Published: Jan. 1, 2024
Language: Английский
Published: Jan. 1, 2024
Language: Английский
Experimental Neurology, Journal Year: 2025, Volume and Issue: 386, P. 115151 - 115151
Published: Jan. 19, 2025
Language: Английский
Citations
0Brain Research Bulletin, Journal Year: 2025, Volume and Issue: 222, P. 111245 - 111245
Published: Feb. 7, 2025
Mitochondrial dysfunction and neuronal impairment are hallmark features of Diabetes-Associated Cognitive Dysfunction (DACD), mitochondrial transplantation is also a therapeutic intervention for DACD. However, the precise mechanism underlying its effects not fully elucidated. Given that imbalances in copper homeostasis cuproptosis associated with various neurodegenerative disorders diabetic myocardial damage, we hypothesize role pathogenesis We further propose peripheral may ameliorate DACD by reducing processes cuproptosis. In this research, study delved into expression levels cuproptosis-associated proteins FDX1, LIAS, DLAT, as well content both type 2 diabetes mellitus (T2DM) mice primary cells exposed to high glucose palmitic acid (HG/Pal). Furthermore, cognitive capabilities were evaluated using series behavioral tests. The findings revealed neurons HG/Pal, was elevated, DLAT reduced. Post-transplantation platelet-derived mitochondria (Mito-Plt), significant reversal these biomarkers noted, coincident an improvement deficits T2DM mice. Significantly, agonist elesclomol (ES) aggravated alterations. summary, collectively suggest causal connection between development neurons. use exogenous Mito-Plt presents promising approach, capable rescuing from thereby potentially alleviating
Language: Английский
Citations
0Behavioural Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 115493 - 115493
Published: Feb. 1, 2025
Language: Английский
Citations
0Neuropsychopharmacology, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 7, 2024
Language: Английский
Citations
2Neurochemical Research, Journal Year: 2024, Volume and Issue: 50(1)
Published: Nov. 18, 2024
Language: Английский
Citations
0Published: Jan. 1, 2024
Language: Английский
Citations
0