Polyphenols, Alkaloids, and Terpenoids Against Neurodegeneration: Evaluating the Neuroprotective Effects of Phytocompounds Through a Comprehensive Review of the Current Evidence
Enzo Pereira de Lima,
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Lucas Fornari Laurindo,
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Vitor Cavallari Strozze Catharin
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et al.
Metabolites,
Journal Year:
2025,
Volume and Issue:
15(2), P. 124 - 124
Published: Feb. 13, 2025
Neurodegenerative
diseases
comprise
a
group
of
chronic,
usually
age-related,
disorders
characterized
by
progressive
neuronal
loss,
deformation
structure,
or
loss
function,
leading
to
substantially
reduced
quality
life.
They
remain
significant
focus
scientific
and
clinical
interest
due
their
increasing
medical
social
importance.
Most
neurodegenerative
present
intracellular
protein
aggregation
extracellular
deposition
(plaques),
such
as
α-synuclein
in
Parkinson's
disease
amyloid
beta
(Aβ)/tau
aggregates
Alzheimer's.
Conventional
treatments
for
conditions
incur
high
costs
are
related
the
development
several
adverse
effects.
In
addition,
many
patients
irresponsive
them.
For
these
reasons,
there
is
growing
tendency
find
new
therapeutic
approaches
help
patients.
This
review
intends
investigate
some
phytocompounds'
effects
on
diseases.
These
generally
increased
oxidative
stress
inflammation,
so
phytocompounds
can
prevent
treat
To
achieve
our
aim
provide
critical
assessment
current
literature
about
phytochemicals
targeting
neurodegeneration,
we
reviewed
reputable
databases,
including
PubMed,
EMBASE,
COCHRANE,
seeking
trials
that
utilized
against
conditions.
A
few
investigated
humans,
after
screening,
13
were
ultimately
included
following
PRISMA
guidelines.
compounds
include
polyphenols
(flavonoids
luteolin
quercetin,
phenolic
acids
rosmarinic
acid,
ferulic
caffeic
other
like
resveratrol),
alkaloids
(such
berberine,
huperzine
A,
caffeine),
terpenoids
ginkgolides
limonene).
The
gathered
evidence
underscores
caffeine,
ginkgolides,
primarily
anti-inflammatory,
antioxidant,
neuroprotective,
counteracting
neuroinflammation,
oxidation,
synaptic
dysfunctions,
which
crucial
aspects
intervention
various
conditions,
Alzheimer's
dementias,
depression,
neuropsychiatric
disorders.
summary,
they
show
use
improvements
cognition,
memory,
disinhibition,
irritability/lability,
aberrant
behavior,
hallucinations,
mood
Language: Английский
Advances in the Study of Necroptosis in Vascular Dementia: Focus on Blood–Brain Barrier and Neuroinflammation
Yuemin Qiu,
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Lin Cheng,
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Yinyi Xiong
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et al.
CNS Neuroscience & Therapeutics,
Journal Year:
2025,
Volume and Issue:
31(2)
Published: Feb. 1, 2025
ABSTRACT
Background
Vascular
dementia
(VaD)
includes
a
group
of
brain
disorders
that
are
characterized
by
cerebrovascular
pathology.Neuroinflammation,
disruption
the
blood–brain
barrier
(BBB)
permeability,
white
matter
lesions,
and
neuronal
loss
all
significant
pathological
manifestations
VaD
play
key
role
in
disease
progression.
Necroptosis,
also
known
asprogrammed
necrosis,
is
mode
programmed
cell
death
distinct
from
apoptosis
closely
associated
with
ischemic
injury
neurodegenerative
diseases.
Recent
studies
have
shown
necroptosis
exacerbates
BBB
destruction,
activates
neuroinflammation,
promotes
loss,
severely
affects
prognosis.
Results
Conclusions
In
this
review,
we
outline
roles
its
molecular
mechanisms
process
VaD,
particular
focus
on
modulating
neuroinflammation
exacerbating
permeability
elaborate
regulatory
centrally
involved
cells
mediated
tumor
necrosis
factor‐α
VaD.
We
analyze
possibility
specific
strategy
targeting
would
help
inhibit
destruction
With
necroptosis,
study
delved
into
impact
changes
prognosis
to
provide
new
treatment
ideas.
Language: Английский
Neuroinflammatory response after subarachnoid hemorrhage: A review of possible treatment targets
Xiuwen Fu,
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Chenlu Li,
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Hongru Jiang
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et al.
Clinical Neurology and Neurosurgery,
Journal Year:
2025,
Volume and Issue:
unknown, P. 108843 - 108843
Published: March 1, 2025
A
serious
neurosurgical
emergency,
subarachnoid
hemorrhage
(SAH)
is
characterized
by
vascular
and
neuropathy,
as
well
complex
pathological
mechanisms
like
lesions,
inflammatory
responses,
nerve
cell
damage.
The
response
an
essential
aspect
of
SAH's
pathophysiology,
causing
the
release
a
number
mediators
oxidative
stress
products
TNF-α,
MCP-1,
MMPs,
so
on,
which
either
directly
or
indirectly
contribute
to
development
SAH.It
has
recently
been
discovered
that
some
antibodies
against
mediators,
antioxidant
stress,
botanicals,
traditional
Chinese
medicine
decrease
SAH.
Additionally,
certain
biomarkers
linked
inflammation
may
serve
foundation
for
clinical
diagnosis.Although
these
are
still
not
completely
understood,
we
can
explore
potential
therapeutic
targets
studying
role
responses
bioactive
molecules
in
formation
Language: Английский
The current approaches to modeling the brain ischemia–reperfusion and inflammation: from animal models toward vascularized and neuroimmune cerebral organoids
Pavel P. Tregub,
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Daria D. Volegova,
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Arseniy K. Berdnikov
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et al.
Reviews in the Neurosciences,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 27, 2025
Abstract
For
several
decades,
the
modeling
of
brain
diseases
in
experimental
animals
has
remained
one
key
components
studying
pathogenesis
central
nervous
system
pathology
and
searching
for
new
methods
prevention
therapy.
In
recent
years,
approaches
to
pathological
conditions
vitro
have
been
active
development;
these
will
not
only
reduce
number
animal
studies
but
also
allow
us
take
a
step
toward
reproducing
human-specific
mechanisms
pathology.
this
review,
we
characterize
most
common
rodent
models
cerebral
ischemia
reperfusion,
as
well
neuroinflammation
inherent
neurodegeneration
(in
particular,
Parkinson’s
disease),
which
are
reproduced
vivo
.
This
review
addresses
engineering
technical
challenges
prospects
development
,
e.g.,
vascularized
microglia-containing/neuroimmune
organoids,
may
be
useful
overcoming
shortcomings
limitations
current
models.
Language: Английский