Appraising the Effects of Gut Microbiota on Insomnia Risk Through Genetic Causal Analysis

American Journal of Medical Genetics Part B Neuropsychiatric Genetics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

ABSTRACT BackgroundInsomnia is a common neurological disorder that exhibits connections with the gut microbiota; however, exact causal relationship remains unclear. MethodsWe conducted Mendelian randomization (MR) study to systematically evaluate effects of genus‐level microbiota on insomnia risk in individuals European ancestry. Summary‐level datasets were sourced from genome‐wide association (GWAS) MiBioGen, while obtained GWAS Neale Lab and FinnGen. The primary analytical approach used was inverse‐variance weighted (IVW) method, supplemented by MR‐Egger, maximum likelihood, MR‐robust adjusted profile score, median. Sensitivity analyses ensure robustness. ResultsThe microbial taxa Enterorhabdus , Family XIII AD3011 group Paraprevotella Lachnospiraceae UCG004 associated an increased insomnia, whereas Coprococcus1 Coprobacter, Desulfovibrio, Flavonifractor, Olsenella, Odoribacter Oscillibacter linked decreased risk. Regarding phenotype characterized trouble falling asleep, taxon Eisenbergiella correlated risk, Haemophilus Eubacterium brachy reduced Furthermore, for waking too early, UCG001 FCS020 Olsenella Victivallis lower results remained robust across all sensitivity analyses. ConclusionOur MR identified multiple may exhibit potential genetic perspective. These findings provide evidence supporting theory microbiota‐gut‐brain axis offer new insights into prevention therapeutic targets insomnia.

Language: Английский

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Sleep‐enhancing activity of fermented pea protein hydrolysate with enhanced GABA content by Lactobacillus brevisSYLB 0016 fermentation

Journal of the Science of Food and Agriculture, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Abstract BACKGROUND Sleep is essential for overall health and wellbeing. This study investigated the sleep‐promoting effects of fermented pea protein hydrolysate (PPF) with increased gamma‐aminobutyric acid (GABA) content produced by Lactobacillus brevis SYLB 0016. The PPF on sleep duration structure were assessed in pentobarbital‐induced ICR mice Sprague Dawley (SD) rats using electroencephalogram (EEG) analysis. RESULTS Hydrolysis Alcalase, Protana Prime, UBoost amino nitrogen content, degree hydrolysis glutamate to 160.51 mmol L −1 . Fermentation 0016 GABA from 3.16 90.35 significantly (56.3 min) compared normal control (30.6 tests. Non‐rapid eye movement (NREM) time a significant rise δ‐waves activity following administration 150 mg kg PPF. In caffeine‐induced insomnia, both low‐ high‐dose duration. Three weeks oral elevated A B receptor expression, levels showing change. Co‐administration flumazenil reduced time, indicating involvement benzodiazepine site PPF's sleep‐enhancing effects. CONCLUSION conclusion, enhanced improves NREM increasing δ waves activity. As hypoallergenic compound, holds potential as supplement ameliorate disorders. © 2025 Society Chemical Industry.

Language: Английский

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Beneficial Effects of Dendrobium officinale Extract on Insomnia Rats Induced by Strong Light and Noise via Regulating GABA and GABAA Receptors

Chinese Journal of Integrative Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Language: Английский

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Modulatory Sedative Activity of Abrine on Diazepam in Thiopental Sodium Mediated Sleeping Mice: An In Vivo Approach with Receptor Binding Affinity of GABAergic Transmission

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(37)

Published: Sept. 30, 2024

Abstract The current study aims to assess the effects of abrine (ABR) in thiopental sodium (TS)‐induced sleeping mice and explore sedative impacts compound by using vivo silico investigations. ABR (5 10 mg k −1 g, i.p.) diazepam (DZP) (2 were administered experimental animals either single or combined. TS (20 was induce sleep, latency with duration observed for 3 h. investigation conducted predict role gamma‐aminobutyric acid A (GABA ) receptor process evaluate pharmacokinetics toxicity. Results showed that (10 g) significantly ( p < 0.05) decreased period (8.20 ± 1.85 min) enhanced sleep (187.8 8.87 comparison control group. Additionally, co‐treatments DZP remarkably reduced (4.40 0.24 increased (201.40 5.89 compared therapy. molecular docking indicated has a binding affinity −7.4 kcal/mol GABA receptor. In conclusion, provides strong synergistic efficacy on TS‐induced via GABAergic system.

Language: Английский

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THE IMPORTANCE OF ACTIVATING AND INHIBITORY SYSTEMS OF THE BRAIN IN THE REGULATION OF THE SLEEP-WAKE CYCLE

Bulletin of Problems Biology and Medicine, Journal Year: 2024, Volume and Issue: 1(2), P. 63 - 63

Published: Jan. 1, 2024

Language: Английский

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Research progress on the effect of medicine and food homology resources for sleep improvement

Heliyon, Journal Year: 2024, Volume and Issue: 10(21), P. e40067 - e40067

Published: Nov. 1, 2024

Insomnia can have a negative impact on people's life or even cause mental physical diseases. In China, the usage of medicine food homology herbal resources to treat insomnia has long history. This review, which is based theory traditional Chinese (TCM), summarizes research progress and (MFH) in treating insomnia. Through literature search from last 8 years, we compared understanding between TCM modern pharmacology, found 21 kinds MFH plants 15 prescriptions containing that effect improving sleep summarized mechanism their treatment Our study will provide theoretical support for development utilization plant with sleep-enhancing properties positive insights direction references more effective disease.

Language: Английский

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Pharmacotherapy only? Overview of available treatments for sleep disorders

Problemy Pielęgniarstwa, Journal Year: 2024, Volume and Issue: 32(1), P. 7 - 14

Published: Jan. 1, 2024

AMA Górska K, Antoniak-Sobczak Ścisło L, et al. Pharmacotherapy only? Overview of available treatments for sleep disorders. Nursing Problems / Problemy Pielęgniarstwa. 2024;32(1):7-14. doi:10.5114/ppiel.2024.139127. APA Górska, K., Antoniak-Sobczak, Ścisło, L., Pluta, J., M., & Buczkowska, M. (2024). Pielęgniarstwa, 32(1), 7-14. https://doi.org/10.5114/ppiel.2024.139127 Chicago Karolina, Katarzyna Lucyna Judyta Mateusz Marta and Michał K. Górski. 2024. "Pharmacotherapy disorders". Pielęgniarstwa 32 (1): Harvard Górski, pp.7-14. MLA Karolina disorders." vol. 32, no. 1, 2024, pp. Vancouver Pluta J, M, Buczkowska M

Language: Английский

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Comparison of resting-state brain activity between insomnia and generalized anxiety disorder: A coordinate-based meta-analysis

Brain Imaging and Behavior, Journal Year: 2024, Volume and Issue: 19(1), P. 218 - 239

Published: Oct. 10, 2024

Language: Английский

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Targeting retrieval of methamphetamine reward memory in the context of REM sleep deprivation: Age-dependent role of GABAB receptors

Pharmacology Biochemistry and Behavior, Journal Year: 2024, Volume and Issue: unknown, P. 173900 - 173900

Published: Oct. 1, 2024

Language: Английский

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Therapeutic Effect of Yu Melody Relaxation Training Combined with Jianpi Jieyu Decoction in Insomnia Patients: A Randomized Controlled Trial

Chinese Journal of Integrative Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

Language: Английский

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