A TrkB-mTOR Peptidomimetic Promotes Axon Regeneration and Restores Walking After Adult Spinal Cord Injury DOI

Chao‐wen Bai,

Chang She,

Huajian Shan

et al.

Published: Jan. 1, 2024

Language: Английский

Novel peptidomimetic compounds attenuate hypoxic-ischemic brain injury in neonatal rats DOI
Xiaodi Chen,

Brynn Kroke,

Jun Ni

et al.

Experimental Neurology, Journal Year: 2025, Volume and Issue: 386, P. 115151 - 115151

Published: Jan. 19, 2025

Language: Английский

Citations

0
Peripheral Mitochondrial Transplantation Alleviates Diabetes-Associated Cognitive Dysfunction by Suppressing Cuproptosis DOI Creative Commons

Juan Hu,

Qiao Li,

Shiqiu Jiang

et al.

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: 222, P. 111245 - 111245

Published: Feb. 7, 2025

Mitochondrial dysfunction and neuronal impairment are hallmark features of Diabetes-Associated Cognitive Dysfunction (DACD), mitochondrial transplantation is also a therapeutic intervention for DACD. However, the precise mechanism underlying its effects not fully elucidated. Given that imbalances in copper homeostasis cuproptosis associated with various neurodegenerative disorders diabetic myocardial damage, we hypothesize role pathogenesis We further propose peripheral may ameliorate DACD by reducing processes cuproptosis. In this research, study delved into expression levels cuproptosis-associated proteins FDX1, LIAS, DLAT, as well content both type 2 diabetes mellitus (T2DM) mice primary cells exposed to high glucose palmitic acid (HG/Pal). Furthermore, cognitive capabilities were evaluated using series behavioral tests. The findings revealed neurons HG/Pal, was elevated, DLAT reduced. Post-transplantation platelet-derived mitochondria (Mito-Plt), significant reversal these biomarkers noted, coincident an improvement deficits T2DM mice. Significantly, agonist elesclomol (ES) aggravated alterations. summary, collectively suggest causal connection between development neurons. use exogenous Mito-Plt presents promising approach, capable rescuing from thereby potentially alleviating

Language: Английский

Citations

0
Sigma-1 receptor agonist PRE-084 increases BDNF by activating the ERK/CREB pathway to rescue learning and memory impairment caused by type II diabetes DOI
Leilei Shi, Mingmei Wang,

Ruixuan Yu

et al.

Behavioural Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 115493 - 115493

Published: Feb. 1, 2025

Language: Английский

Citations

0
Target Identification of Ginsenosides Against Cognitive Impairment by Using Mass Spectrometry-Based Cellular Thermal Shift Assay (CETSA) DOI
Wei Qin, Feiyan Chen,

Qianlin Li

et al.

Neurochemical Research, Journal Year: 2025, Volume and Issue: 50(3)

Published: May 5, 2025

Language: Английский

Citations

0
Peptidomimetic inhibitors targeting TrkB/PSD-95 signaling improves cognition and seizure outcomes in an Angelman Syndrome mouse model DOI
Emily Z. Huie, Xin Yang,

Mengia S. Rioult-Pedotti

et al.

Neuropsychopharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 7, 2024

Language: Английский

Citations

2
AMP-Activated Protein Kinase Treatment Ameliorates Chronic Restraint Stress Induced Memory Impairment in Early Adolescent Rat by Restoring Metabolite Profile and Synaptic Proteins DOI
Koilmani Emmanuvel Rajan,

Baskaran Nishanthini,

Swamynathan Sowndharya

et al.

Neurochemical Research, Journal Year: 2024, Volume and Issue: 50(1)

Published: Nov. 18, 2024

Language: Английский

Citations

1
A TrkB-mTOR Peptidomimetic Promotes Axon Regeneration and Restores Walking After Adult Spinal Cord Injury DOI

Chao‐wen Bai,

Chang She,

Huajian Shan

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0