Potassium channels in depression: emerging roles and potential targets DOI Creative Commons
Jiahao Zhang, Zhu Yao, Meng Zhang

et al.

Cell & Bioscience, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 11, 2024

Potassium ion channels play a fundamental role in regulating cell membrane repolarization, modulating the frequency and shape of action potentials, maintaining resting potential. A growing number studies have indicated that dysfunction potassium associates with pathogenesis treatment depression. However, involvement onset depression has not been thoroughly summarized. In this review, we performed comprehensive analysis association between multiple their roles depression, compiles SNP loci associated as well antidepressant drugs target these channels. We discussed pivotal provide valuable insights into new therapeutic targets for critical clues to future drug discovery.

Language: Английский

A Novel Smart Hydrogel Strain Sensor for Efficient and Quantitative Detection of Blood Potassium Concentration with a Drop of Serum DOI Open Access
Jun Yao, Han Fu,

Y Xia

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Abstract Quantitative detection of potassium ion (K + ) concentration in serum is great significance for clinical diagnosis and management. Although various methods are developed quantitative K concentration, the existed techniques often fall short realization rapid with small volume sample. Here, a novel smart hydrogel strain sensor that combines poly( N ‐isopropylacrylamide‐ co ‐benzo‐15‐crown‐5‐acrylamide) (PNB) resistance gauge efficient by converting amplifying biochemical signals into easily measurable variations. By rationally regulating PNB hydrogels crosslinked Laponite XLG nanosheets, sensors can be rapidly achieved 2 min. Because sensitive transformation enables measurement extremely slight deformation hydrogels, only one drop 16 µL required to achieve blood sensors. The exhibit exceptional interference repeated performances. proposed strategy not offers method concentrations, but also opens up new window developing applications.

Language: Английский

Citations

0
Fentanyl and Sudden Death—A Postmortem Perspective for Diagnosing and Predicting Risk DOI Creative Commons
Ines Strenja-Linić, Elizabeta Dadić-Hero,

Manuela Perković

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(17), P. 1995 - 1995

Published: Sept. 9, 2024

Sudden, unexpected deaths are extremely difficult for families, especially when the victim is a child. Most sudden occur due to cardiovascular issues, and smaller number (approximately one-quarter) attributed other causes, such as epilepsy. The medicinal non-medicinal use of synthetic opioid fentanyl, which can cause breathing problems, frequently involved in these deaths. It also being found more often autopsies death cases, overdose from illicit drugs containing fentanyl increasing. There cases it mixed with drugs. A gene known KCNH2 or human ether-a-go-go-related (hERG), heart’s electrical activity, be related abnormal heart rhythms. This gene, along others, may play role use. In response, we have examined scientific literature on genetic variations that death, impact this process, potential benefits testing victims offer counseling their family members.

Language: Английский

Citations

1
Voltage Gated Ion Channels and Sleep DOI
Yan Zhang,

Jiawen Wu,

Yuxian Zheng

et al.

The Journal of Membrane Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Citations

1
Potassium channels in depression: emerging roles and potential targets DOI Creative Commons
Jiahao Zhang, Zhu Yao, Meng Zhang

et al.

Cell & Bioscience, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 11, 2024

Potassium ion channels play a fundamental role in regulating cell membrane repolarization, modulating the frequency and shape of action potentials, maintaining resting potential. A growing number studies have indicated that dysfunction potassium associates with pathogenesis treatment depression. However, involvement onset depression has not been thoroughly summarized. In this review, we performed comprehensive analysis association between multiple their roles depression, compiles SNP loci associated as well antidepressant drugs target these channels. We discussed pivotal provide valuable insights into new therapeutic targets for critical clues to future drug discovery.

Language: Английский

Citations

0