Pantothenic acid-mediated inhibition of microglial inflammation via the JAK2/STAT3 pathway enhances motor function recovery after Spinal cord injury
Abstract
This
study
employed
transcriptome
sequencing
and
targeted
metabolomics
to
delve
into
the
molecular
alterations
in
mouse
spinal
cords
following
cord
injury
(SCI).
Notably,
a
significant
depletion
of
pantothenic
acid
(PA)
was
observed
injured
cord,
exhibiting
an
inverse
correlation
with
microglial
inflammation
activation.
To
further
elucidate
this
relationship,
experimental
interventions
using
PA
were
conducted
SCI
models.
The
results
demonstrated
that
administration
effectively
inhibited
via
modulation
JAK2/STAT3
signaling
pathway.
inhibition
not
only
mitigated
neuroinflammatory
milieu
but
also
fostered
environment
conducive
axonal
growth
neuronal
regeneration.
Consequently,
mice
treated
exhibited
improved
motor
function
recovery
compared
untreated
controls.
Our
findings
deepen
understanding
relationship
between
processes
highlight
therapeutic
potential
promoting
regeneration
functional
recovery.
Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 19, 2024
Language: Английский