Phytochemical Importance of Medicinal Plants as Potential Sources Against Neurodegenerative Diseases DOI
Vibha Pandey, Debasis Chakrabarty

Published: Jan. 1, 2024

Language: Английский

The Role of Calcium and Iron Homeostasis in Parkinson’s Disease DOI Creative Commons
Ji Wang, Jindong Zhao,

Kunying Zhao

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(1), P. 88 - 88

Published: Jan. 17, 2024

Calcium and iron are essential elements that regulate many important processes of eukaryotic cells. Failure to maintain homeostasis calcium causes cell dysfunction or even death. PD (Parkinson’s disease) is the second most common neurological disorder in humans, for which there currently no viable treatment options effective strategies cure delay progression. Pathological hallmarks PD, such as dopaminergic neuronal death intracellular α-synuclein deposition, closely involved perturbations accumulation. Here, we summarize mechanisms by Ca2+ signaling influences promotes progression main ferroptosis Parkinson’s disease. Understanding imbalances contribute this disease critical developing treatments combat devastating disorder.

Language: Английский

Citations

12
Ferroptosis in senescence and age-related diseases: pathogenic mechanisms and potential intervention targets DOI
Chang Liu, Jie Pan,

Qi Bao

et al.

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: Feb. 17, 2025

Language: Английский

Citations

1
Baohuoside I suppresses the NLRP3 inflammasome activation via targeting GPER to fight against Parkinson's disease DOI
Yu Gu,

Zifan Hu,

Danwen Zheng

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 126, P. 155435 - 155435

Published: Feb. 13, 2024

Language: Английский

Citations

6
Icariside II Alleviates Chondrocyte Inflammatory Injury by Inhibiting the TNIP2/NF-κB Pathway DOI

J Mei,

Hongkui Ke,

Junsong Zhu

et al.

Cell Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Language: Английский

Citations

0
Navigating the Complexities of Neuronal Signaling and Targets in Neurological Disorders: From Pathology to Therapeutics DOI

Divya Choudhary,

Muhammad Imran Khan, Zuber Khan

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177417 - 177417

Published: Feb. 1, 2025

Language: Английский

Citations

0
Targeting Ferroptosis: Acteoside as a Neuroprotective Agent in Salsolinol-Induced Parkinson’s Disease Models DOI Creative Commons
Hongquan Wang, Shuang Wu, Li Qiang

et al.

Frontiers in Bioscience-Landmark, Journal Year: 2025, Volume and Issue: 30(2)

Published: Feb. 14, 2025

Background: Salsolinol (SAL) is a dopamine metabolite and endogenous neurotoxin that exerts neurotoxicity to dopaminergic neurons involved in the genesis of Parkinson’s disease (PD). However, machinery underlying SAL-induced PD still being elucidated. Methods: In present study, we first used RNA-seq KEGG analysis examine differentially expressed genes SAL-challenged SH-SY5Y cells. animal models were established treated with acteoside. Cell viability assays, lipid peroxidation assessments (malondialdehyde [MDA] 4-Hydroxynonenal [4-HNE]), immunoblot, transmission electron microscopy confirm acteoside-mediated inhibition ferroptosis its neuroprotective effect on (DA) neurons. Results: We found ferroptosis-related pathway was enriched by SAL. SAL inducing through upregulating long-chain acyl-CoA synthetase family member 4 (ACSL4) cells, which neurotoxic reversed inhibitors ferrostatin-1 (Fer-1) deferoxamine (DFO). Acteoside, phenylethanoid glycoside plant origin effect, attenuates inhibiting vitro vivo downregulating ACSL4. Conclusions: The study revealed novel molecular mechanism via induction PD, uncovered new pharmacological against ferroptosis. This highlights as potential therapeutic target PD.

Language: Английский

Citations

0
Natural flavonoids from herbs and nutraceuticals as ferroptosis inhibitors in central nervous system diseases: current preclinical evidence and future perspectives DOI Creative Commons

Qiuhe Li,

Xiaohang Yang, Tiegang Li

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 24, 2025

Flavonoids are a class of important polyphenolic compounds, renowned for their antioxidant properties. However, recent studies have uncovered an additional function these natural flavonoids: ability to inhibit ferroptosis. Ferroptosis is key mechanism driving cell death in central nervous system (CNS) diseases, including both acute injuries and chronic neurodegenerative disorders, characterized by iron overload-induced lipid peroxidation dysfunction the defense system. This review discusses therapeutic potential flavonoids from herbs nutraceuticals as ferroptosis inhibitors CNS focusing on molecular mechanisms, summarizing findings preclinical animal models, providing insights clinical translation. We specifically highlight such Baicalin, Baicalein, Chrysin, Vitexin, Galangin, Quercetin, Isoquercetin, Eriodictyol, Proanthocyanidin, (−)-epigallocatechin-3-gallate, Dihydromyricetin, Soybean Isoflavones, Calycosin, Icariside II, Safflower Yellow, which shown promising results models injuries, ischemic stroke, cerebral ischemia-reperfusion injury, intracerebral hemorrhage, subarachnoid traumatic brain spinal cord injury. Among these, Baicalin its precursor Baicalein stand out due extensive research favorable outcomes injury models. Mechanistically, not only regulate Nrf2/ARE pathway activate GPX4/GSH-related pathways but also modulate metabolism proteins, thereby alleviating overload inhibiting While show promise especially settings, further needed evaluate efficacy, safety, pharmacokinetics, blood-brain barrier penetration application.

Language: Английский

Citations

0
Phytochemical Importance of Medicinal Plants as Potential Sources Against Neurodegenerative Diseases DOI
Vibha Pandey, Debasis Chakrabarty

Published: Jan. 1, 2024

Language: Английский

Citations

0