Inhibition of hepatic gluconeogenesis in type 2 diabetes by metformin: complementary role of nitric oxide DOI
Azam Shirinabadi Farahani,

Aryan Farahani,

Khosrow Kashfi

et al.

Medical Gas Research, Journal Year: 2025, Volume and Issue: 15(4), P. 507 - 519

Published: April 29, 2025

Metformin is the first-line treatment for type 2 diabetes mellitus. Type mellitus associated with decreased nitric oxide bioavailability, which has significant metabolic implications, including enhanced insulin secretion and peripheral glucose utilization. Similar to metformin, also inhibits hepatic production, mainly by suppressing gluconeogenesis. This review explores combined effects of metformin on gluconeogenesis proposes potential a hybrid metformin-nitric drug managing Both inhibit through overlapping distinct mechanisms. In gluconeogenesis, mitochondrial oxaloacetate exported cytoplasm via various pathways, malate, direct, aspartate, fumarate pathways. The exportation are complementary; primarily malate pathway, while strongly aspartate Furthermore, effectively blocks from lactate, glycerol, glutamine, whereas alanine-induced Additionally, contributes adenosine monophosphate-activated protein kinase-dependent inhibition induced metformin. use offers mitigate common side effects. For example, lactic acidosis, known effect linked deficiency, oxidative nitrosative stress caused could be counterbalanced metformin’s enhancement glutathione. amplifies -induced activation kinase. conclusion, can benefit patients enhancing decreasing required dose maintaining optimal glycemia, lowering incidence metformin-associated acidosis.

Language: Английский

Nitric oxide: a gas transmitter in healthy and diseased skin DOI
Victoria Zaborova, Е. В. Буданова, Kira Kryuchkova

et al.

Medical Gas Research, Journal Year: 2025, Volume and Issue: 15(4), P. 520 - 528

Published: April 29, 2025

Numerous physiological processes in the human skin are mediated by nitric oxide, a gaseous signalling molecule. Almost every type of cell may produce it is possible to generate oxide without need enzymes. Nitric plays crucial role regulating apoptosis, keratinocyte differentiation and proliferation, protective properties epidermal barrier, structure functions microcirculatory bed. involved immunological inflammatory responses, hair growth regulation, wound healing processes. It mediates ultraviolet-induced such as erythema edema development participates melanogenesis. Furthermore, ability bind reactive oxygen species prevent lipid peroxidation gives antioxidant qualities. This coordinated action on gene expression membrane integrity effectively protects cells from ultraviolet A-induced apoptosis necrosis. can be considered molecule that inhibits cancer photoaging. directly harms microorganisms indirectly activates immune system, exhibiting antibacterial, antiviral, antifungal Notably, effective against antibiotics-resistant bacteria. All aforementioned findings suggest mediator protect function.

Language: Английский

Citations

1
Nanomaterials as medicinal gas sensors described by density functional theory: a comprehensive review DOI Creative Commons

Handriela Hoff de Oliveira Sobrinho,

Renato Eising, Ernesto Osvaldo Wrasse

et al.

Medical Gas Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

Using medical gas detectors offers a promising and non-invasive approach for the early identification of diseases. This technique provides less painful more accessible alternative to traditional diagnostic methods. In development these new detection methods, use nanomaterials as sensors has proven advantageous due their large surface areas, which enhance reactivity sensitivity in identifying volatile compounds. To evaluate behavior when contact with gases, ab initio computational simulations based on density functional theory have shown be effective. literature review presents studies that applied investigate intermolecular interactions between specific nanosystems such toluene, hydrogen sulfide, ammonia, nitric oxide. These yielded results related adsorption dissociation energies, electronic properties, energy gaps, bond lengths, charge transfer, suggesting potential effective detection.

Language: Английский

Citations

0
Therapeutic effect and concomitant toxicity of Hydrargyrum Chloratum Compositum on chronic difficult-to-heal wounds in rats DOI
Yang Yu, Ping Huang, Jingjing Yang

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119749 - 119749

Published: April 1, 2025

Language: Английский

Citations

0
Inhibition of hepatic gluconeogenesis in type 2 diabetes by metformin: complementary role of nitric oxide DOI
Azam Shirinabadi Farahani,

Aryan Farahani,

Khosrow Kashfi

et al.

Medical Gas Research, Journal Year: 2025, Volume and Issue: 15(4), P. 507 - 519

Published: April 29, 2025

Metformin is the first-line treatment for type 2 diabetes mellitus. Type mellitus associated with decreased nitric oxide bioavailability, which has significant metabolic implications, including enhanced insulin secretion and peripheral glucose utilization. Similar to metformin, also inhibits hepatic production, mainly by suppressing gluconeogenesis. This review explores combined effects of metformin on gluconeogenesis proposes potential a hybrid metformin-nitric drug managing Both inhibit through overlapping distinct mechanisms. In gluconeogenesis, mitochondrial oxaloacetate exported cytoplasm via various pathways, malate, direct, aspartate, fumarate pathways. The exportation are complementary; primarily malate pathway, while strongly aspartate Furthermore, effectively blocks from lactate, glycerol, glutamine, whereas alanine-induced Additionally, contributes adenosine monophosphate-activated protein kinase-dependent inhibition induced metformin. use offers mitigate common side effects. For example, lactic acidosis, known effect linked deficiency, oxidative nitrosative stress caused could be counterbalanced metformin’s enhancement glutathione. amplifies -induced activation kinase. conclusion, can benefit patients enhancing decreasing required dose maintaining optimal glycemia, lowering incidence metformin-associated acidosis.

Language: Английский

Citations

0