Effect of Topical Silver Nanoparticle Formulation on Wound Bacteria Clearance and Healing in Patients With Infected Wounds Compared to Standard Topical Antibiotic Application: A Randomized Open-Label Parallel Clinical Trial

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: May 18, 2024

Background: Infected wounds pose a special challenge for management, with an increased risk of wound chronicity, systemic infection, and the emergence antibiotic resistance. Silver nanoparticles have multimodal effects on bacteria clearance healing. This study aimed to document efficacy topical silver nanoparticle-based cream healing in infected compared Mupirocin. Methods: open-label parallel randomized clinical trial allocated 86 participants (culture-positive) into Kadermin, arm (n=43) Mupirocin documented swab culture day 5 at 28, along periodic status using Bates-Jensen Wound Assessment Tool. Patients received oral/systemic antibiotics other medications underlying diseases. The intention-to-treat principle was adopted data analysis chi-square Student t tests differences between groups according variable characteristics. Results: All completed follow-up. On 5, observed 86% 65.1% Kadermin arms, respectively (p=0.023). At complete 81.4% 37.2% (p≤0.001). No local or adverse event reaction any participants. Conclusion: cream, has better achieving faster may relevance its use as antibiotic-sparing agent management.

Language: Английский

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Prevalence and risk factors associated with diabetic foot ulcer in India: a systematic review and meta-analysis

International Journal of Diabetes in Developing Countries, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 10, 2024

Language: Английский

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Development and validation of an interprofessional collaborative educational module on the self-management of foot for individuals with type II diabetes mellitus in India

F1000Research, Journal Year: 2025, Volume and Issue: 13, P. 386 - 386

Published: Jan. 10, 2025

Background Insufficient awareness of foot self-care among diabetic individuals results in ulcers especially the Indian population considering its varied ethnicity and lifestyle practices. The management diabetes therefore demands a well-coordinated approach that involves multiple healthcare providers (HCPs). present study aims to develop validate an interprofessional collaborative (IPC) educational program involving HCPs efficiently oversee instruct public on appropriate strategies for self-managing health population. Methods research group worked creating module titled ‘An Interprofessional Collaborative Educational Module Self-Management Foot Individuals with Type II Diabetes Mellitus.’ objective this was promote adoption proper practices type 2 mellitus. A panel 13 experts participated two-stage validation process using Delphi method assess resources. Subsequently, tested 30 participants, i.e., diabetes, efficacy evaluated through conversation analysis in-depth interviews. Results three-month-long included three sessions • 1: implications 2: Diabetic self-management 3: education care mode content delivery via Whatsapp, resources, form pamphlets, flowcharts, handouts, case-based cartoons, videos including foot, risks, self-management, were shared regularly. All participating consensually validated Analysis interviews revealed immensely benefitted participants helped them improve their knowledge diabetes. Conclusions highlights importance developing validating IPC modules tailored care. It can aid enhancing adherence By promoting approaches, these resources contribute better preventive practices, potentially reducing risk complications like amputations diabetes.

Language: Английский

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Prevalence and predictors of infected diabetic foot ulcers (DFU) and DFU-related osteomyelitis amongst industrial workers wearing occupational safety footwear

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 20, 2025

Language: Английский

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Uncovering the Role of Tertiary Lymphoid Organs in the Inflammatory Landscape: A Novel Immunophenotype of Diabetic Foot Ulcers

Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(7)

Published: March 30, 2025

ABSTRACT Diabetes foot ulcers (DFU) are the most common injuries leading to lower extremity amputation. Our study aimed provide first representative analysis highlighting vital role of Tertiary Lymphoid Organs (TLO) inflammatory landscape in diabetic ulcers. The explores mechanisms TLO formation and disease‐specific roles TLOs regulating peripheral immune responses. Additionally, comprehensive clinical data from DFU cases, focused on pathophysiology systemic immune‐inflammation landscape, is documented, aiming identify risk factors contributing development DFUs. experimental results showed very significant differences were observed among IL‐17 IFN‐γ cytokine levels between vs. Control NIDFU (Non‐Infectious Diabetic Foot Ulcers) groups, while minimal IL‐6 TNF‐α levels. Immunohistochemistry staining or Immunophenotyping patient‐derived wound samples for stratification remarkable DFU, NIDFU, control groups both CD3 + T Cells CD20 B cells. Overall, our findings highlight perspective its prudent inflammatory‐immune study‐related might be one important mechanisms, effective unveil a valuable treatment modality DFU‐complications.

Language: Английский

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Epidemiological, clinical, biological, therapeutic and evolutionary profiles of infected diabetic foot hospitalized in the endocrinology department of Joseph Raseta Befelatanana University Hospital in Antananarivo, Madagascar

International Journal of Research in Medical Sciences, Journal Year: 2025, Volume and Issue: 13(5), P. 1900 - 1907

Published: April 29, 2025

Background: Diabetic foot infection is a serious risk of amputation and death. Our study aims to describe the epidemiological, clinical, biological, therapeutic evolutionary profiles patients hospitalized for infected diabetic foot. Methods: This descriptive cross-sectional conducted in Endocrinology department Joseph Raseta Befelatanana University Hospital, Antananarivo over period 4 years. The diagnosis was made according criteria French-Speaking Society Infectious Pathology. We included all who had undergone bacteriological examination with antibiogram their lesion. Results: Fifty were retained, giving hospital prevalence 2.84%. Their mean age 55.50±9.63 years, sex ratio 0.72 duration diabetes 6.87±6.13 majority lesions post-traumatic (28%). length stay 42.82±35.26 days. Infections classified as stage 72% patients. main isolated bacteria Staphylococcus aureus (54.69%), which 83% sensitive Amoxicillin-Clavulanic Acid. Seventy percent multidrug-resistant bacteria. rate 30% mortality 2%. Conclusions: Therapeutic education on podiatric care must be optimized. Multi-disciplinarity essential management. Amoxicillin-clavulanic acid should preferred probabilistic antibiotic therapy our country where often lacking.

Language: Английский

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Vitamin D binding protein gene polymorphisms in Ugandan tuberculosis patients and household contacts: A pilot study

F1000Research, Journal Year: 2025, Volume and Issue: 14, P. 154 - 154

Published: Feb. 4, 2025

Background Insufficient awareness of foot self-care among diabetic individuals results in ulcers especially the Indian population considering its varied ethnicity and lifestyle practices. The management diabetes therefore demands a well-coordinated approach that involves multiple healthcare providers (HCPs). present study aims to develop validate an interprofessional collaborative (IPC) educational program involving HCPs efficiently oversee instruct public on appropriate strategies for self-managing health population. Methods research group worked creating module titled ‘An Interprofessional Collaborative Educational Module Self-Management Foot Individuals with Type II Diabetes Mellitus.’ objective this was promote adoption proper practices type 2 mellitus. A panel 13 experts participated two-stage validation process using Delphi method assess resources. Subsequently, tested 30 participants, i.e., diabetes, efficacy evaluated through conversation analysis in-depth interviews. Results three-month-long included three sessions • 1: implications 2: Diabetic self-management 3: education care mode content delivery via Whatsapp, resources, form pamphlets, flowcharts, handouts, case-based cartoons, videos including foot, risks, self-management, were shared regularly. All participating consensually validated Analysis interviews revealed immensely benefitted participants helped them improve their knowledge diabetes. Conclusions highlights importance developing validating IPC modules tailored care. It can aid enhancing adherence practices.

Language: Английский

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Development and validation of an interprofessional collaborative educational module on the self-management of foot for individuals with type II diabetes mellitus in India

F1000Research, Journal Year: 2025, Volume and Issue: 13, P. 386 - 386

Published: Feb. 4, 2025

Background Insufficient awareness of foot self-care among diabetic individuals results in ulcers especially the Indian population considering its varied ethnicity and lifestyle practices. The management diabetes therefore demands a well-coordinated approach that involves multiple healthcare providers (HCPs). present study aims to develop validate an interprofessional collaborative (IPC) educational program involving HCPs efficiently oversee instruct public on appropriate strategies for self-managing health population. Methods research group worked creating module titled ‘An Interprofessional Collaborative Educational Module Self-Management Foot Individuals with Type II Diabetes Mellitus.’ objective this was promote adoption proper practices type 2 mellitus. A panel 13 experts participated two-stage validation process using Delphi method assess resources. Subsequently, tested 30 participants, i.e., diabetes, efficacy evaluated through conversation analysis in-depth interviews. Results three-month-long included three sessions 1: implications 2: Diabetic self-management 3: education care mode content delivery via Whatsapp, resources, form pamphlets, flowcharts, handouts, case-based cartoons, videos including foot, risks, self-management, were shared regularly. All participating consensually validated Analysis interviews revealed immensely benefitted participants helped them improve their knowledge diabetes. Conclusions highlights importance developing validating IPC modules tailored care. It can aid enhancing adherence practices.

Language: Английский

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Novel Minimally Invasive Proximal Phalanx Osteotomy for Recurrent Plantar Diabetic Foot Ulcers of Hallux: A Case Series Describing a Novel Technique

Journal of Foot and Ankle Surgery (Asia Pacific), Journal Year: 2025, Volume and Issue: 12(2), P. 53 - 58

Published: April 8, 2025

Language: Английский

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Socio-Demographic Risk Factors Associated with Diabetic Foot Ulcer in India: A Case Control Study

Journal of Pharmacy And Bioallied Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

A BSTRACT Background: Diabetic foot ulcers (DFU) are a devastating complication of diabetes mellitus, having significant impact on the quality life patients and indeed putting an enormous burden health care systems, especially in low- middle-income countries like India. Understanding socio-demographic risk factors is, therefore, essential designing successful prevention strategies adapted to Indian population. Methods: The duration was one year, study conducted India 150 cases. Cases consisted with diabetic ulcers, while controls were without consisting 75 cases controls, respectively. Information variables, history, lifestyle collected through structured interviews medical records. Logistic regression analysis used identify independently associated DFU. Results: Low socioeconomic status significantly increased DFU (OR = 3.45, 95% CI: 2.1–5.7), as poor glycemic control (HbA1c >8%) 2.96, 1.9–4.8), living rural area 2.72, 1.8–4.1), lack formal education 2.30, 1.5–3.5). Risk smoking, more than 10 years’ duration, history bad practice. Conclusion: Socioeconomic disparities awareness about contribute Targeted interventions, education, better control, accessible services ultimately needed manage this potentially preventable complication.

Language: Английский

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