Comparative Bioavailability of Omega-3 Polyunsaturated Fatty Acids in Fish Oil and Krill Oil: A Network Meta-Analysis DOI
Thi-Phuong-Thao Pham,

Phuc-Thao-Nguyen Cao,

Thi-Thuy-Duong Le

et al.

SSRN Electronic Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Background and aims: Despite the known health benefits of Omega-3 polyunsaturated fatty acids (PUFAs), comparative bioavailability these nutrients from fish oil (FO) krill (KO) remains inadequately explored. This study addresses gap by evaluating various forms doses PUFAs in FO KO, utilizing a network meta-analysis approach.Methods: The adhered to PRISMA 2015 guidelines. risk bias was evaluated using PEDro scale. incorporated data studies published between 1993 2023, analyzed different assessing daily categorized into three levels based on their DHA+EPA content. Statistical analysis conducted advanced models R software ensure rigorous evaluation bioavailability. PROSPERO ID: CRD42024532536.Results: Out 40 high-quality studies, findings this reveal superior KO compared at equivalent doses. Specifically, above 3000 mg, re-esterified triacylglycerol (100 - 4000 mg) ethyl ester (2000 significantly enhanced levels, DHA EPA, with highest AUC values observed phospholipid/free acid form 1900 emulsion mg). These results were supported robust statistical evidence (Egger's test, p > 0.05), highlighting effectiveness specific formulations optimizing absorption. Conclusion: is first systematically compare across wide range Notably, higher FO, specifically those exceeding such as ranging 100 2900 have shown effectively enhance O3i, DHA, EPA; although focused low mg. Future research should further investigate dose-response relationship oils better inform clinical dietary

Language: Английский

Comparative Bioavailability of Omega-3 Polyunsaturated Fatty Acids in Fish Oil and Krill Oil: A Network Meta-Analysis DOI
Thi-Phuong-Thao Pham,

Phuc-Thao-Nguyen Cao,

Thi-Thuy-Duong Le

et al.

SSRN Electronic Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Background and aims: Despite the known health benefits of Omega-3 polyunsaturated fatty acids (PUFAs), comparative bioavailability these nutrients from fish oil (FO) krill (KO) remains inadequately explored. This study addresses gap by evaluating various forms doses PUFAs in FO KO, utilizing a network meta-analysis approach.Methods: The adhered to PRISMA 2015 guidelines. risk bias was evaluated using PEDro scale. incorporated data studies published between 1993 2023, analyzed different assessing daily categorized into three levels based on their DHA+EPA content. Statistical analysis conducted advanced models R software ensure rigorous evaluation bioavailability. PROSPERO ID: CRD42024532536.Results: Out 40 high-quality studies, findings this reveal superior KO compared at equivalent doses. Specifically, above 3000 mg, re-esterified triacylglycerol (100 - 4000 mg) ethyl ester (2000 significantly enhanced levels, DHA EPA, with highest AUC values observed phospholipid/free acid form 1900 emulsion mg). These results were supported robust statistical evidence (Egger's test, p > 0.05), highlighting effectiveness specific formulations optimizing absorption. Conclusion: is first systematically compare across wide range Notably, higher FO, specifically those exceeding such as ranging 100 2900 have shown effectively enhance O3i, DHA, EPA; although focused low mg. Future research should further investigate dose-response relationship oils better inform clinical dietary

Language: Английский

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