Targeting Ferroptosis in Parkinson’s Disease: Mechanisms and Emerging Therapeutic Strategies

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 13042 - 13042

Published: Dec. 4, 2024

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the loss of dopaminergic neurons in substantia nigra and accumulation α-synuclein brain. Ferroptosis, recently identified form regulated cell death, critical PD pathogenesis due to its association with iron deposition, overproduction reactive oxygen species, iron-dependent lipid peroxidation impaired clearance. This death mechanism closely linked several pathogenic processes PD, including aggregation, oxidative stress, mitochondrial dysfunction, microglia-induced neuroinflammation, neuromelanin accumulation. Given significant role ferroptosis these mechanisms, there increasing interest targeting for treatment. Several drugs have shown potential alleviating symptoms inhibiting ferroptosis. review aims consolidate current knowledge on assess therapeutic anti-ferroptosis drugs, highlighting promising directions future research clinical applications.

Language: Английский

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Extracellular vesicles as drug and gene delivery vehicles in central nervous system diseases

Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This review summarizes naïve extracellular vesicles (EVs) in clinical trials for central nervous system (CNS) diseases and updates recent translational preclinical research on EV-loaded drugs or genes CNS treatments.

Language: Английский

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Clinical state and future directions of stem cell therapy in stroke rehabilitation

Experimental Neurology, Journal Year: 2024, Volume and Issue: 385, P. 115132 - 115132

Published: Dec. 30, 2024

Language: Английский

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