volume and Issue: 15(2), P. 332 - 338

Published: Jan. 18, 2025

High-concentration oxygen inhalation is the primary intervention to prevent perioperative hypoxemia. However, there are concerns that this may induce an imbalance in oxidation‒reduction processes, particularly pediatric patients with compromised antioxidant defenses. This study aimed evaluate impact of varying intraoperative concentrations on oxidative stress children by analyzing plasma biomarkers, oxygenation indices, and duration surgery inhalation. Forty-five scheduled for laparoscopic pyeloplasty under general anesthesia were randomly assigned three groups, each receiving different fractions inspired during surgery: 30%, 50%, or 80%. The outcome was concentration markers, other measurements included surgical exposure. Thirty-five completed study, 11 low group, 12 medium group high group. levels superoxide dismutase at immediately post-tracheal intubation, hydrogen peroxide 1 hour post-intubation, 8-isoprostane post-surgical procedure significantly higher than S100B those intubation post-intubation within Therefore, we conclude inhaling a anesthesia, less 3 hours, does not increase patients. registered Chinese Clinical Trial Registry (registration No. ChiCTR2400083143).

Language: Английский

Citations

1