Lateral Ventricular Neural Stem Cells Provide Negative Feedback to Circuit Activation Through GABAergic Signaling
Cells,
Journal Year:
2025,
Volume and Issue:
14(6), P. 426 - 426
Published: March 13, 2025
Recent
studies
have
demonstrated
that
circuit
activation
in
vivo
can
regulate
proliferation
of
lateral
ventricular
neural
stem
cells
(LV
NSCs),
although
the
underlying
molecular
and
cellular
mechanisms
are
not
yet
fully
understood.
Here,
we
investigated
role
GABAergic
signaling
interaction
between
LV
NSCs
anterior
cingulate
cortex-subependymal-choline
acetyltransferase+
(ChAT+)
neuron
(ACC-subep-ChAT+)
circuit.
We
found
monoamine
oxidase
B
(MAOB),
a
key
enzyme
involved
gamma-aminobutyric
acid
(GABA)
synthesis,
is
expressed
NSCs,
ACC-subep-ChAT+
modulate
MAOB
activity.
Additionally,
express
LRRC8D,
core
component
volume-regulated
anion
channels,
GABA
transporter-1
(GAT-1,
SLC6A1).
show
evidence
that,
through
signaling,
LRRC8D
GAT-1
provide
negative
feedback
signal
to
ChAT+
neurons,
NSCs.
These
findings
suggest
MAOB-driven
LRRC8D-regulated
chloride
transport,
GAT-1-facilitated
reuptake
influence
NSC
dynamics
LV.
Language: Английский
Olfactory bulb interneurons – The developmental timeline and targeting defined by embryonic neurogenesis
Molecular and Cellular Neuroscience,
Journal Year:
2025,
Volume and Issue:
unknown, P. 104007 - 104007
Published: March 1, 2025
Language: Английский
Decoding the Secrets of Odor‐Active Compounds in Dark Tea
Lianqing Wang,
No information about this author
Jianan Huang,
No information about this author
Zhonghua Liu
No information about this author
et al.
Comprehensive Reviews in Food Science and Food Safety,
Journal Year:
2025,
Volume and Issue:
24(3)
Published: May 1, 2025
ABSTRACT
Dark
tea
has
received
growing
attention
in
recent
years
due
to
its
distinctive
aroma
and
potential
health
benefits.
The
overall
profile
of
dark
is
determined
by
the
combined
effects
diverse
odor‐active
compounds
(OACs).
However,
comprehensive
studies
on
these
remain
limited.
Beyond
role
sensory
perception,
could
also
exert
physiological
functions?
Existing
research
primarily
focused
benefits
non‐volatile
components
tea,
such
as
polyphenols,
polysaccharides,
theanine.
OACs
influence
processes
via
olfactory
receptors
(ORs)
remains
underexplored
literature.
Accordingly,
we
systematically
classify
comprehensively
review
OACs.
Furthermore,
examine
OAC–OR
interactions,
encompassing
not
only
their
roles
recognition
emotion
regulation
nasal
ORs
but
therapeutic
applications
mediated
non‐nasal
ORs.
Interestingly,
our
findings
reveal
that
follow
a
“structure‐similarity–function‐convergence”
trend
both
bioactivity
aromatic
properties.
Specifically,
structurally
similar
impart
analogous
profiles
may
share
comparable
functions.
This
phenomenon
provides
new
insights
into
flavor
compounds.
enhances
understanding
systematically,
for
first
time,
explores
health‐related
functions
interactions
between
It
offers
future
integrative
food
shed
light
synergistic
odor
bioactive
regulation.
Language: Английский
Embryonically generated interneurons (EGINs) exhibit a distinctive developmental program and lamination in the olfactory bulb
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 25, 2024
Interneurons
(INs)
in
the
mouse
olfactory
bulb
(OB)
develop
during
an
extensive
period
of
time
that
begins
embryo
and
continues
throughout
lifetime
individual.
The
connectivity
location
these
neurons
is
profoundly
affected
by
generation,
making
developmental
windows
critical
to
understand
circuitry
OB.
Here,
we
focus
on
OB
embryonic
generated
interneurons
(or
EGINs),
which
have
generally
received
less
attention
than
those
adult.
Birthdates
EGINs
were
differentiated
injections
thymidine
analogs
their
final
destinations
phenotypes
analyzed
immunohistochemistry.
We
found
retained
adult
distributed
across
all
layers
However,
a
lateral-to-medial
neurogenic
gradient
seen
only
earliest
EGINs.
Within
granule
cell
layer
(GCL),
predominantly
accumulated
superficial
region
at
almost
ages
remained
there
adulthood.
Immunostaining
for
calbindin,
parvalbumin,
tyrosine
hydroxylase,
calretinin
largely
negative
suggesting
may
represent
subpopulations
INs
are
not
yet
fully
characterized.
Using
utero
electroporation
label
EGIN
progenitors,
demonstrated
they
reach
primordial
as
early
E13
begin
differentiate
apical
dendrites
E15.
At
E16,
progenitors
clustered
into
chain
migrating
neuroblasts
denoting
rostral
migratory
stream
(RMS).
Collectively,
our
data
highlight
importance
studying
isolated
better
formation
circuits
define
responses.
Language: Английский