GSDMD-mediated mitochondrial dysfunction in marginal cells: A potential driver of inflammation and stria vascularis damage in CIHL
Yu Xiao,
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Xiaohan Zhang,
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Siwei Guo
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et al.
Proceedings of the National Academy of Sciences,
Journal Year:
2025,
Volume and Issue:
122(11)
Published: March 11, 2025
Inflammation
is
among
the
known
causes
of
cisplatin-induced
hearing
loss
(CIHL),
but
its
exact
pathophysiological
mechanisms
remain
unclear.
Herein,
we
demonstrated
that
pyroptosis—a
recently
identified
inflammatory
type
regulated
cell
death
dependent
on
gasdermin
D
(GSDMD)—was
activated
in
cochleae
cisplatin-treated
mice,
causing
CIHL.
Meanwhile,
treatment
with
GSDMD
inhibitor
necrosulfonamide
alleviated
CIHL
these
mice.
To
further
examine
role
GSDMD-mediated
pyroptosis
CIHL,
conducted
experiments
Gsdmd-
deficient
mice
.
Gsdmd
−/−
significantly
lower
cochlear
damage
than
control
and
appeared
to
be
invulnerable
Furthermore,
stria
vascularis
(SV),
not
hair
cells
(HCs),
played
a
dominant
In
marginal
(MCs)
SV,
cisplatin
induced
caspase-dependent
cleavage,
pore-forming
N-terminal
rapidly
localized
mitochondria,
leading
abnormal
mitochondrial
aggregation
oxidative
stress.
The
consequent
dysfunction
MCs
might
result
severe
progression
inflammation,
SV
damage,
HC
loss.
Notably,
pharmacological
inhibition
using
FDA-approved
drug
disulfiram
effectively
symptoms
Collectively,
findings
offer
broad
avenue
for
inhibiting
pyroptosis-induced
ototoxicity
provide
valuable
theoretical
insights
clinical
management
Language: Английский
Research Progress of Tinnitus and Neuroinflammation
Lixia Luo,
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Fengjing Nong,
No information about this author
Cheng Lu
No information about this author
et al.
Journal of Biosciences and Medicines,
Journal Year:
2025,
Volume and Issue:
13(04), P. 251 - 264
Published: Jan. 1, 2025
Language: Английский
A comprehensive review of the impact of natural products in preventing drug-induced ototoxicity
Inflammopharmacology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 8, 2025
Abstract
Ototoxicity,
the
property
of
certain
drugs
to
cause
hearing
loss,
is
a
significant
concern
in
medical
treatments,
particularly
with
use
chemotherapeutic
agents
like
cisplatin
and
aminoglycosides.
These
can
lead
permanent
sensorineural
loss
(SNHL),
affecting
substantial
proportion
patients.
Existing
strategies
alleviate
these
side
effects
are
limited,
prompting
interest
natural
products
as
potential
protective
agents.
Natural
being
investigated
for
their
ability
counteract
mechanisms
through
anti-inflammatory
antioxidant
properties.
The
review
seeks
highlight
complementary
therapies
conventional
ototoxic
medications,
emphasizing
roles,
which
involved
cochlear
cellular
damage
programmed
cell
death.
Further
research
essential
establish
standardized
protocols
ensure
integration
into
clinical
practice
effective
therapeutic
options.
Language: Английский